Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States
Abstract
Berberine has been shown to have antidiabetic properties, although its mode of action is not known. Here, we have investigated the metabolic effects of berberine in two animal models of insulin resistance and in insulin-responsive cell lines. Berberine reduced body weight and caused a significant improvement in glucose tolerance without altering food intake in db/db mice. Similarly, berberine reduced body weight and plasma triglycerides and improved insulin action in high-fat–fed Wistar rats. Berberine downregulated the expression of genes involved in lipogenesis and upregulated those involved in energy expenditure in adipose tissue and muscle. Berberine treatment resulted in increased AMP-activated protein kinase (AMPK) activity in 3T3-L1 adipocytes and L6 myotubes, increased GLUT4 translocation in L6 cells in a phosphatidylinositol 3′ kinase–independent manner, and reduced lipid accumulation in 3T3-L1 adipocytes. These findings suggest that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Berberine acts as a SIRT1 or AMPK agonist to mimic energy restriction.
“For patients with T2DM, the main function of berberine is as a SIRT1 or AMPK agonist to mimic energy restriction [75–77] and to target on NF-κB [78] to improve insulin resistance and inflammation as well as to alleviate the activation of ox-LDL-induced macrophages [79].”
From The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials (2021) · cites this paper as [76]
Cites
1 retracted
Metformin monotherapy for type 2 diabetes mellitus
Sáenz, A., Fernandez-Esteban, I., Mataix, A. L., Segura, M. A., Figuls, M. R. I., & Moher, D. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002966.pub3 · Cited by 304 · see citing works
RetractedRole of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795 · see citing works
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,626 · see citing works
Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398 · see citing works
Transcriptional regulation of adipogenesis.Preprint
Rosen, E., Walkey, C., Puigserver, P., & Spiegelman, B. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 2,180 · see citing works
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630 · see citing works
Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1135 · Cited by 1,391 · see citing works
Molecular Regulation of Adipogenesis
Rosen, E. D., & Spiegelman, B. M. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.145 · Cited by 1,287 · see citing works
Antidiabetic plants and their active constituents
Marles, R. J., & Farnsworth, N. R. (1995) · Phytomedicine · doi:10.1016/s0944-7113(11)80059-0 · Cited by 1,105 · see citing works
Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ
Hu, E., Kim, J. B., Sarraf, P., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.274.5295.2100 · Cited by 1,051 · see citing works
Self-citationFryer, L. G. D., Patel, A. P., & Carling, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202489200 · Cited by 1,030 · see citing works
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.Preprint
Kim, J. B., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.9.1096 · Cited by 1,026 · see citing works
Self-citation5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.
Kurth-Kraczek, E. J., Hirshman, M. F., Goodyear, L. J., & Winder, W. W. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1667 · Cited by 715 · see citing works
Hawley, S. A., Gadalla, A. E., Olsen, G. S., & Hardie, D. G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2420 · Cited by 696 · see citing works
Nawrocki, A. R., Rajala, M. W., Tomás, E., Pajvani, U. B., Saha, A. K., Trumbauer, M. E., Pang, Z., Chen, A. S., Ruderman, N. B., Chen, H., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505311200 · Cited by 640 · see citing works
Carling, D., Zammit, V. A., & Hardie, D. G. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80292-2 · Cited by 599 · see citing works
Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR
Russell, R. R., Bergeron, R., Shulman, G. I., & Young, L. H. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h643 · Cited by 553 · see citing works
Adams, M., Reginato, M. J., Shao, D., Lazar, M. A., & Chatterjee, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.8.5128 · Cited by 549 · see citing works
Zang, M., Zuccollo, A., Hou, X., Nagata, D., Walsh, K. X., Herscovitz, H., Brecher, P. I., Ruderman, N. B., & Cohen, R. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408149200 · Cited by 450 · see citing works
Purification and characterization of the AMP‐activated protein kinase
Carling, D., Clarke, P. R., Zammit, V. A., & Hardie, D. G. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb15186.x · Cited by 418 · see citing works
