Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice.

Oliveira-Lima, A.J.; Santos, R.; Hollais, A.W.; Gerardi-Junior, C.A.; Baldaia, M.A.; Wuo-Silva, R.; Yokoyama, T.S.; Costa, J.L.; Malpezzi-Marinho, E.L.A.; Ribeiro-Barbosa, P.C.; Berro, L.F.; Frussa-Filho, R.; Marinho, E.A.V.

doi:10.1016/j.physbeh.2015.01.032

Cited by 91Neurotransmitter Receptor Influence on BehaviorPsychedelics and Drug StudiesSubstance Abuse Treatment and Outcomes

Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice.

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Oliveira-Lima, A.J., Santos, R., Hollais, A.W., Gerardi-Junior, C.A., Baldaia, M.A., Wuo-Silva, R., Yokoyama, T.S., Costa, J.L. +5 more·2015·Physiology & Behavior

DOI 10.1016/j.physbeh.2015.01.032

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Abstract

Background Hallucinogenic drugs were used to treat alcoholic patients in the past, and recent developments in the study of hallucinogens led to a renewal of interest regarding the application of these drugs in the treatment of addiction. In this scenario, accumulating evidence suggests that the hallucinogenic brew ayahuasca (Aya) may have therapeutic effects on substance abuse problems.Methods We investigated the effects of Aya on spontaneous locomotor activity and ethanol(Eth)-induced hyperlocomotion and subsequent locomotor sensitization by a two-injection protocol. Additionally, we tested the effect of Aya on an 8-day counter-sensitization protocol to modify sensitized responses induced by a repeated treatment with Eth (1.8g/kg) for 8 alternate days.Results Aya showed high sensitivity in preventing the development of Eth-induced behavioral sensitization, attenuating it at all doses (30, 100, 200, 300 or 500 mg/kg) without modifying spontaneous locomotor activity. At the highest doses (300 and 500 mg/kg), Aya also showed selectivity to both acute and sensitized Eth responses. Finally, a counter-sensitization strategy with 100 or 300 mg/kg of Aya for 8 consecutive days after the establishment of Eth-induced behavioral sensitization was effective in blocking its subsequent expression on an Eth challenge.Conclusions We demonstrated that Aya not only inhibits early behaviors associated with the initiation and development of Eth addiction, but also showed effectiveness in reversing long-term drug effects expression, inhibiting the reinstatement of Eth-induced behavioral sensitization when administered in the Eth-associated environment.

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Animal experiments (Oliveira-Lima et al., 2015) demonstrated that ayahuasca not only inhibits early behaviors associated with initiation and development of alcohol addiction but also has long-term effects preventing reinstatement of ethanol-induced behavioral sensitization.
“This model is supported by animal experiments (Oliveira-Lima et al., 2015) which demonstrated that ayahuasca not only inhibits early behaviors associated with the initiation and development of alcohol addiction, but also has long-term effects in preventing the reinstatement of ethanol-induced behavioral sensitization.”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as Oliveira-Lima et al., 2015

