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Cited by 20Memory and Neural MechanismsNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

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Effects of pre-training morphine on spatial memory acquisition and retrieval in mice

Zhu, Feng, Yan, Chun-xia, Zhao, Yan, Zhao, Yang, Li, Ping-ping, Li, Sheng-bin·2011·Physiology & Behavior
DOI 10.1016/j.physbeh.2011.07.014
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Abstract

The opioid system plays an important role in memory processess. Morphine mimics endogenous opioids by acting on opioid receptor in brain to regulate memory. However, the effects of morphine on spatial memory acquisition are controversial. Also, little evidence has suggested that morphine could affect the retrieval of spatial memory. In the current study, effects of pre-training morphine and naloxone on the acquisition vs. retrieval of spatial reference vs. working memory were examined using discrete water maze tasks in C57BL/6 mice. Pre-training morphine administration (7.5 and 15 mg/kg, i.p.) impaired the acquisition of both spatial reference memory and working memory. Motivation to escape from the water maze was not affected by morphine. Pre-test morphine also inhibited the retrieval of spatial working memory but not reference memory. The effects of morphine on the acquisition and retrieval of spatial working memory were eliminated by naloxone pretreatment (1mg/kg). These results indicate that morphine could differentially modulate a variety of aspects of spatial memory and these effects are mediated by the mu-opioid receptor.

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Metadata

Authors
Zhu, F., Yan, C.-X., Zhao, Y., Zhao, Y., Li, P.-P., & Li, S.-B.
Affiliations
Xi'an Jiaotong University (CN)
Corresponding author
Li, Sheng-bin
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2011-10
Volume
104
Issue
5
Pages
754-760
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2011.07.014
OpenAlex
W2040932427
Cited by
20
References
1
Citations by year
2026: 1 · 2024: 1 · 2021: 1 · 2019: 4 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
0.97
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Foundation of Shaanxi HR Department for Well-trained Personnel from Abroad (SLZ2008010)
  • Foundation of Xi'an Jiaotong University for New Frontier and Interdisciplinary Study (201075)
  • Guanghua Medical Innovative Research (0203417)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
morphine, spatial memory, memory acquisition, memory retrieval, spatial working memory, spatial reference memory, mu-opioid receptor, naloxone, opioid system, water maze, escape motivation, mice
MeSH terms
Analysis of Variance, Animals, Behavior, Animal, Conditioning, Operant, Cues, Dose-Response Relationship, Drug, Drug Administration Schedule, Exploratory Behavior, Male, Mice, Inbred C57BL, Morphine, Motivation, Naloxone, Narcotic Antagonists, Narcotics, Reaction Time, Mental Recall, Space Perception, Time Factors, Maze Learning, Mice

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CoChat. (2026). Citation check: Effects of pre-training morphine on spatial memory acquisition and retrieval in mice. https://app.cochat.ai/papers/10.1016/j.physbeh.2011.07.014
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Zhu, F., Yan, C.-X., Zhao, Y., Zhao, Y., Li, P.-P., & Li, S.-B. (2011). Effects of pre-training morphine on spatial memory acquisition and retrieval in mice. Physiology & Behavior. https://doi.org/10.1016/j.physbeh.2011.07.014