Wright, H. M., Clish, C. B., Mikami, T., Hauser, S., Yanagi, K., Hiramatsu, R., Serhan, C. N., & Spiegelman, B. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1873 · Cited by 368 · see citing works
Ye, J., Doyle, P. J., Iglesias, M. A., Watson, D. G., Cooney, G. J., & Kraegen, E. W. (2001) · Diabetes · doi:10.2337/diabetes.50.2.411 · Cited by 343 · see citing works
Self-citationBerberine sulfate: antimicrobial activity, bioassay, and mode of action
Amin, A., Subbaiah, T. V., & Abbasi, K. M. (1969) · Canadian Journal of Microbiology · doi:10.1139/m69-190 · Cited by 299 · see citing works
Zhang, B., Berger, J. P., Zhou, G., Elbrecht, A., Biswas, S., White-Carrington, S., Szalkowski, D., & Moller, D. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31771 · Cited by 276 · see citing works
DAVIES, S. P., SIM, A. T. R., & HARDIE, D. G. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15293.x · Cited by 274 · see citing works
Govers, R., Coster, A. C. F., & James, D. E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.14.6456-6466.2004 · Cited by 250 · see citing works
Self-citationLeng, S.-H., Lu, F., & Xu, L. (2004) · PubMed · Cited by 237 · see citing works
Effects of berberine on glucose metabolism in vitro
Yin, J., Hu, R., Chen, M., Tang, J., Li, F., Yang, Y., & Chen, J. (2002) · Metabolism · doi:10.1053/meta.2002.34715 · Cited by 234 · see citing works
Camp, H. S., Tafuri, S. R., & Leff, T. (1999) · Endocrinology · doi:10.1210/endo.140.1.6457 · Cited by 233 · see citing works
Wang, H. X., & Ng, T. B. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00253-2 · Cited by 223 · see citing works
AMP-activated protein kinase: balancing the scales
Carling, D. (2004) · Biochimie · doi:10.1016/j.biochi.2004.10.017 · Cited by 201 · see citing works
Xi, X., Han, J., & Zhang, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102824200 · Cited by 182 · see citing works
Insulin Sensitizing and Insulinotropic Action of Berberine from Cortidis Rhizoma
Ko, B., Choi, S. B., Park, S. K., Jang, J. S., Kim, Y. E., & Park, S. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.1431 · Cited by 181 · see citing works
Phosphorylation of PPARs: from molecular characterization to physiological relevance
Diradourian, C., Girard, J. R., & Pégorier, J. P. (2004) · Biochimie · doi:10.1016/j.biochi.2004.11.010 · Cited by 179 · see citing works
Frevert, E. U., & Kahn, B. B. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.190 · Cited by 178 · see citing works
Effect of berberine on proliferation, cell cycle and apoptosis in HeLa and L1210 cells
Jantová, S., Čipák, L., Čerňáková, M., & Košťálová, D. (2003) · Journal of Pharmacy and Pharmacology · doi:10.1211/002235703322277186 · Cited by 177 · see citing works
AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins
Leff, T. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310224 · Cited by 161 · see citing works
Inhibition of chemical carcinogenesis by berberine in rats and mice
Anis, K. V., Rajeshkumar, N. V., & Kuttan, R. (2001) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357011775901 · Cited by 159 · see citing works
Ye, J., Iglesias, M. A., Watson, D. G., Ellis, B. A., Wood, L., Jensen, P. B., Sørensen, R. V., Larsen, P. J., Cooney, G. J., Wassermann, K., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00299.2002 · Cited by 146 · see citing works
Self-citationYe, J.-M., Dzamko, N. L., Cleasby, M. E., Hegarty, B. D., Furler, S. M., Cooney, G. J., & Kraegen, E. W. (2004) · Diabetologia · doi:10.1007/s00125-004-1436-1 · Cited by 137 · see citing works
Self-citationMitochondrial metabolism and type-2 diabetes: a specific target of metformin
Leverve, X. M., Guigas, B., Détaille, D., Batandier, C., Koceir, E.-A., Chauvin, C., Fontaine, E. M., & Wiernsperger, N. F. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(03)72792-x · Cited by 129 · see citing works
Shewan, A. M., Marsh, B. J., Melvin, D. R., et al. (2000) · Biochemical Journal · doi:10.1042/bj3500099 · Cited by 101 · see citing works
AMP-activated protein kinase and the metabolic syndrome
Fryer, L. G., & Carling, D. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330362 · Cited by 91 · see citing works
Huypens, P., Quartier, E., PIPELEERS, D. G., & de Casteele, M. V. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.06.016 · Cited by 86 · see citing works
Taylor, C. E., & Greenough, W. B. (1989) · Annual Review of Public Health · doi:10.1146/annurev.pu.10.050189.001253 · Cited by 71 · see citing works
Ni, Y. X. (1988) · PubMed · Cited by 70 · see citing works
Lee, Y. S. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg934 · Cited by 62 · see citing works
Self-citation[Studies on the hypoglycemic effect of Coptis chinensis and berberine].
