The current state of research on ayahuasca: a systematic review of human studies assessing psychiatric symptoms, neuropsychological functioning, and neuroimaging

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042 · see citing works

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.

(2009) · PubMed Central · Cited by 44,859 · see citing works

Diagnostic and Statistical Manual of Mental Disorders.

Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,767 · see citing works

Dynamic mapping of human cortical development during childhood through early adulthood

Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604 · see citing works

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works

Wandering minds: the default network and stimulus-independent thought

Mason, M. F., Norton, M. I., Van Horn, J. D., Wegner, D. M., Grafton, S. T., & Macrae, C. N. (2007) · Science · doi:10.1126/science.1131295 · Cited by 2,792 · see citing works

The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs.

Carhart-Harris, R. L., Leech, R., Hellyer, P. J., Shanahan, M., Feilding, A., Tagliazucchi, E., Chialvo, D. R., & Nutt, D. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00020 · Cited by 1,252 · see citing works

Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer

Grob, C. S., Danforth, A. L., Chopra, G. S., Hagerty, M., McKay, C. R., Halberstadt, A. L., & Greer, G. R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.116 · Cited by 1,206 · see citing works

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin

Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., Tyacke, R. J., Leech, R., Malizia, A. L., Murphy, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119598109 · Cited by 1,172 · see citing works

Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

Bogenschutz, M. P., Forcehimes, A. A., Pommy, J. A., Wilcox, C. E., Barbosa, P., & Strassman, R. J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114565144 · Cited by 1,151 · cited 1× · see citing works

Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action

Vollenweider, F. X., Vollenweider-Scherpenhuyzen, M. F. I., Bäbler, A., Vogel, H., & Hell, D. (1998) · NeuroReport · doi:10.1097/00001756-199812010-00024 · Cited by 1,018 · see citing works

Pilot study of the 5-HT _2A R agonist psilocybin in the treatment of tobacco addiction

Johnson, M. W., Garcia-Romeu, A., Cosimano, M. P., & Griffiths, R. R. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114548296 · Cited by 914 · cited 1× · see citing works

Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder

Moreno, F. A., Wiegand, C. B., Taitano, E. K., & Delgado, P. L. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1110 · Cited by 789 · see citing works

Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases

Gasser, P., Holstein, D., Michel, Y., Doblin, R., Yazar-Klosinski, B., Passie, T., & Brenneisen, R. (2014) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0000000000000113 · Cited by 750 · see citing works

The neurobiology of psychedelic drugs: implications for the treatment of mood disorders

Vollenweider, F. X., & Kometer, M. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2884 · Cited by 723 · see citing works

Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies

Studerus, E., Kometer, M., Hasler, F., & Vollenweider, F. X. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110382466 · Cited by 532 · see citing works

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Osório, F. D. L., Sanches, R. F., Macedo, L. R., dos Santos, R. G., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A., & Hallak, J. E. (2015) · Revista Brasileira de Psiquiatria · doi:10.1590/1516-4446-2014-1496 · Cited by 488 · see citing works

Plants of the Gods: Their Sacred, Healing and Hallucinogenic Powers

Hofmann, A., & Schultes, R. E. (1992) · Medical Entomology and Zoology · Cited by 469 · see citing works

Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression: A SPECT Study

Sanches, R. F., de Lima Osório, F., dos Santos, R. G., Macedo, L. R. H., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000436 · Cited by 466 · see citing works

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

Muthukumaraswamy, S. D., Carhart-Harris, R. L., Moran, R., Brookes, M. J., Williams, T. M., Errtizoe, D., Sessa, B., Papadopoulos, A., Bolstridge, M., Singh, K. D., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2063-13.2013 · Cited by 465 · see citing works

The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network

Palhano-Fontes, F., Andrade, K. C., Tofoli, L. F., Santos, A. C., Crippa, J. A. S., Hallak, J. E. C., Ribeiro, S., & de Araujo, D. B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118143 · Cited by 454 · see citing works

Dose-response study of N,N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale.

Strassman, R. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020022002 · Cited by 453 · see citing works

Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study

Hasler, F., Grimberg, U., Benz, M. A., Huber, T., & Vollenweider, F. X. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1640-6 · Cited by 451 · see citing works

Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis

Vollenweider, F. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00246-1 · Cited by 444 · see citing works

Serotonin research: contributions to understanding psychoses

GEYER, M., & VOLLENWEIDER, F. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.06.006 · Cited by 427 · see citing works

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

Schmid, Y., Enzler, F., Gasser, P., Grouzmann, E., Preller, K. H., Vollenweider, F. X., Brenneisen, R., Müller, F., Borgwardt, S., & Liechti, M. E. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.015 · Cited by 409 · see citing works

Monoamine oxidase inhibitors in South American hallucinogenic plants: Tryptamine and β-carboline constituents of ayahuasca

McKenna, D. J., Towers, G. H. N., & Abbott, F. (1984) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(84)90003-5 · Cited by 398 · see citing works

Human pharmacology of ayahuasca: Subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics

Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., & Barbanoj, M. J. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049882 · Cited by 390 · see citing works

A systems model of altered consciousness: integrating natural and drug-induced psychoses

Vollenweider, F. X., & Geyer, M. A. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00646-3 · Cited by 339 · see citing works

Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil.

GROB, C. S., McKENNA, D. J., CALLAWAY, J. C., BRITO, G. S., NEVES, E. S., OBERLAENDER, G., SAIDE, O. L., LABIGALINI, E., TACLA, C., MIRANDA, C. T., et al. (1996) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199602000-00004 · Cited by 338 · see citing works

Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada

Thomas, G., Lucas, P., Capler, N., Tupper, K., & Martin, G. (2013) · Current Drug Abuse Reviews · doi:10.2174/15733998113099990003 · Cited by 330 · see citing works

Psilocybin-induced decrease in amygdala reactivity correlates with enhanced positive mood in healthy volunteers

Kraehenmann, R., Preller, K. H., Scheidegger, M., Pokorny, T., Bosch, O. G., Seifritz, E., & Vollenweider, F. X. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.010 · Cited by 323 · see citing works

Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of ayahuasca: a longitudinal study.

Bouso, J. C., González, D., Fondevila, S., Cutchet, M., Fernández, X., Ribeiro Barbosa, P. C., Alcázar-Córcoles, M. Á., Araújo, W. S., Barbanoj, M. J., Fábregas, J. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042421 · Cited by 313 · see citing works

Subjective effects and tolerability of the South American psychoactive beverage ayahuasca in healthy volunteers

Riba, J., Rodríguez-Fornells, A., Urbano, G., Morte, A., Antonijoan, R., Montero, M., Callaway, J. C., & Barbanoj, M. J. (2001) · Psychopharmacology · doi:10.1007/s002130000606 · Cited by 303 · see citing works

Psilocybin Biases Facial Recognition, Goal-Directed Behavior, and Mood State Toward Positive Relative to Negative Emotions Through Different Serotonergic Subreceptors

Kometer, M., Schmidt, A., Bachmann, R., Studerus, E., Seifritz, E., & Vollenweider, F. X. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.005 · Cited by 298 · see citing works

Qualidade de vida e espiritualidade

Panzini, R. G., da Rocha, N. S., Bandeira, D. R., & Fleck, M. P. D. A. (2007) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/s0101-60832007000700014 · Cited by 288 · see citing works

LYSERGIC ACID DIETHYLAMIDE: SIDE EFFECTS AND COMPLICATIONS

COHEN, S. (1960) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-196001000-00005 · Cited by 287 · see citing works

ADVERSE REACTIONS TO PSYCHEDELIC DRUGS. A REVIEW OF THE LITERATURE

Strassman, R. (1984) · Journal of Nervous and Mental Disease · doi:10.1097/00005053-198410000-00001 · Cited by 280 · see citing works

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Carhart-Harris, R. L., Leech, R., Erritzoe, D., Williams, T. M., Stone, J. M., Evans, J., Sharp, D. J., Feilding, A., Wise, R. G., & Nutt, D. J. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs117 · Cited by 256 · see citing works

Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids.