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Toxicological Aspects and Determination of the Main Components of Ayahuasca: A Critical Review
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A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder
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Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice
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Effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on ethanol consumption and place conditioning in male mice
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Within-treatment changes in a novel addiction treatment program using traditional Amazonian medicine
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Ayahuasca and tobacco smoking cessation: results from an online survey in Brazil
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The renaissance in psychedelic research: What do preclinical models have to offer
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Components of Banisteriopsis caapi, a Plant Used in the Preparation of the Psychoactive Ayahuasca, Induce Anti-Inflammatory Effects in Microglial Cells
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Dimethyltryptamine: Endogenous Role and Therapeutic Potential
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Ayahuasca Beverages: Phytochemical Analysis and Biological Properties
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Protocol for Outcome Evaluation of Ayahuasca-Assisted Addiction Treatment: The Case of Takiwasi Center
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Effects of the hallucinogenic beverage ayahuasca on voluntary ethanol intake by rats and on cFos expression in brain areas relevant to drug addiction
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Role of 5-HT2A receptors in the effects of ayahuasca on ethanol self-administration using a two-bottle choice paradigm in male mice
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Treating Addiction
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Ayahuasca blocks ethanol preference in an animal model of dependence and shows no acute toxicity
Gianfratti, B., Tabach, R., Sakalem, M. E., Stessuk, T., Maia, L. O., & Carlini, E. A. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114865 · Cited by 25 · see citing works
Correction to: Toxicity of ayahuasca after 28 days daily exposure and effects on monoamines and brain-derived neurotrophic factor (BDNF) in brain of Wistar rats
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Ayahuasca blocks the reinstatement of methylphenidate-induced conditioned place preference in mice: behavioral and brain Fos expression evaluations
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The current state of ayahuasca research in animal models: A systematic review
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A Systematic Review on the Therapeutic Effects of Ayahuasca
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Three Naturally-Occurring Psychedelics and Their Significance in the Treatment of Mental Health Disorders
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The Therapeutic Potential of Psychedelics in Treating Substance Use Disorders: A Review of Clinical Trials
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It’s Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish
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Psychosocial and Drug Use Assessment of Regular vs. Non-Regular Ayahuasca Users in a Brazilian Sample: a Web-Based Survey
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Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice
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Molecular and structural insights into the 5‐HT 2C receptor as a therapeutic target for substance use disorders
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Classic psychedelics and the treatment for alcoholism
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Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice
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Context-dependent effects of rimonabant on ethanol-induced conditioned place preference in female mice
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Effects of repeated ayahuasca administration on behaviour and c-Fos expression in male rats exposed to the open field
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Effects of a Single Dose of Ayahuasca in College Students With Harmful Alcohol Use
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Plants with Anti-Addictive Potential
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Therapeutic Use of Hallucinogens
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Ayahuasca for the treatment of alcohol use disorder
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Behavioral cross-sensitization between cocaine and ethanol is accompanied by parallel changes in the activity of AMPK system
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Use of Herbal Medicine to Treat Drug Addiction
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Distinctive Neuroanatomic Regions Involved in Cocaine-Induced Behavioral Sensitization in Mice
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The Therapeutic Effects of Classic Psychedelics in Alcohol Use Disorder
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Aripiprazole and topiramate, alone or in combination, block the expression of ethanol-induced conditioned place preference in mice
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Context-dependent effects of the CB1 receptor antagonist rimonabant on morphine-induced behavioral sensitization in female mice
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Established sensitization of ethanol-induced locomotor activity is not reversed by psilocybin or the 5-HT2A receptor agonist TCB-2 in male DBA/2J mice
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A quantitative textual analysis of the subjective effects of ayahuasca in naïve users with and without depression
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Behavioral characterization of ayahuasca treatment on Wistar rats in the open field test
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Ayahuasca drinking using a two-bottle choice procedure in male mice
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Treatment with zolpidem after ethanol administration potentiates the expression of ethanol-induced behavioral sensitization in mice
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The L‐arginine‐NO‐cGMP pathway mediates the locomotor activity alterations during the expression of sensitization to mephedrone in mice
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Ayahuasca no tratamento da farmacodependência à cocaína: possíveis intervenções terapêuticas?
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Ayahuasca, qualidade de vida e a esperança de adictos em recuperação: relatos de caso
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Ayahuasca as a Versatile Therapeutic Agent: From Molecules to Metacognition and Back
Valle, M., Domínguez‐Clavé, E., Elices, M., Pascual, J. C., Soler, J., Morales-Garcia, J. A., Pérez‐Castillo, A., & Jordi Riba, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-55688-4_1
ルポ昼休みを生かしてリフレッシュ--東京急行電鉄(株)車両部長津田検車区 (作業の合間でリフレッシュ--休憩時間の過ごし方のヒント )
労働衛生編集部 (1995) · 労働衛生
Erratum
(2022) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902022e19373e
Desenvolvimento de métodos analíticos para determinação dos alcaloides da ayahuasca em diferentes matrizes aplicando estratégias de química analítica verde
Silveira, G. D. O. (2020) · doi:10.11606/t.9.2020.tde-25082022-101857
Modulação da atividade encefálica pelo canabidiol em camundongos tratados com cocaína
Spelta, L. E. W. (2022) · doi:10.11606/t.9.2022.tde-01122022-181624
Desenvolvimento de método baseado em Toxicologia Analítica Verde para determinação dos componentes ativos da ayahuasca em cabelo
Santos, F. P. (2023) · doi:10.11606/d.9.2023.tde-12122023-105953
Psychedelics in psychiatry
SANTOS, R. G. D., & Hallak, J. E. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18496-3.00015-x
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Effects of Ayahuasca on Ethanol-Conditioned Place Preference and ΔFosB Expression in the Nucleus Accumbens in MicePreprint
Wiltenburg, V. D., Morales-Lima, G., Santos, A. V. S., Echeverry, M. B., Cruz, F. C., Silveira, G. D. O., Yonamine, M., Tiba, P. A., & Mendes, F. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.07.592962
Evaluating the Effectiveness of Psychedelic-Assisted Therapy in Treating Alcohol Use Disorders: A Review
Shah, R. J., & Sarangi, A. (2025) · Alcoholism Treatment Quarterly · doi:10.1080/07347324.2025.2500345
Effects of ayahuasca in preclinical studies with animals: a systematic review
Walsh-Monteiro, A., Morato, S., Uribe, F. A. R., Gouvêia, A., & Pedroso, J. D. S. (2025) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2025e14687
Psychedelics for the Treatment of Substance Use Disorder
Fumàs, B., Pubill, D., López‐Arnau, R., & Nadal‐Gratacós, N. (2025) · Pharmaceutical science. · doi:10.5772/intechopen.1012870
Ayahuasca prevents the reinstatement of cocaine-induced rewarding effects in C57Bl/6 mice
Bruno, V., Spelta, L. E. W., Pereira, M. L., Dörr, F., Paranhos, B. A. P. B., Santos, F. P., Yonamine, M., Garcia, R. C. T., Torres, L. H., Pasquale, R. D., et al. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06946-0
Dimethyltryptamine and harmine, components of ayahuasca, prevented cocaine-induced apoptosis in SH-SY5Y human neuroblastoma cells
Salles, G., Almeida, C. A. D. F., Alves, I. D. C., Braz, G. D. A., Lopes, F. B., Fernandes, J. P. S., Chagas‐Paula, D. A., Neto, A. K., Alves, M. F., Bruno, V., et al. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04208-8
Single Ayahuasca administration attenuates alcohol relapse and associated behavioral, neurochemical, and oxidative alterations in rats
Lodetti, G., de Bitencourt, R. M., Inserra, A., Redivo, H., Teixeira, A. G., de Farias, A. C. S., Pickler, K. D. P., Rohling, J. P. V., Endler, A. T., Zampronio, E. P., et al. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111817
POTENCIAL TERAPÊUTICO DA AYAHUASCA NO MANEJO DO ALCOOLISMO: UMA REVISÃO INTEGRATIVA
Neto, A. V. J., de Sousa, A. K., Rocha, C. C. V., Tavares, D. S. A., Júnior, D. L. D. S., de Carvalho, F. A. R., da Costa, H. R. A., Macedos, I., Silva, J. C., SILVA, M. E. F. S., et al. (2026) · Editora Omnis Scietia eBooks · doi:10.47094/978-65-284-0602-9/143-159
Ayahuasca treatment reduces 50-kHz ultrasonic vocalizations and modifies mesocorticolimbic monoamine neurochemistry in rats
de Souza, C. P., Theiss-De-Rosso, V., Daneluz, D. M., Sohn, J. M. B., de Almeida, J. G. S., Guaita, G. D. O., Vieira, G. H., da Silveira, G. O. A., Yonamine, M., Schwarting, R. K. W., et al. (2026) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2026.174274
Acute ayahuasca administration attenuates binge‐like eating and anxiety‐related behaviors in mice subjected to intermittent fasting
Corona, C. F., Lima, F. A. A., Sumensse, J. S. C. D. S., Carvalho, K. D., Grignet, P. H., Confortim, H. D., Gross, M. C., Firmino, F. A., Evangelista, F. F., do Nascimento, F. P., et al. (2026) · Journal of Neuroendocrinology · doi:10.1111/jne.70290

Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice
Almeida, C. A. D. F., Pereira-Júnior, A. A., Rangel, J. G., Pereira, B. P., Costa, K. C. M., Bruno, V., Silveira, G. D. O., Ceron, C. S., Yonamine, M., Camarini, R., et al. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113546 · Cited by 35 · see citing works
Acamprosate and relapse prevention: Results from a pooled analysis of 11 randomised placebo-controlled trials in 3338 alcohol-dependent patients
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Ayahuasca blocks ethanol preference in an animal model of dependence and shows no acute toxicity
Gianfratti, B., Tabach, R., Sakalem, M. E., Stessuk, T., Maia, L. O., & Carlini, E. A. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114865 · Cited by 25 · see citing works
Role of 5-HT2A receptors in the effects of ayahuasca on ethanol self-administration using a two-bottle choice paradigm in male mice
Serra, Y. A., Barros-Santos, T., Anjos-Santos, A., Kisaki, N. D., Jovita-Farias, C., Leite, J. P., Santana, M. C. E., Coimbra, J. P. S. A., de Jesus, N. M. S., Sulima, A., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06104-w · Cited by 27 · see citing works
Self-citation
Single Ayahuasca administration attenuates alcohol relapse and associated behavioral, neurochemical, and oxidative alterations in rats
Lodetti, G., de Bitencourt, R. M., Inserra, A., Redivo, H., Teixeira, A. G., de Farias, A. C. S., Pickler, K. D. P., Rohling, J. P. V., Endler, A. T., Zampronio, E. P., et al. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111817