Qm, C., & Mz, X. (1986) · PubMed · Cited by 57 · see citing works
Obesity research springs a proton leak
Flier, J. S., & Lowell, B. B. (1997) · Nature Genetics · doi:10.1038/ng0397-223 · Cited by 53 · see citing works
Oral pharmacologic management of type 2 diabetes.
Riddle, M. (1999) · PubMed · Cited by 51 · see citing works
[Effect of berberine on the differentiation of adipocyte].
Lb, Z., Chen, M.-D., Wang, X., et al. (2003) · PubMed · Cited by 26 · see citing works
PPARγ and the thiazolidinediones: molecular basis for a treatment of ‘Syndrome X’?
Sewter, C. P., & Vidal‐Puig, A. (2002) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2002.00187.x · Cited by 22 · see citing works
What's in a risk factor? “He who strikes the ball”
Capron, L. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70001-0 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602 · see citing works
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638 · see citing works
Metabolism of Inflammation Limited by AMPK and Pseudo-Starvation
O'Neill, L. A. J., & Hardie, D. G. (2013) · Nature · doi:10.1038/nature11862 · Cited by 1,133 · see citing works
AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
Hardie, D. G., Schaffer, B. E., & Brunet, A. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.013 · Cited by 859 · see citing works
AMPK activators: mechanisms of action and physiological activities
Kim, J., Yang, G., Kim, Y., Kim, J., & Ha, J. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.16 · Cited by 817 · see citing works
Self-citationEfficacy of berberine in patients with type 2 diabetes mellitus
Yin, J., Xing, H., & Ye, J. (2008) · Metabolism · doi:10.1016/j.metabol.2008.01.013 · Cited by 801 · see citing works
Self-citationUse of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.001 · Cited by 773 · see citing works
Zhang, X., Zhao, Y., Xu, J., Xue, Z., Zhang, M., Pang, X., Zhang, X., & Zhao, L. (2015) · Scientific Reports · doi:10.1038/srep14405 · Cited by 630 · see citing works
Possible anti-obesity therapeutics from nature--a review
Yun, J. W. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.07.011 · Cited by 619 · see citing works
Zhang, X., Zhao, Y., Zhang, M., Pang, X., Xu, J., Kang, C., Li, M., Zhang, C., Zhang, Z., Zhang, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042529 · Cited by 615 · see citing works
Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine
Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2404 · Cited by 573 · see citing works
Turner, N., Li, J.-Y., Gosby, A., To, S. W. C., Cheng, Z., Miyoshi, H., Taketo, M. M., Cooney, G. J., Kraegen, E. W., James, D. E., et al. (2008) · Diabetes · doi:10.2337/db07-1552 · Cited by 535 · see citing works
Self-citationBerberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465 · see citing works
Sensing of energy and nutrients by AMP-activated protein kinase
Hardie, D. G. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.001925 · Cited by 372 · see citing works
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.