Gable, R. S. (2007) · Addiction · doi:10.1111/j.1360-0443.2006.01652.x · Cited by 244 · see citing works

Increased frontal and paralimbic activation following ayahuasca, the pan-amazonian inebriant

Riba, J., Romero, S., Grasa, E., Mena, E., Carrió, I., & Barbanoj, M. J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0358-7 · Cited by 241 · see citing works

Effects of psilocybin on time perception and temporal control of behaviour in humans

Wittmann, M., Carter, O. L., Hasler, F., Cahn, B. R., Grimberg, U., Spring, P., Hell, D., Flohr, H., & Vollenweider, F. X. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106065859 · Cited by 240 · see citing works

Seeing with the eyes shut: neural basis of enhanced imagery following ayahuasca ingestion.

de Araujo, D. B., Ribeiro, S., Cecchi, G. A., Carvalho, F. M., Sanchez, T. A., Pinto, J. P., de Martinis, B. S., Crippa, J. A., Hallak, J. E. C., & Santos, A. C. (2012) · Human Brain Mapping · doi:10.1002/hbm.21381 · Cited by 239 · see citing works

Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin

Carhart-Harris, R. L., Leech, R., Williams, T. M., Erritzoe, D., Abbasi, N., Bargiotas, T., Hobden, P., Sharp, D. J., Evans, J., Feilding, A., et al. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.103309 · Cited by 237 · see citing works

Using Psilocybin to Investigate the Relationship between Attention, Working Memory, and the Serotonin 1A and 2A Receptors

Carter, O. L., Burr, D. C., Pettigrew, J. D., Wallis, G. M., Hasler, F., & Vollenweider, F. X. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/089892905774597191 · Cited by 231 · see citing works

Assessment of addiction severity among ritual users of ayahuasca.

Fábregas, J. M., González, D., Fondevila, S., Cutchet, M., Fernández, X., Barbosa, P. C. R., Alcázar-Córcoles, M. Á., Barbanoj, M. J., Riba, J., & Bouso, J. C. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.03.024 · Cited by 227 · see citing works

Classic hallucinogens in the treatment of addictions

Bogenschutz, M. P., & Johnson, M. W. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.002 · Cited by 226 · see citing works

Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans.

Bouso, J. C., Palhano-Fontes, F., Rodríguez-Fornells, A., Ribeiro, S., Sanches, R., Crippa, J. A. S., Hallak, J. E. C., de Araujo, D. B., & Riba, J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.008 · Cited by 218 · see citing works

Exploring the therapeutic potential of Ayahuasca: acute intake increases mindfulness-related capacities

Soler, J., Elices, M., Franquesa, A., Barker, S., Friedlander, P., Feilding, A., Pascual, J. C., & Riba, J. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4162-0 · Cited by 209 · see citing works

Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members

SANTOS, R. G. D., Landeira-Fernández, J., Strassman, R. J., Motta, V., & Cruz, A. P. D. M. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.04.012 · Cited by 205 · see citing works

Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum

Glick, S. D., Kuehne, M. E., Raucci, J., Wilson, T. E., Larson, D. M., Keller, R. W., & Carlson, J. N. (1994) · Brain Research · doi:10.1016/0006-8993(94)90948-2 · Cited by 190 · see citing works

Effects of the 5-HT2A Agonist Psilocybin on Mismatch Negativity Generation and AX-Continuous Performance Task: Implications for the Neuropharmacology of Cognitive Deficits in Schizophrenia

Umbricht, D., Vollenweider, F. X., Schmid, L., Grübel, C., Skrabo, A., Huber, T., & Koller, R. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300005 · Cited by 187 · see citing works

Psychological and Cognitive Effects of Long-Term Peyote Use Among Native Americans

Halpern, J. H., Sherwood, A. R., Hudson, J. I., Yurgelun-Todd, D. A., & Pope, H. G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.038 · Cited by 187 · see citing works

Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: Experimental psychosis as a tool for psychiatric research

Hermle, L., Fünfgeld, M., Oepen, G., Botsch, H., Borchardt, D., Gouzoulis, E., Fehrenbach, R. A., & Spitzer, M. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90059-9 · Cited by 183 · see citing works

Psychedelics and schizophrenia

González‐Maeso, J., & Sealfon, S. C. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.005 · Cited by 168 · see citing works

World drug report 2014

United Nations Office on Drugs and Crime (2014) · World drug report · doi:10.18356/bdf42380-en · Cited by 166 · see citing works

Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies

SANTOS, R. G. D., Osório, F. D. L., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2015-1701 · Cited by 163 · see citing works

Therapeutic Effects of Ritual Ayahuasca Use in the Treatment of Substance Dependence—Qualitative Results

Loizaga-Velder, A. K., & Verres, R. (2014) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2013.873157 · Cited by 157 · see citing works

Mismatch negativity generation in the human 5HT2A agonist and NMDA antagonist model of psychosis

Heekeren, K., Daumann, J., Neukirch, A., Stock, C., Kawohl, W., Norra, C., Waberski, T. D., & Gouzoulis‐Mayfrank, E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1129-4 · Cited by 152 · see citing works

Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus

Fortunato, J. J., Réus, G. Z., Kirsch, T. R., Stringari, R. B., Stertz, L., Kapczinski, F., Pinto, J. P., Hallak, J. E., Zuardi, A. W., Crippa, J. A., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.021 · Cited by 150 · see citing works

Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson's disease

Samoylenko, V., Rahman, M. M., Tekwani, B. L., Tripathi, L. M., Wang, Y.-H., Khan, S. I., Khan, I. A., Miller, L. S., Joshi, V. C., & Muhammad, I. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.10.030 · Cited by 148 · see citing works

The Therapeutic Use of Ayahuasca

Labate, B. C., & Cavnar, C. (2013) · Springer eBooks · doi:10.1007/978-3-642-40426-9 · Cited by 141 · see citing works

Pharmacology of ayahuasca administered in two repeated doses

dos Santos, R. G., Grasa, E., Valle, M., Ballester, M. R., Bouso, J. C., Nomdedéu, J. F., Homs, R., Barbanoj, M. J., & Riba, J. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2434-x · Cited by 141 · see citing works

Ayahuasca Preparations and Serotonin Reuptake Inhibitors: A Potential Combination for Severe Adverse Interactions

Callaway, J. C., & Grob, C. S. (1998) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1998.10399712 · Cited by 137 · see citing works

