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Cited by 131Pregnancy and preeclampsia studiesBirth, Development, and HealthNeonatal and fetal brain pathology

Development and Mechanisms of Fetal Hypoxia in Severe Fetal Growth Restriction

Regnault, T.R.H., de Vrijer, B., Galan, H.L., Wilkening, R.B., Battaglia, F.C., Meschia, G.·2007·Placenta
DOI 10.1016/j.placenta.2006.06.007
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Abstract

Severe fetal growth restriction (FGR) is often associated with hypoxia. We studied FGR hypoxia in an experimental model which is produced by exposing pregnant ewes to a hyperthermic environment. The study utilized simultaneous measurements of several relevant factors, e.g., uterine and umbilical blood flows and O(2) uptakes. Sixteen ewes were divided equally into control (C) and hyperthermic (HT) groups. Hyperthermia (40 degrees C for 12h/35 degrees C for 12h; approximately 35% relative humidity, RH) was maintained for 80 days commencing at approximately 38 days gestational age (dGA term 147+/-3 days). All ewes were then placed in a control environment ( approximately 21 degrees C, 24h; approximately 30% RH) and studied at approximately 134 dGA. Mean HT placental and fetal weights were 39% and 45% of C, respectively (p<0.0001), umbilical O(2) uptake/kg fetus was 76% of C (p<0.01) and umbilical venous PO(2) was reduced (20.2 vs. 29.7 Torr, p<0.001). Contrary to the hypothesis that FGR hypoxia is due to maternal placental hypoperfusion, uterine flow was not reduced in relation to O(2) uptake. The uterine-umbilical venous PO(2) difference was enlarged (38 vs. 23 Torr, p<0.0001). This difference is the expression of a balance between developmental changes in placental structure and oxidative metabolism, which have opposite effects in terms of fetal oxygenation. We postulate that FGR hypoxia results from disproportionate underdevelopment of those changes which allow for a progressive increase in umbilical O(2) uptake.

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  • Lactate production by ovine uteroplacental tissues is reduced by 24 h of placental-fetal hypoxemia induced by restricting uterine blood flow or placental growth by hyperthermia.

    “Certainly, lactate production by ovine uteroplacental tissues is reduced by 24 h of placental-fetal hypoxemia induced by restricting uterine blood flow or placental growth by hyperthermia (263, 456).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [456]

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Authors
Regnault, T. R. H., de Vrijer, B., Galan, H. L., Wilkening, R. B., Battaglia, F. C., & Meschia, G.
Affiliations
  • University of Colorado Health (US)
  • University of Colorado Denver (US)
Corresponding author
Regnault, T.R.H.
ORCID
Venue
Placenta
Publisher
Elsevier BV
Published
2007-07
Volume
28
Issue
7
Pages
714-723
ISSN
0143-4004 (ISSN-L)
DOI
10.1016/j.placenta.2006.06.007
OpenAlex
W2094104040
Cited by
131
References
52
Citations by year
2026: 4 · 2025: 10 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 13 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 12
FWCI
5.11
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Placenta (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL071990, HL071990-01A1)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 41505, R01HD041505, HD20761)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords
fetal growth restriction, fetal hypoxia, hyperthermia, maternal hyperthermia, placental hypoperfusion, uterine blood flow, fetal oxygenation, placental development, oxidative metabolism, fetal development, sheep model
MeSH terms
Animals, Blood Glucose, Body Temperature, Disease Models, Animal, Female, Fetal Hypoxia, Fetal Blood, Fetal Growth Retardation, Heating, Insulin, Maternal-Fetal Exchange, Organ Size, Oxygen, Partial Pressure, Pregnancy, Respiration, Sheep, Lactic Acid, Placental Circulation

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