O’Neill, H. M., Holloway, G. P., & Steinberg, G. R. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.019 · Cited by 364 · see citing works
Wang, Y., Tong, Q., Ma, S.-R., Zhao, Z.-X., Pan, L.-B., Cong, L., Han, P., Peng, R., Yu, H., Lin, Y., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00456-5 · Cited by 319 · see citing works
Hepatic lipid metabolism and non-alcoholic fatty liver disease
Tessari, P., Coracina, A., Cosma, A., & Tiengo, A. (2009) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.12.015 · Cited by 314 · see citing works
Transforming berberine into its intestine-absorbable form by the gut microbiota
Feng, R., Shou, J.-W., Zhao, Z.-X., He, C.-Y., Ma, C., Huang, M., Fu, J., Tan, X.-S., Li, X.-Y., Wen, B.-Y., et al. (2015) · Scientific Reports · doi:10.1038/srep12155 · Cited by 307 · see citing works
Grahame Hardie, D. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12268 · Cited by 285 · see citing works
AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels
Hardie, D. G. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161148 · Cited by 281 · see citing works
Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats
Tan, X.-S., Ma, J.-Y., Feng, R., Ma, C., Chen, W.-J., Sun, Y.-P., Fu, J., Huang, M., He, C.-Y., Shou, J.-W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077969 · Cited by 266 · see citing works
Eid, H. M., Martineau, L. C., Saleem, A., Muhammad, A., Vallerand, D., Benhaddou-Andaloussi, A., Nistor, L., Afshar, A., Arnason, J. T., & Haddad, P. S. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900218 · Cited by 218 · see citing works
Gomes, A. P., Duarte, F. V., Nunes, P., Hubbard, B. P., Teodoro, J. S., Varela, A. T., Jones, J. G., Sinclair, D. A., Palmeira, C. M., & Rolo, A. P. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.008 · Cited by 159 · see citing works
Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., & Guan, Y. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0616 · Cited by 155 · see citing works
Gut Microbiota-Mediated Personalized Treatment of Hyperlipidemia Using Berberine
Wang, Y., Tong, Q., Shou, J.-W., Zhao, Z.-X., Li, X.-Y., Zhang, X.-F., Ma, S.-R., He, C.-Y., Lin, Y., Wen, B.-Y., et al. (2017) · Theranostics · doi:10.7150/thno.18290 · Cited by 131 · see citing works
Xu, Y., Yu, T., Ma, G., Zheng, L., Jiang, X., Yang, F., Wang, Z., Li, N., He, Z., Song, X., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.62556 · Cited by 110 · see citing works
Guo, J., Chen, H., Zhang, X., Lou, W., Zhang, P., Qiu, Y., Zhang, C., Wang, Y., & Liu, W. J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/2074610 · Cited by 110 · see citing works
Ye, Y., Liu, X., Wu, N., Han, Y., Wang, J., Yu, Y., & Chen, Q. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.653887 · Cited by 109 · see citing works
Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes
Li, Y., Ren, G., Wang, Y.-X., Kong, W.-J., Yang, P., Wang, Y.-M., Li, Y.-H., Yi, H., Li, Z.-R., Song, D.-Q., et al. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-62 · Cited by 109 · see citing works
The use of berberine for women with polycystic ovary syndrome undergoing <scp>IVF</scp> treatment
An, Y., Sun, Z., Zhang, Y., Liu, B., Guan, Y., & Lu, M. (2014) · Clinical Endocrinology · doi:10.1111/cen.12294 · Cited by 105 · see citing works
Meng, S., Wang, L., Huang, Z., Zhou, Q., Sun, Y., Cao, J., Li, Y., & Wang, C. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2012.05670.x · Cited by 99 · see citing works
RETRACTED: Redox Regulation of the AMP-Activated Protein Kinase
Han, Y., Wang, Q., Song, P., Zhu, Y., & Zou, M.-H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015420 · Cited by 71 · see citing works
RetractedNutraceutical Activation of Sirt1: A Review
DiNicolantonio, J. J., McCarty, M. F., & O'Keefe, J. H. (2022) · Open Heart · doi:10.1136/openhrt-2022-002171 · Cited by 65 · see citing works