Autonomic, Neuroendocrine, and Immunological Effects of Ayahuasca

SANTOS, R. G. D., Valle, M., Bouso, J. C., Nomdedeu, J. F., Rodrı́guez-Espinosa, J., McIlhenny, E. H., Barker, S. A., Barbanoj, M. J., & Riba, J. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31823607f6 · Cited by 136 · see citing works

Drug models of schizophrenia

Steeds, H., Carhart-Harris, R. L., & Stone, J. M. (2014) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125314557797 · Cited by 134 · see citing works

Effects of the South American Psychoactive Beverage Ayahuasca on Regional Brain Electrical Activity in Humans: A Functional Neuroimaging Study Using Low-Resolution Electromagnetic Tomography

Jordi Riba, A., Anderer, P., Jané, F., Saletu, B., & Barbanoj, M. J. (2004) · Neuropsychobiology · doi:10.1159/000077946 · Cited by 130 · see citing works

Untitled work

(2008) · PubMed · Cited by 130 · see citing works

Psychedelics as Medicines for Substance Abuse Rehabilitation: Evaluating Treatments with LSD, Peyote, Ibogaine and Ayahuasca

Winkelman, M. (2015) · Current Drug Abuse Reviews · doi:10.2174/1874473708666150107120011 · Cited by 126 · see citing works

Therapeutic mechanisms of classic hallucinogens in the treatment of addictions: from indirect evidence to testable hypotheses

Bogenschutz, M. P., & Pommy, J. M. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1376 · Cited by 125 · see citing works

The Internationalization of Ayahuasca

MacRae, E. (2012) · Journal of Contemporary Religion · doi:10.1080/13537903.2012.722324 · Cited by 125 · see citing works

Topographic pharmaco‐EEG mapping of the effects of the South American psychoactive beverage <i>ayahuasca</i> in healthy volunteers

Riba, J., Anderer, P., Morte, A., Urbano, G., Jané, F., Saletu, B., & Barbanoj, M. J. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01609.x · Cited by 125 · see citing works

Report on psychoactive drug use among adolescents using ayahuasca within a religious context.

Doering-Silveira, E., Grob, C. S., de Rios, M. D., Lopez, E., Alonso, L. K., Tacla, C., & Da Silveira, D. X. (2005) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2005.10399794 · Cited by 122 · see citing works

Classical hallucinogens as antidepressants? A review of pharmacodynamics and putative clinical roles

Baumeister, D., Barnes, G. L., Giaroli, G., & Tracy, D. K. (2014) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125314527985 · Cited by 121 · see citing works

‘Altered States of Consciousness and Short-Term Psychological After-Effects Induced by the First Time Ritual Use of Ayahuasca in an Urban Context in Brazil’

Barbosa, P. C. R., Giglio, J. S., & Dalgalarrondo, P. (2005) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2005.10399801 · Cited by 120 · see citing works

Modulating the Rate and Rhythmicity of Perceptual Rivalry Alternations with the Mixed 5-HT2A and 5-HT1A Agonist Psilocybin

Carter, O. L., Pettigrew, J. D., Hasler, F., Wallis, G. M., Liu, G. B., Hell, D., & Vollenweider, F. X. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300621 · Cited by 118 · see citing works

Ayahuasca in Adolescence: A Preliminary Psychiatric Assessment

Da Silveira, D. X., Grob, C. S., de Rios, M. D., Lopez, E., Alonso, L. K., Tacla, C., & Doering-Silveira, E. (2005) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2005.10399792 · Cited by 113 · see citing works

Health status of ayahuasca users

Barbosa, P. C. R., Mizumoto, S., Bogenschutz, M. P., & Strassman, R. J. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1383 · Cited by 112 · see citing works

Acute biphasic effects of ayahuasca.

Schenberg, E. E., Alexandre, J. F. M., Filev, R., Cravo, A. M., Sato, J. R., Muthukumaraswamy, S. D., Yonamine, M., Waguespack, M., Lomnicka, I., Barker, S. A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137202 · Cited by 111 · see citing works

Acute Adverse Reactions to Lsd in Clinical and Experimental use in the United Kingdom

Malleson, N. (1971) · British Journal of Psychiatry · doi:10.1192/bjp.118.543.229 · Cited by 111 · see citing works

A Six-Month Prospective Evaluation of Personality Traits, Psychiatric Symptoms and Quality of Life in Ayahuasca-Naïve Subjects

Barbosa, P. C. R., Cazorla, I. M., Giglio, J. S., & Strassman, R. J. (2009) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2009.10400530 · Cited by 108 · see citing works

Behavioural and neurotoxic effects of ayahuasca infusion (Banisteriopsis caapi and Psychotria viridis) in female Wistar rat

Pic‐Taylor, A., da Motta, L. G., de Morais, J. A., Melo, W., Santos, A. D. F. A., Campos, L. A., Mortari, M. R., von Zuben, M. V., & Caldas, E. D. (2015) · Behavioural Processes · doi:10.1016/j.beproc.2015.05.004 · Cited by 102 · see citing works

Serotonergic psychedelics temporarily modify information transfer in humans.

Alonso, J. F., Romero, S., Mañanas, M. À., & Riba, J. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv039 · Cited by 101 · see citing works

Metabolism and urinary disposition of N,N‐dimethyltryptamine after oral and smoked administration: a comparative study

Jordi Riba, A., McIlhenny, E. H., Bouso, J. C., & Barker, S. A. (2014) · Drug Testing and Analysis · doi:10.1002/dta.1685 · Cited by 98 · see citing works

Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus

Fortunato, J. J., Réus, G. Z., Kirsch, T. R., Stringari, R. B., Fries, G. R., Kapczinski, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Quevedo, J. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0451-2 · Cited by 98 · see citing works

Activities of extract and constituents of Banisteriopsis caapi relevant to parkinsonism

Schwarz, M. J., Houghton, P. J., Rose, S., Jenner, P. G., & Lees, A. J. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00129-1 · Cited by 98 · see citing works

Acute effects of ayahuasca on neuropsychological performance: differences in executive function between experienced and occasional users

Bouso, J. C., Fábregas, J. M., Antonijoan, R. M., Rodríguez-Fornells, A., & Riba, J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3167-9 · Cited by 96 · see citing works

Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice.

Oliveira-Lima, A. J., Santos, R., Hollais, A. W., Gerardi-Junior, C. A., Baldaia, M. A., Wuo-Silva, R., Yokoyama, T. S., Costa, J. L., Malpezzi-Marinho, E. L. A., Ribeiro-Barbosa, P. C., et al. (2015) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2015.01.032 · Cited by 91 · see citing works

Safety and Side Effects of Ayahuasca in Humans—An Overview Focusing on Developmental Toxicology

SANTOS, R. G. D. (2013) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2013.763564 · Cited by 87 · see citing works

Enhancement of creative expression and entoptic phenomena as after-effects of repeated ayahuasca ceremonies

Frecska, E., Móré, C. E., Vargha, A., & Luna, L. E. (2012) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2012.703099 · Cited by 87 · see citing works

Psilocybin impairs high-level but not low-level motion perception

Carter, O. L., Pettigrew, J. D., Burr, D. C., Alais, D., Hasler, F., & Vollenweider, F. X. (2004) · Neuroreport · doi:10.1097/00001756-200408260-00023 · Cited by 84 · see citing works

Unfavourable reactions to LSD: a review and analysis of the available case reports.

