Cited by 624Pharmacology and Obesity TreatmentBioactive natural compoundsMedicinal Plant Research

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Possible anti-obesity therapeutics from nature--a review

Yun, Jong Won·2010·Phytochemistry

DOI 10.1016/j.phytochem.2010.07.011

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Abstract

Obesity is associated with many diseases, particularly diabetes, hypertension, osteoarthritis, and heart disease. The obesity incidence has increased at an alarming rate in recent years, becoming a worldwide health problem, with incalculable social costs. Two different obesity-treatment drugs are currently on the market: orlistat, which reduces intestinal fat absorption via inhibiting pancreatic lipase; and sibutramine, an anorectic or appetite suppressant. Both drugs have hazardous side-effects, including increased blood pressure, dry mouth, constipation, headache, and insomnia. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. These are mainly complex products having several components with different chemical and pharmacological features. This review aimed to survey the literature covering natural products with anti-obesity activity and to review the scientific data, including experimental methodologies, active components, and mechanisms of action against obesity.

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Authors: Yun, J. W.
Affiliations: Daegu University (KR)
Corresponding author: Yun, Jong Won
ORCID: Yun, Jong Won
Venue: Phytochemistry
Publisher: Elsevier BV
Published: 2010-10
Volume: 71
Issue: 14-15
Pages: 1625-1641
ISSN: 0031-9422 (ISSN-L)
DOI: 10.1016/j.phytochem.2010.07.011
OpenAlex: W2167277714
Cited by: 619
References: 294
Citations by year: 2026: 7 · 2025: 21 · 2024: 25 · 2023: 29 · 2022: 50 · 2021: 40 · 2020: 37 · 2019: 55 · 2018: 57 · 2017: 49 · 2016: 64 · 2015: 50 · 2014: 47 · 2013: 37 · 2012: 36
FWCI: 3.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Phytochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: obesity, anti-obesity drugs, natural products, orlistat, sibutramine, pancreatic lipase inhibition, appetite suppressants, mechanism of action, obesity-related comorbidities
MeSH terms: Appetite Depressants, Biological Products, Energy Metabolism, Lipase, Obesity, Plants, Medicinal, Adipocytes, Anti-Obesity Agents, Lipid Metabolism

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