The DOI matches its Crossref record; 294 of the 294 references it cites were found in a registry or an index.
Possible anti-obesity therapeutics from nature--a review
Abstract
Obesity is associated with many diseases, particularly diabetes, hypertension, osteoarthritis, and heart disease. The obesity incidence has increased at an alarming rate in recent years, becoming a worldwide health problem, with incalculable social costs. Two different obesity-treatment drugs are currently on the market: orlistat, which reduces intestinal fat absorption via inhibiting pancreatic lipase; and sibutramine, an anorectic or appetite suppressant. Both drugs have hazardous side-effects, including increased blood pressure, dry mouth, constipation, headache, and insomnia. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. These are mainly complex products having several components with different chemical and pharmacological features. This review aimed to survey the literature covering natural products with anti-obesity activity and to review the scientific data, including experimental methodologies, active components, and mechanisms of action against obesity.
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“Previous reports have shown that lipase inhibitors can effectively reduce fat absorption to suppress weight gain in obese patients [13,18].”
From Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose (2019) · cites this paper as [13]
In the citing paper
“Therefore, inhibition of pancreatic lipase decreases the absorption of lipids, which can reduce obesity [11,12,13].”
From Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose (2019) · cites this paper as [13]
Citations
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Metadata
- Authors
- Yun, J. W.
- Affiliations
- Daegu University (KR)
- Corresponding author
- Yun, Jong Won
- ORCID
- Yun, Jong Won
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 71
- Issue
- 14-15
- Pages
- 1625-1641
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2167277714
- Cited by
- 619
- References
- 294
- Citations by year
- 2026: 7 · 2025: 21 · 2024: 25 · 2023: 29 · 2022: 50 · 2021: 40 · 2020: 37 · 2019: 55 · 2018: 57 · 2017: 49 · 2016: 64 · 2015: 50 · 2014: 47 · 2013: 37 · 2012: 36
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- obesity, anti-obesity drugs, natural products, orlistat, sibutramine, pancreatic lipase inhibition, appetite suppressants, mechanism of action, obesity-related comorbidities
- MeSH terms
- Appetite Depressants, Biological Products, Energy Metabolism, Lipase, Obesity, Plants, Medicinal, Adipocytes, Anti-Obesity Agents, Lipid Metabolism
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