Smart, R. G., & Bateman, K. (1967) · PubMed · Cited by 78 · see citing works

Hypotheses Regarding the Mechanisms of Ayahuasca in the Treatment of Addictions

Liester, M. B., & Prickett, J. I. (2012) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2012.704590 · Cited by 77 · see citing works

Ayahuasca in Adolescence: A Neuropsychological Assessment

Doering-Silveira, E., López, E., Grob, C. S., de Ríos, M. D., Alonso, L. K., Tacla, C., Shirakawa, I., Bertolucci, P. H. F., & da Silveira, D. X. (2005) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2005.10399791 · Cited by 72 · see citing works

Dimethyltryptamine (DMT): Subjective effects and patterns of use among Australian recreational users

Cakic, V., Potkonyak, J., & Marshall, A. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.03.015 · Cited by 72 · see citing works

Effects of ayahuasca on sensory and sensorimotor gating in humans as measured by P50 suppression and prepulse inhibition of the startle reflex, respectively

Jordi Riba, A., Rodríguez‐Fornells, A., & Barbanoj, M. J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1237-5 · Cited by 70 · see citing works

Complications Associated with Lysergic Acid Diethylamide (LSD-25)

Cohen, S. (1962) · JAMA · doi:10.1001/jama.1962.03050280091013b · Cited by 66 · see citing works

Neuronal correlates of visual and auditory alertness in the DMT and ketamine model of psychosis

Daumann, J., Wagner, D. R., Heekeren, K., Neukirch, A., Thiel, C. M., & Gouzoulis‐Mayfrank, E. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109103227 · Cited by 62 · see citing works

Serotonergic Hallucinogens and Emerging Targets for Addiction Pharmacotherapies

Ross, S. (2012) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.04.002 · Cited by 54 · see citing works

Pharmacological modulation of the neural basis underlying inhibition of return (IOR) in the human 5-HT2A agonist and NMDA antagonist model of psychosis

Daumann, J., Heekeren, K., Neukirch, A., Thiel, C. M., Möller‐Hartmann, W., & Gouzoulis‐Mayfrank, E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1237-1 · Cited by 52 · see citing works

Prepulse inhibition of the startle reflex and its attentional modulation in the human S-ketamine and N,N-dimethyltryptamine (DMT) models of psychosis

Heekeren, K., Neukirch, A., Daumann, J., Stoll, M., Obradovic, M., Kovar, K. ‐., Geyer, M. A., & Gouzoulis‐Mayfrank, E. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107077734 · Cited by 50 · see citing works

A Critical Evaluation of Reports Associating Ayahuasca with Life-Threatening Adverse Reactions

SANTOS, R. G. D. (2013) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2013.785846 · Cited by 47 · see citing works

Effects of harman and harmine on naloxone-precipitated withdrawal syndrome in morphine-dependent rats

Aricioǧlu-Kartal, F., Kayır, H., & Uzbay, T. I. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00647-7 · Cited by 45 · see citing works

Harmine augments electrically evoked dopamine efflux in the nucleus accumbens shell

Brierley, D. I., & Davidson, C. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112463125 · Cited by 45 · see citing works

Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report

Szmulewicz, A., Valerio, M. P., & Smith, J. M. (2015) · International Journal of Bipolar Disorders · doi:10.1186/s40345-014-0020-y · Cited by 45 · see citing works

Chronic treatment with LY341495 decreases 5-HT2A receptor binding and hallucinogenic effects of LSD in mice

Moreno, J. L., Holloway, T. D., Rayannavar, V., Sealfon, S. C., & González‐Maeso, J. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2012.12.053 · Cited by 44 · see citing works

Maternal and developmental toxicity of ayahuasca in Wistar rats

de Oliveira, C. D. R., Moreira, C. Q., de Sá, L. R. M., Spinosa, H. D. S., & Yonamine, M. (2010) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20244 · Cited by 44 · see citing works

Experience of Treatment with Ayahuasca for Drug Addiction in the Brazilian Amazon

Fernández, X., & Fábregas, J. M. (2013) · Springer eBooks · doi:10.1007/978-3-642-40426-9_10 · Cited by 37 · see citing works

Assessment of the Psychotherapeutic Effects of Ritual Ayahuasca Use on Drug Dependency: A Pilot Study

Fernández, X., dos Santos, R. G., Cutchet, M., Fondevila, S., González, D., Alcázar, M. Á., Riba, J., Bouso, J. C., & María Fábregas, J. (2014) · The Therapeutic Use of Ayahuasca · doi:10.1007/978-3-642-40426-9_11 · Cited by 36 · see citing works

Clinical syndromes and biochemical alterations following mescaline, lysergic acid diethylamide, psilocybin and a combination of the three psychotomimetic drugs

Hollister, L. E., & Sjoberg, B. M. (1964) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(64)80030-4 · Cited by 36 · see citing works

Consumption of Ayahuasca by Children and Pregnant Women: Medical Controversies and Religious Perspectives

Labate, B. C. (2011) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2011.566498 · Cited by 33 · see citing works

Effects of ayahuasca on binocular rivalry with dichoptic stimulus alternation.

Frecska, E., White, K. D., & Luna, L. E. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1701-x · Cited by 32 · see citing works

Therapist and Patient Perspectives on Ayahuasca-Assisted Treatment for Substance Dependence

Loizaga-Velder, A. K., & Pazzi, A. L. (2013) · Springer eBooks · doi:10.1007/978-3-642-40426-9_8 · Cited by 31 · see citing works

Santo Daime and Santa Maria – The licit ritual use of ayabuasca and the illicit use of cannabis in a Brazilian Amazonian religion

MacRae, E. (1998) · International Journal of Drug Policy · doi:10.1016/s0955-3959(98)00045-0 · Cited by 24 · see citing works

O Uso Ritual Da Ayahuasca

GOW, P. (2004) · American Anthropologist · doi:10.1525/aa.2004.106.3.624 · Cited by 24 · see citing works

In vivo comparison of harmine efficacy against psychostimulants: Preferential inhibition of the cocaine response through a glutamatergic mechanism

Owaisat, S., Raffa, R. B., & Rawls, S. M. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.07.052 · Cited by 20 · see citing works

The adverse effects of hallucinogens from intramural perspective.

Frecska, E., & Luna, L. E. (2006) · PubMed · Cited by 16 · see citing works

Effect of Santo Daime Membership on Substance Dependence

Labate, B. C., SANTOS, R. G. D., Strassman, R. J., Anderson, B. T., & Mizumoto, S. (2013) · Springer eBooks · doi:10.1007/978-3-642-40426-9_9 · Cited by 13 · see citing works

Toxicity of chronic ayahuasca administration to the pregnant rat: how relevant it is regarding the human, ritual use of ayahuasca?

SANTOS, R. G. D. (2010) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20272 · Cited by 10 · see citing works

Ayahuasca versus violence--a case report.

