Baroreflex mechanisms in irritable bowel syndrome: Part I. Traditional indices

Davydov, Dmitry M.; Naliboff, Bruce; Shahabi, Leila; Shapiro, David

doi:10.1016/j.physbeh.2016.01.042

Cited by 29Gastrointestinal motility and disordersHeart Rate Variability and Autonomic ControlCardiovascular Syncope and Autonomic Disorders

Baroreflex mechanisms in irritable bowel syndrome: Part I. Traditional indices

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Davydov, Dmitry M., Naliboff, Bruce, Shahabi, Leila, Shapiro, David·2016·Physiology & Behavior

DOI 10.1016/j.physbeh.2016.01.042PMC PMC4783246

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Abstract

Objective This study was conducted to present evidence of differences in autonomic regulation of cardiovascular activity and its role in the severity of specific (disease-related) and non-specific (negative affect and chronic pain-related) symptoms in individuals with Irritable Bowel Syndrome (IBS).Methods Seventy-eight female patients with IBS and 27 healthy women age 18-62 years were assessed for IBS symptoms, negative affect, and baroreceptor sensitivity (BRS), blood pressure (BP), heart rate, and heart rate variability (HRV) at rest. Direct and indirect regression effects were examined with application of the bootstrap procedure to validate findings.Results IBS was reliably related to lower resting BRS, higher BP, and higher negative affect compared to healthy controls. Longer disease duration (chronicity) was related to BRS decrease coupled with systolic BP increase (95% CIs=-0.14 to -0.01). Three autonomic mechanisms associated with BRS decrease were found to further regulate severity of IBS symptoms. Lower BRS was related to higher IBS severity in general if the effect was transferred through the decrease of low frequency power of HRV (e.g., 95% CIs=-0.039 to -0.001 for abdominal pain severity). However, lower BRS was related to lower IBS severity in general if the effect was transferred through diastolic BP increase (95% CIs=0.01-0.11 for abdominal pain severity). Lower BRS was related to higher abdominal pain severity coupled with high negative affect if the effect was transferred through the decrease of higher frequency power of HRV (95% CIs=-0.026 to -0.003).Conclusions These findings indicate that different cardiovascular mechanisms are associated with IBS development and the increase and decrease of severity of IBS symptoms. Their assessment suggests ways to personalize treatment of IBS.

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Viscerosensory-cardiovascular reflexes: altered baroreflex sensitivity in irritable bowel syndrome
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Authors: Davydov, D. M., Naliboff, B., Shahabi, L., & Shapiro, D.
Affiliations: Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
University of California, Los Angeles (US)
Corresponding author: Davydov, Dmitry M.
ORCID: Davydov, Dmitry M.
Naliboff, Bruce
Shapiro, David
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 2016-04
Volume: 157
Pages: 102-108
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/j.physbeh.2016.01.042
PMC: PMC4783246
OpenAlex: W2266813561
Cited by: 29
References: 62
Citations by year: 2025: 4 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2
FWCI: 2.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (R21 AT003221, R24 AT002681)
Gail and Gerald Oppenheimer Family Foundation
Russian Ministry of Science and Education (2934)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Keywords: irritable bowel syndrome, baroreflex sensitivity, autonomic regulation, heart rate variability, blood pressure, negative affect, abdominal pain, IBS symptom severity, disease duration, cardiovascular mechanisms, personalized treatment
MeSH terms: Adolescent, Adult, Blood Pressure, Electrocardiography, Female, Heart Rate, Humans, Middle Aged, Psychiatric Status Rating Scales, Severity of Illness Index, Statistics as Topic, Baroreflex, Mood Disorders, Irritable Bowel Syndrome, Young Adult

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