Authors: Oliveira-Lima, A. J., Santos, R., Hollais, A. W., Gerardi-Junior, C. A., Baldaia, M. A., Wuo-Silva, R., Yokoyama, T. S., Costa, J. L., Malpezzi-Marinho, E. L. A., Ribeiro-Barbosa, P. C., Berro, L. F., Frussa-Filho, R., & Marinho, E. A. V.
Affiliations: Universidade Estadual de Santa Cruz (BR)
Universidade Federal de São Paulo (BR)
Universidade Braz Cubas (BR)
Corresponding author: Berro, L.F.
Marinho, E.A.V.
ORCID: Santos, R.
Hollais, A.W.
Costa, J.L.
Malpezzi-Marinho, E.L.A.
Berro, L.F.
Marinho, E.A.V.
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 2015-04
Volume: 142
Pages: 28-36
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/j.physbeh.2015.01.032
OpenAlex: W2086022256
Cited by: 91
References: 54
Citations by year: 2026: 3 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 14 · 2021: 13 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 9 · 2015: 2
FWCI: 3.27
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 307 d)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders: Fundação de Amparo a Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
CAPES
Fundo de Auxílio aos Docentes e Alunos (FADA/UNIFESP)
Associação Fundo de Incentivo à Pesquisa (AFIP)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: ayahuasca, locomotor sensitization, hallucinogens, alcoholism treatment
MeSH terms: Ethanol, Animals, Central Nervous System Depressants, Dose-Response Relationship, Drug, Exploratory Behavior, Hallucinogens, Male, Phytotherapy, Motor Activity, Akathisia, Drug-Induced, Plant Preparations, Banisteriopsis, Mice

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Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice.

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