Frecska, E. (2008) · PubMed · Cited by 10 · see citing works

Letter to the Editor

SANTOS, R. G. D., Osório, F. D. L., Crippa, J. A. S., Bouso, J. C., & Hallak, J. E. C. (2015) · Journal of Forensic and Legal Medicine · doi:10.1016/j.jflm.2015.11.009 · Cited by 1 · see citing works

Psychedelics and Psychedelic-Assisted Psychotherapy

Reiff, C. M., Richman, E. E., Nemeroff, C. B., Carpenter, L. L., Widge, A. S., Rodriguez, C. I., Kalin, N. H., McDonald, W. M., & and the Work Group on Biomarkers and Novel Treatments, A. D. O. T. A. P. A. C. O. R. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19010035 · Cited by 649 · see citing works

Therapeutic effects of classic serotonergic psychedelics: a systematic review of modern-era clinical studies

Andersen, K. A. A., Carhart‐Harris, R., Nutt, D. J., & Erritzoe, D. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13249 · Cited by 347 · see citing works

Efficacy, tolerability, and safety of serotonergic psychedelics for the management of mood, anxiety, and substance-use disorders: a systematic review of systematic reviews

SANTOS, R. G. D., Bouso, J. C., Alcázar‐Córcoles, M. Á., & Hallak, J. E. C. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1511424 · Cited by 228 · see citing works

Adverse events in clinical treatments with serotonergic psychedelics and MDMA: a mixed-methods systematic review.

Breeksema, J. J., Kuin, B. W., Kamphuis, J., van den Brink, W., Vermetten, E., & Schoevers, R. A. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221116926 · Cited by 178 · see citing works

Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness

Hamill, J., Hallak, J. E. C., Dursun, S. M., & Baker, G. B. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180125095902 · Cited by 182 · see citing works

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function

Barker, S. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00536 · Cited by 177 · see citing works

Ayahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies

SANTOS, R. G. D., Bouso, J. C., & Hallak, J. E. C. (2017) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316689030 · Cited by 168 · see citing works

Serotonergic psychedelics and personality: A systematic review of contemporary research

Bouso, J. C., dos Santos, R. G., Alcázar-Córcoles, M. Á., & Hallak, J. E. C. (2018) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.004 · Cited by 134 · see citing works

Epidemiology of hallucinogen use in the U.S. results from the National epidemiologic survey on alcohol and related conditions III

Shalit, N., Rehm, J. T., & Lev‐Ran, S. (2018) · Addictive Behaviors · doi:10.1016/j.addbeh.2018.09.020 · Cited by 129 · see citing works

Subacute effects of the psychedelic ayahuasca on the salience and default mode networks

Pasquini, L., Palhano-Fontes, F., & de Araújo, D. B. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120909409 · Cited by 115 · see citing works

Toxicokinetics and Toxicodynamics of Ayahuasca alkaloids N,N-dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: clinical and forensic impact

Brito-da-Costa, A. M., Dias-da-Silva, D., Gomes, N. G. M., Dinis-Oliveira, R. J., & Madureira-Carvalho, Á. (2020) · Pharmaceuticals · doi:10.3390/ph13110334 · Cited by 117 · see citing works

Dark Classics in Chemical Neuroscience:N,N-Dimethyltryptamine (DMT)

Cameron, L. P., & Olson, D. E. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00101 · Cited by 117 · see citing works

Therapeutic use of serotoninergic hallucinogens: A review of the evidence and of the biological and psychological mechanisms

dos Santos, R. G., & Hallak, J. E. C. (2020) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.001 · Cited by 111 · see citing works

Ayahuasca Improves Self-perception of Speech Performance in Subjects With Social Anxiety Disorder

SANTOS, R. G. D., Osório, F. D. L., Rocha, J. M., Rossi, G. N., Bouso, J. C., Rodrigues, L. S., Silveira, G. D. O., Yonamine, M., & Hallak, J. E. C. (2021) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001428 · Cited by 91 · see citing works

Well-being, problematic alcohol consumption and acute subjective drug effects in past-year ayahuasca users: a large, international, self-selecting online survey

Lawn, W., Hallak, J. E. C., Crippa, J. A. S., SANTOS, R. G. D., Porffy, L., Barratt, M. J., Ferris, J., WINSTOCK, A. R., & Morgan, C. J. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-14700-6 · Cited by 78 · see citing works

Therapeutic potential of ayahuasca in grief: a prospective, observational study

González, D., Cantillo, J., Pérez, I., Farré, M., Feilding, A., Obiols, J. E., & Bouso, J. C. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05446-2 · Cited by 75 · see citing works

Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT

Barker, S. A. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06065-0 · Cited by 58 · see citing works

Chemical composition of traditional and analog Ayahuasca

Kaasik, H., Souza, R. C. Z., Zandonadi, F. S., Tófoli, L. F., & Sussulini, A. (2021) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2020.1815911 · Cited by 59 · see citing works

Psychological variables implied in the therapeutic effect of ayahuasca: A contextual approach

Franquesa, A., Sainz-Cort, A., Gandy, S., Soler, J., Alcázar-Córcoles, M. Á., & Bouso, J. C. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.04.012 · Cited by 58 · see citing works

Modulatory effects of ayahuasca on personality structure in a traditional framework

Netzband, N., Ruffell, S., Linton, S., Tsang, W., & Wolff, T. J. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05601-0 · Cited by 58 · see citing works

Psychedelic drug use in healthy individuals: a review of benefits, costs, and implications for drug policy

Elsey, J. W. B. (2017) · Drug Science Policy and Law · doi:10.1177/2050324517723232 · Cited by 57 · see citing works

Ayahuasca, an ancient substance with traditional and contemporary use in neuropsychiatry and neuroscience

SANTOS, R. G. D., & Hallak, J. E. C. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.04.053 · Cited by 56 · see citing works

Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Oslo, Norway

Vallersnes, O. M., Persett, P. S., Øiestad, E. L., Karinen, R., Heyerdahl, F., & Hovda, K. E. (2017) · Clinical Toxicology · doi:10.1080/15563650.2017.1312002 · Cited by 54 · see citing works

Ayahuasca: A review of historical, pharmacological, and therapeutic aspects

Ruffell, S., Crosland‐Wood, M., Palmer, R., Netzband, N., Tsang, W., Weiss, B., Gandy, S., Cowley‐Court, T., Halman, A., McHerron, D., et al. (2023) · Psychiatry and Clinical Neurosciences Reports · doi:10.1002/pcn5.146 · Cited by 54 · see citing works

Effects of ayahuasca and its alkaloids on substance use disorders: an updated (2016–2020) systematic review of preclinical and human studies

Rodrigues, L. S., Rossi, G. N., Rocha, J. M., Osório, F. D. L., Bouso, J. C., Hallak, J. E. C., & SANTOS, R. G. D. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01267-7 · Cited by 46 · see citing works

Ayahuasca's therapeutic potential: What we know – and what not

Maia, L. O., Daldegan‐Bueno, D., Wießner, I., de Araújo, D. B., & Tófoli, L. F. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.10.008 · Cited by 47 · see citing works

N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine

James, E., Keppler, J., Robertshaw, T. L., & Sessa, B. (2022) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2835 · Cited by 43 · see citing works

Psychoactive Substances of Natural Origin: Toxicological Aspects, Therapeutic Properties and Analysis in Biological Samples

Gonçalves, J., Luís, Â., Gallardo, E., & Duarte, A. P. (2021) · Molecules · doi:10.3390/molecules26051397 · Cited by 40 · see citing works