Di, S., Han, L., An, X., Kong, R., Gao, Z., Yang, Y., Wang, X., Zhang, P., Ding, Q., Wu, H., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114180 · Cited by 57 · see citing works
Zhu, M. J., Du, M., Nijland, M. J., Nathanielsz, P. W., Hess, B. W., Moss, G. E., & Ford, S. P. (2009) · Placenta · doi:10.1016/j.placenta.2009.02.001 · Cited by 54 · see citing works
Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment
Han, Y., Xiang, Y., Shi, Y., Tang, X., Pan, L., Gao, J., Bi, R., & Lai, X. (2021) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2021/9987097 · Cited by 51 · see citing works
Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine
Shan, Y., Zhang, S., Gao, B., Liang, S., Zhang, H., Yu, X., Zhao, J., Ye, L., Yang, Q., & Shang, W. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.591227 · Cited by 49 · see citing works
Yadav, A., Singh, A., Phogat, J., Dahuja, A., & Dabur, R. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113510 · Cited by 49 · see citing works
Mitochondrial Inhibitor as a New Class of Insulin Sensitizer
Zhang, Y., & Ye, J. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.010 · Cited by 47 · see citing works
Solnier, J., Zhang, Y., Kuo, Y., Du, M., Roh, K., Gahler, R., Wood, S., & Chang, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112567 · Cited by 47 · see citing works
Ma, H., He, K., Zhu, J., Li, X., & Ye, X. (2019) · Fitoterapia · doi:10.1016/j.fitote.2019.03.003 · Cited by 37 · see citing works
Reddi, K., Li, H., Li, W., & Tetali, S. (2021) · Molecules · doi:10.3390/molecules26164733 · Cited by 35 · see citing works
Shi, R., Xu, Z., Xu, X., Jin, J., Zhao, Y., Wang, T., Li, Y., & Ma, Y. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.11.010 · Cited by 25 · see citing works
Cole, L. K., Zhang, M., Chen, L., Sparagna, G. C., Vandel, M., Xiang, B., Dolinsky, V. W., & Hatch, G. M. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxaa408 · Cited by 18 · see citing works
Shi, R., Yang, Y., Xu, Z., Dai, Y., Zheng, M., Wang, T., Li, Y., & Ma, Y. (2018) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2112 · Cited by 14 · see citing works
Dumitru, C. N., Marcu, T., Dumitru, A. O., Tudor, S. S., Ferțu, I. D., Elisei, A.-M., & Goroftei, L. (2026) · Pharmaceuticals · doi:10.3390/ph19081313 · Cited by 2 · see citing works
- Authors
- Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Ye, J.-M., Lee, C. H., Oh, W. K., Kim, C. T., Hohnen-Behrens, C., Gosby, A., Kraegen, E. W., James, D. E., & Kim, J. B.
- Affiliations
- Seoul National University (KR)
- Garvan Institute of Medical Research (AU)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-08-01
- Volume
- 55
- Issue
- 8
- Pages
- 2256-2264
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2117680364
- Cited by
- 1,054
- References
- 55
- Citations by year
- 2026: 33 · 2025: 35 · 2024: 30 · 2023: 45 · 2022: 59 · 2021: 65 · 2020: 73 · 2019: 62 · 2018: 59 · 2017: 77 · 2016: 62 · 2015: 57 · 2014: 67 · 2013: 66 · 2012: 51
- FWCI
- 20.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion)
- KRIBB Repository (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- berberine, AMPK, insulin resistance, obesity, glucose tolerance, lipogenesis, energy expenditure, GLUT4 translocation, adipocytes, myotubes, triglycerides, db/db mice, high-fat diet, antidiabetic natural products
- MeSH terms
- Adipose Tissue, Animals, Berberine, Cell Line, Diabetes Mellitus, Diet, Dietary Fats, Energy Metabolism, Enzyme Activation, Gene Expression Regulation, Insulin Resistance, Lipids, Liver, Male, Mice, Inbred C57BL, Mice, Obese, Multienzyme Complexes, Obesity, Phosphorylation, Glucose Clamp Technique, Weight Loss, Rats, Wistar, Protein Serine-Threonine Kinases, Adipocytes, Muscle, Skeletal, Muscle Fibers, Skeletal, Phosphatidylinositol 3-Kinases, 3T3-L1 Cells, Glucose Transporter Type 4, Mice, Rats, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review