Toxicological Aspects and Determination of the Main Components of Ayahuasca: A Critical Review

Simão, A. Y., Gonçalves, J., Duarte, A. P., Barroso, M., Cristóvão, A. C., & Gallardo, E. (2019) · Medicines · doi:10.3390/medicines6040106 · Cited by 40 · see citing works

Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up

SANTOS, R. G. D., Sanches, R. F., Osório, F. D. L., & Hallak, J. E. C. (2018) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/0101-60830000000149 · Cited by 37 · see citing works

Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects

Aicher, H. D., Mueller, M. J., Dornbierer, D. A., Suay, D., Elsner, C., Wicki, I., Meling, D., Caflisch, L., Hempe, A., Steinhart, C., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1302559 · Cited by 33 · see citing works

How do serotonergic psychedelics treat depression: The potential role of neuroplasticity

Artin, H., Zisook, S., & Ramanathan, D. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i6.201 · Cited by 33 · see citing works

Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia

Okubo, R., Okada, M., & Motomura, E. (2024) · Biomolecules · doi:10.3390/biom14091128 · Cited by 35 · see citing works

Within-treatment changes in a novel addiction treatment program using traditional Amazonian medicine

O’Shaughnessy, D. M., Berlowitz, I., Rodd, R., Sarnyai, Z., & Quirk, F. H. (2021) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320986634 · Cited by 33 · see citing works

Psychedelic Cognition—The Unreached Frontier of Psychedelic Science

Bălăeţ, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.832375 · Cited by 30 · see citing works

The felt-presence experience: from cognition to the clinic

Barnby, J. M., Park, S., Baxter, T., Rosen, C., Brugger, P., & Alderson‐Day, B. (2023) · The Lancet Psychiatry · doi:10.1016/s2215-0366(23)00034-2 · Cited by 28 · see citing works

Psychotherapeutic and neurobiological processes associated with ayahuasca: A proposed model and implications for therapeutic use

Perkins, D., Ruffell, S., Day, K., Rubiano, D. P., & Sarris, J. J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.879221 · Cited by 30 · see citing works

How does ayahuasca work from a psychiatric perspective? Pros and cons of the entheogenic therapy

Orsolini, L., Chiappini, S., Papanti, D., Latini, R., Volpe, U., Fornaro, M., Tomasetti, C., Vellante, F., & Berardis, D. D. (2020) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2728 · Cited by 28 · see citing works

Ayahuasca Beverages: Phytochemical Analysis and Biological Properties

Gonçalves, J., Luís, Â., Gradillas, A., Garcı́a, A., Restolho, J., Fernández, N., Domingues, F., Gallardo, E., & Duarte, A. P. (2020) · Antibiotics · doi:10.3390/antibiotics9110731 · Cited by 29 · see citing works

Beyond serotonin: newer antidepressants in the future

Rakesh, G., Pae, C., & Masand, P. S. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1341310 · Cited by 25 · see citing works

Antidepressant and anxiolytic-like effects of ayahuasca in rats subjected to LPS-induced neuroinflammation

da Silva, M. G., Daros, G. C., Santos, F. P., Yonamine, M., & de Bitencourt, R. M. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114007 · Cited by 24 · see citing works

Amazonian Medicine and the Psychedelic Revival: Considering the “Dieta”

O’Shaughnessy, D. M., & Berlowitz, I. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.639124 · Cited by 22 · see citing works

Psychedelics and Psychedelic-Assisted Psychotherapy

Reiff, C. M., Richman, E. E., Nemeroff, C. B., Carpenter, L. L., Widge, A. S., Rodríguez, C. I., Kalin, N. H., & McDonald, W. M. (2021) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.19104 · Cited by 21 · see citing works

Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure

Santos, A. D. F. A., Vieira, A. L. S., Pic‐Taylor, A., & Caldas, E. D. (2017) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2017.01.006 · Cited by 21 · see citing works

Ayahuasca and the traveller: A scoping review of risks and possible benefits

Houle, S. K. D., Evans, D., Carter, C. A., & Schlagenhauf, P. (2021) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2021.102206 · Cited by 20 · see citing works

Ayahuasca, a potentially rapid acting antidepressant: focus on safety and tolerability

Rossi, G. N., Dias, I. C. D. S., Baker, G. B., Bouso, J. C., Dursun, S. M., Hallak, J. E. C., & SANTOS, R. G. D. (2022) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2054988 · Cited by 21 · see citing works

A Systematic Review on the Therapeutic Effects of Ayahuasca

Gonçalves, J., Luís, Â., Gallardo, E., & Duarte, A. P. (2023) · Plants · doi:10.3390/plants12132573 · Cited by 20 · see citing works

Ayahuasca and Dimethyltryptamine Adverse Events and Toxicity Analysis: A Systematic Thematic Review

White, E., Kennedy, T., Ruffell, S., Perkins, D., & Sarris, J. J. (2024) · International Journal of Toxicology · doi:10.1177/10915818241230916 · Cited by 21 · see citing works

Overcoming epistemic injustices in the biomedical study of ayahuasca: Towards ethical and sustainable regulation

Schenberg, E. E., & Gerber, K. (2022) · Transcultural Psychiatry · doi:10.1177/13634615211062962 · Cited by 20 · see citing works

The current state of ayahuasca research in animal models: A systematic review

Daldegan‐Bueno, D., Simionato, N. M., Favaro, V. M., & Maia, L. O. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110738 · Cited by 20 · see citing works

Who are you after psychedelics? A systematic review and a meta-analysis of the magnitude of long-term effects of serotonergic psychedelics on cognition/creativity, emotional processing and personality

Solaja, I., Haldane, K., Mason, N. L., Weiss, B., Xu, X., Xu, M., Nikolin, S., Jayasena, T., Millard, M., Brett, J., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105570 · Cited by 20 · see citing works

fMRI Evidence for Default Mode Network Deactivation Associated with Rapid Eye Movements in Sleep

Hong, C. C.-H., Fallon, J., & Friston, K. J. (2021) · Brain Sciences · doi:10.3390/brainsci11111528 · Cited by 18 · see citing works

Meditating on psychedelics. A randomized placebo-controlled study of DMT and harmine in a mindfulness retreat

Meling, D., Egger, K., Aicher, H., Redondo, J. J., Mueller, J., Dornbierer, J., Temperli, E., Vasella, E. A., Caflisch, L., Pfeiffer, D., et al. (2024) · Journal of Psychopharmacology · doi:10.1177/02698811241282637 · Cited by 18 · see citing works

Psychosocial and Drug Use Assessment of Regular vs. Non-Regular Ayahuasca Users in a Brazilian Sample: a Web-Based Survey

Daldegan‐Bueno, D., Révész, D., Morais, P. R., Barbosa, P. C. R., & Maia, L. O. (2022) · Substance Use & Misuse · doi:10.1080/10826084.2022.2063896 · Cited by 17 · see citing works

Therapeutic Potential Ascribed to Ayahuasca by Users in the Czech Republic

Horák, M., Hasíková, L., & Verter, N. (2018) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2018.1511878 · Cited by 17 · see citing works

Ayahuasca: what mental health professionals need to know

SANTOS, R. G. D., Bouso, J. C., & Hallak, J. E. C. (2017) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/0101-60830000000130 · Cited by 16 · see citing works

Sub-acute and long-term effects of ayahuasca on mental health and well-being in healthy ceremony attendants: A replication study

van Oorsouw, K. I. M., Uthaug, M. V., Mason, N. L., Broers, N. J., & Ramaekers, J. G. (2021) · Journal of Psychedelic Studies · doi:10.1556/2054.2021.00174 · Cited by 16 · see citing works

Altered State of Consciousness and Mental Imagery as a Function of N, N-dimethyltryptamine Concentration in Ritualistic Ayahuasca Users

Ramaekers, J. G., Mallaroni, P., Kloft, L., Reckweg, J. T., Toennes, S. W., van Oorsouw, K. I. M., & Mason, N. L. (2023) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_02003 · Cited by 15 · see citing works

Effect of Ritualistic Consumption of Ayahuasca on Hepatic Function in Chronic Users

Mello, S. M., Soubhia, P. C., Silveira, G. D. O., Correa-Netto, N. F., Lanaro, R., Costa, J. L., & Linardi, A. (2018) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2018.1557355 · Cited by 15 · see citing works

Ayahuasca-induced personal death experiences: prevalence, characteristics, and impact on attitudes toward death, life, and the environment

David, J., Bouso, J. C., Kohek, M., Oña, G., Tadmor, N., Arnon, T., Dor‐Ziderman, Y., & Berkovich‐Ohana, A. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1287961 · Cited by 12 · see citing works

Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users

Fonseca, A. M., SANTOS, R. G. D., de Medeiros, L. S., Veiga, T. A. M., Cassas, F., Bruniera, C. P., Rossi, G. N., Bouso, J. C., Hallak, J. E. C., Santos, F. P., et al. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01817-9 · Cited by 13 · see citing works

Ayahuasca and Childhood Trauma: Potential Therapeutic Applications

Perkins, D., & Sarris, J. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-55688-4_6 · Cited by 13 · see citing works

Ayahuasca and its major component harmine promote antinociceptive effects in mouse models of acute and chronic pain

Lauria, P. S. S., Gomes, J. D. M., Abreu, L. S., Santana, R. C., Nunes, V. L. C., Couto, R. D., Colavolpe, P. O., da Silva, M. S., Soares, M. B. P., & Villarreal, C. F. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117710 · Cited by 12 · see citing works

Ayahuasca as a Decoction Applied to Human: Analytical Methods, Pharmacology and Potential Toxic Effects

Nižňanský, Ľ., Nižnanská, Ž., Kuruc, R., Szórádová, A., Šikuta, J., & Zummerová, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11041147 · Cited by 12 · see citing works

Psychosis induced by abuse of ayahuasca: a case report

Palma-Álvarez, R. F., Grau‐López, L., Ros‐Cucurull, E., Abad, A. C., Dualde, J., Robles-Martínez, M., & Roncero, C. (2020) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2019.10.005 · Cited by 12 · see citing works

Ayahuasca-induced psychosis: A case report

Tapia, H. R. C., Guzmán, M. A. G., & Ortiz, S. A. C. (2022) · Revista Colombiana de Psiquiatría (English ed ) · doi:10.1016/j.rcpeng.2022.08.008 · Cited by 12 · see citing works

Polypharmacology or “Pharmacological Promiscuity” In Psychedelic Research: What Are We Missing?

Oña, G., SANTOS, R. G. D., Hallak, J. E. C., & Bouso, J. C. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00614 · Cited by 12 · see citing works

Psicosis inducida por ayahuasca: reporte de un caso.

Neyra-Ontaneda, D. (2017) · Revista de Neuro-Psiquiatría · doi:10.20453/rnp.v80i4.3241 · Cited by 11 · see citing works

Should Australian Psychology Consider Enhancing Psychotherapeutic Interventions with Psychedelic Drugs? A Call for Research

Bright, S., & Williams, M. L. (2018) · Australian psychologist · doi:10.1111/ap.12345 · Cited by 10 · see citing works

Ayahuasca in the Czech Republic: Extended Version

Horák, M., & Verter, N. (2019) · doi:10.11118/978-80-7509-657-9 · Cited by 10 · see citing works

Harmaline potentiates morphine-induced antinociception via affecting the ventral hippocampal GABA-A receptors in mice

Alijanpour, S., Jafaripour, S., Ghasemzadeh, Z., Khakpai, F., & Zarrindast, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173806 · Cited by 9 · see citing works

The Pharmacology and Clinical Applications of Psychedelic Medicines Within Midwifery Practice

Stein, C. A., Penn, A., Hope, S., Dorsen, C. G., & Mangini, M. (2022) · Journal of Midwifery & Women s Health · doi:10.1111/jmwh.13371 · Cited by 8 · see citing works

Episodios psicóticos inducidos por ayahuasca: revisión sistemática a partir de un caso.

Alcantarilla, L., García-Alcarria, E., & Almonacid, C. (2022) · Revista de Neuro-Psiquiatría · doi:10.20453/rnp.v85i3.4331 · Cited by 7 · see citing works

Associations Between Ayahuasca Use in Naturalistic Settings and Mental Health and Wellbeing Outcomes: Analysis of a Large Global Dataset

Perkins, D., Sarris, J. J., Cowley‐Court, T., Aicher, H., Tófoli, L. F., Bouso, J. C., Opaleye, E. S., Halman, A., Coelho, N. L. G., & Schubert, V. (2024) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2024.2424288 · Cited by 7 · see citing works

Ayahuasca ceremony leaders’ perspectives on special considerations for eating disorders

Williams, M., Miller, A. K., & Lafrance, A. (2023) · Eating Disorders · doi:10.1080/10640266.2023.2271201 · Cited by 7 · see citing works

Treatment and outcomes at Takiwasi Center, a Peruvian therapeutic community: identifying patient-related indicators

Defelippe, V. M., Schlütter, A., Meriaan, A., Winkens, B., Kavenská, V., Rojas, G. S., & Politi, M. (2019) · Therapeutic Communities The International Journal of Therapeutic Communities · doi:10.1108/tc-07-2018-0016 · Cited by 7 · see citing works

Anxiety, panic, and hopelessness during and after ritual ayahuasca intake in a woman with generalized anxiety disorder: A case report

SANTOS, R. G. D., Osório, F. D. L., Crippa, J. A. S., & Hallak, J. E. C. (2017) · Journal of Psychedelic Studies · doi:10.1556/2054.01.2017.004 · Cited by 7 · see citing works

Psychedelics and Hallucinogens in Psychiatry: Finding New Pharmacological Targets

de Sousa, T. R., Rema, J., Machado, S. E. D. C., & Novais, F. (2021) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026621666211201145800 · Cited by 7 · see citing works

Psicosis por consumo de ayahuasca: un reporte de caso

Tapia, H. R. C., Guzmán, M. A. G., & Ortiz, S. A. C. (2021) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2020.11.014 · Cited by 6 · see citing works

Neural Network Modulation of Ayahuasca: A Systematic Review of Human Studies

Santos, G. H. D. M., Rodrigues, L. S., Rocha, J. M., Rossi, G. N., Oña, G., Bouso, J. C., Hallak, J. E. C., & SANTOS, R. G. D. (2023) · Psychoactives · doi:10.3390/psychoactives2010006 · Cited by 7 · see citing works

Ayahuasca Ethno-tourism and its Impact on the Indigenous Shuar Community (Ecuador) and Western Participants

Salibová, D. (2020) · Český lid · doi:10.21104/cl.2020.4.05 · Cited by 6 · see citing works

AYAHUASCA V ČESKÉ REPUBLICE

Horák, M. (2017) · Mendelova univerzita v Brně eBooks · doi:10.11118/978-80-7509-510-7 · Cited by 6 · see citing works

Subjective Effects of a Single Dose of Ayahuasca among College Students with Harmful Alcohol Use: Qualitative Analysis of Participant Accounts

Vicentini, A. B., Rodrigues, L. S., Rossi, G. N., Rocha, J. M., Guerra, L. T. L., Reis, J. A. S., Maekawa, R. M., Osório, F. D. L., Bouso, J. C., Santos, F. P., et al. (2023) · Psychoactives · doi:10.3390/psychoactives2040022 · Cited by 4 · see citing works

Treatment and therapy of mental health conditions in the Global South using psychedelics: A scoping review and narrative synthesis

Griffin, C., & Knight, A. (2024) · Journal of Psychedelic Studies · doi:10.1556/2054.2024.00333 · Cited by 4 · see citing works

A prospective ecological momentary assessment study of an ayahuasca retreat: exploring the salutary impact of acute psychedelic experiences on subacute affect and mindfulness skills in daily life

Sznitman, S. R., Behar, Y. A., Dicker‐Oren, S. D., Shochat, T., Meiri, D., Butto, N., Roe, D., & Bernstein, A. (2025) · Psychopharmacology · doi:10.1007/s00213-024-06704-8 · Cited by 4 · see citing works

The Novelty of Ayahuasca Scale and the prediction of intentions to use

Altman, B. R., Mian, M. N., & Earleywine, M. (2020) · Journal of Psychedelic Studies · doi:10.1556/2054.2020.00117 · Cited by 4 · see citing works

Potential Anti-Depressive Treatment Maneuvers from Bench to Bedside

Cai, M., Wang, H., & Zhang, X. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_15 · Cited by 4 · see citing works

The current state of ayahuasca research in animal models: A systematic reviewPreprint

Daldegan‐Bueno, D., Simionato, N. M., Favaro, V. M., & Maia, L. O. (2022) · doi:10.31234/osf.io/7s3b8 · Cited by 4 · see citing works

How to set up a psychedelic study: Unique considerations for research involving human participants

Glennon, M. J., Bird, C., Yadav, P., Kleine, P., Suseelan, S., Boman-Markaki, C., Kotoula, V., Butler, M., Leech, R., Roseman, L., et al. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106657 · Cited by 5 · see citing works

Beyond prohibition: A public health analysis of naturalistic psychedelic use

Haden, M., Paschall, S. A., & Woods, B. (2025) · Journal of Psychedelic Studies · doi:10.1556/2054.2025.00450 · Cited by 3 · see citing works

Psychosis induced by abuse of ayahuasca: a case report

Palma-Álvarez, R. F., Grau‐López, L., Ros‐Cucurull, E., Abad, A. C., Dualde, J., Robles-Martínez, M., & Roncero, C. (2021) · Revista Colombiana de Psiquiatría (English ed ) · doi:10.1016/j.rcpeng.2019.10.003 · Cited by 3 · see citing works

Ayahuasca – Religion, Life-style oder Droge?

Neu, P. (2020) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-1149-9187 · Cited by 2 · see citing works

Assessment of environmental condition and drying process of the plants on the concentration of alkaloids and cytotoxicity of traditional Ayahuasca Tea

de, M. O. F., de, A. M., de Oliveira, S. I. M., Ruiz, A. L. T. G., da, C. J. L., da Silva, M. R., & Foglio, M. A. (2021) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2021.10.2.0209 · Cited by 2 · see citing works

Could Psychedelics Treat Neuropathic Chronic Pain?

(2023) · Neurological Sciences and Neurosurgery · doi:10.47275/2692-093x-130 · Cited by 1 · see citing works

Ayahuasca enhances functional connectivity in the third visual pathway and mirror neuron networks: a crossover, multiple-dose functional MRI study

Soares, C., Lima, G., Teixeira, M., André, R., Rijo, P. M., Cabral, C., & Castelo-Branco, M. S. (2026) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsag004 · Cited by 1 · see citing works

The DEA report on ayahuasca risks: “Science” in service of prohibition?

Labate, B. C., Ermakova, A. O., Sloshower, J., Coelho, N. L. G., Palhano-Fontes, F., Antunes, H. F., de Assis, G. L., Cavnar, C., de Araújo, D. B., & Ribeiro, S. T. G. (2023) · Journal of Psychedelic Studies · doi:10.1556/2054.2023.00279 · Cited by 1 · see citing works

Special Subsection Afterword: ESP Research and Cognitive Neuroscience: Possibly Incompatible - But Methodologically Complementary

Acunzo, D. J. (2023) · Journal of Scientific Exploration · doi:10.31275/20233195 · Cited by 1 · see citing works

Ayahuasca and personality. A systematic review and meta-analysis of cross-sectional studies with long-term participants ( Ayahuasca y personalidad. Revisión sistemática y metaanálisis de estudios transversales con participantes de larga trayectoria )

Apud, I. (2023) · Studies in Psychology Estudios de Psicología · doi:10.1080/02109395.2022.2163776 · Cited by 1 · see citing works

Psychotherapeutic and neurobiological processes associated with ayahuasca’s mental health and wellbeing outcomes: a proposed model and implications for therapeutic usePreprint

Perkins, D., Ruffell, S., Day, K., Pinzon, D., & Sarris, J. J. (2022) · doi:10.31219/osf.io/e5tjc · Cited by 1 · see citing works

The Felt Presence experience: From cognition to the clinicPreprint

Barnby, J. M., Park, S., Baxter, T., Rosen, C., Brugger, P., & Alderson‐Day, B. (2022) · doi:10.31234/osf.io/qykhd · Cited by 1 · see citing works

Possible Therapeutics Effects of Ayahuasca, a Psychedelic Compound

Silva, L., & Bravo, L. (2022) · European Psychiatry · doi:10.1192/j.eurpsy.2022.2260

Preliminary effects of ayahuasca on mental and physical health: A systematic review of prospective studies

Haupt, M. J., Carra, S., Boehnke, K. F., & Aday, J. S. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111634 · Cited by 2 · see citing works

How does ayahuasca work from a psychiatric perspective? Pros and cons of the entheogenic therapy

Orsolini, L., Chiappini, S., Papanti, D., Latini, R., Volpe, U., Fornaro, M., Tomasetti, C., Vellante, F., & Berardis, D. D. (2020) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2728 · Cited by 28 · see citing works

Ayahuasca and the traveller: A scoping review of risks and possible benefits

Houle, S. K. D., Evans, D., Carter, C. A., & Schlagenhauf, P. (2021) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2021.102206 · Cited by 20 · see citing works

Ayahuasca: Pharmacology, Safety, and Therapeutic Effects

SANTOS, R. G. D., & Hallak, J. E. C. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009585330.005 · Cited by 18 · see citing works