Functional Evidence for Oxygen-Sensitive Voltage-Gated Potassium Channels in Human Placental Vasculature
Abstract
Hypoxic fetoplacental vasoconstriction (HFPV), involving voltage-gated potassium (K(V)) channels, has been suggested in human placenta; the identity of these channels remains unclear. Using wire myography, chorionic plate blood vessels were exposed to isoform-specific K(V) channel blockers. Dose-response curves (thromboxane mimetic U46619; 0.1-2000 nM) pre- and post-addition of K(V) channel modulator were analysed. Arterial U46619-induced contraction increased with margatoxin and stromatoxin-1, whilst only correolide increased U46619-induced contraction in veins (P < 0.05 two-way ANOVA). Basal tone was unaffected in arteries or veins. These data implicate K(V)1.2 and/or K(V)2.1 and K(V)1.5 in the control of agonist-induced contraction of human placental arteries and veins respectively.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A variety of K+ channel subtypes, many of them oxygen sensitive, are present in the vasculature of the human placenta.
“A variety of K + channel subtypes, many of them oxygen sensitive, are present in the vasculature of the human placenta (307, 563, 564).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [307]
Cites
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works
Wei, A. D., Gutman, G. A., Aldrich, R. W., Chandy, K. G., Grissmer, S., & Wulff, H. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.9 · Cited by 976 · see citing works
Gutman, G. A., Chandy, K. G., Grissmer, S., Lazdunski, M., McKinnon, D. H., Pardo, L. A., Robertson, G. A., Rudy, B., Sanguinetti, M. C., Stühmer, W., et al. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.10 · Cited by 888 · see citing works
Pozeg, Z., Michelakis, E. D., McMurtry, M. S., Thébaud, B., Wu, X., Dyck, J. R. B., Hashimoto, K., Wang, S., Moudgil, R., Harry, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000062688.76508.b3 · Cited by 260 · see citing works
Archer, S. L., Wu, X., Thébaud, B., Nsair, A., Bonnet, S., Tyrrell, B. D., McMurtry, M. S., Hashimoto, K., Harry, G., & Michelakis, E. D. (2004) · Circulation Research · doi:10.1161/01.res.0000137173.42723.fb · Cited by 192 · see citing works
Michelakis, E. D. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.09.007 · Cited by 165 · see citing works
Control of vascular resistance in the human placenta
Myatt, L. (1992) · Placenta · doi:10.1016/0143-4004(92)90057-z · Cited by 164 · see citing works
Oxygen Sensitivity of Cloned Voltage-Gated K+Channels Expressed in the Pulmonary Vasculature
Hulme, J. T., Coppock, E. A., Felipe, A., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.6.489 · Cited by 162 · see citing works
Control of vascular resistance in the maternal and feto-placental arterial beds
Poston, L., McCarthy, A. L., & Ritter, J. M. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)00064-a · Cited by 148 · see citing works
Archer, S. L., & Michelakis, E. D. (2002) · Physiology · doi:10.1152/nips.01388.2002 · Cited by 138 · see citing works
Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition
Hampl, V., Bı́bová, J., Straňák, Z., Wu, X., Michelakis, E. D., Hashimoto, K., & Archer, S. L. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01033.2001 · Cited by 104 · see citing works
Koo, G. C., Blake, J. T., Shah, K., Staruch, M. J., Dumont, F. J., Wunderler, D., Sánchez, M., McManus, O. B., Sirotina, A., Fischer, P. A., et al. (1999) · Cellular Immunology · doi:10.1006/cimm.1999.1569 · Cited by 81 · see citing works
Characterization of Small Arteries Isolated From the Human Placental Chorionic Plate
Wareing, M., Crocker, I. P., Warren, A. Y., Taggart, M. J., & Baker, P. N. (2002) · Placenta · doi:10.1053/plac.2002.0825 · Cited by 78 · see citing works
Self-citationExpression and function of potassium channels in the human placental vasculature
Wareing, M., Bai, X., Seghier, F., et al. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00040.2006 · Cited by 66 · see citing works
Self-citationWareing, M., Greenwood, S. L., & Baker, P. N. (2005) · Placenta · doi:10.1016/j.placenta.2004.11.008 · Cited by 40 · see citing works
Self-citationSand, A., Andersson, E., & Fried, G. M. (2005) · Placenta · doi:10.1016/j.placenta.2004.12.013 · Cited by 30 · see citing works
Corcoran, J. J., Lacey, H. A., Baker, P. N., & Wareing, M. (2008) · Hypertension in Pregnancy · doi:10.1080/10641950701826158 · Cited by 20 · see citing works
Self-citationMoreno, L., Frazziano, G., Cogolludo, A. L., et al. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.037002 · Cited by 18 · see citing works
Glibenclamide Inhibits Agonist-induced Vasoconstriction of Placental Chorionic Plate Arteries
Wareing, M., Greenwood, S. L., Fyfe, G. K., et al. (2005) · Placenta · doi:10.1016/j.placenta.2005.05.012 · Cited by 15 · see citing works
Self-citationHigh-throughput analysis of drug binding interactions for the human cardiac channel, Kv1.5
Karczewski, J., Kiss, L., Kane, S. A., et al. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.035 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Oxygen Sensitivity, Potassium Channels, and Regulation of Placental Vascular Tone
Wareing, M. (2014) · Microcirculation · doi:10.1111/micc.12069 · Cited by 30 · see citing works
Self-citationReview: Potassium channels in the human fetoplacental vasculature
Wareing, M., & Greenwood, S. L. (2011) · Placenta · doi:10.1016/j.placenta.2010.12.022 · Cited by 20 · see citing works
Self-citation
- Authors
- Kiernan, M. F., Barrie, A., Szkolar, J., Mills, T. A., & Wareing, M.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Wareing, M.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 31
- Issue
- 6
- Pages
- 553-555
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W2098714915
- Cited by
- 18
- References
- 20
- Citations by year
- 2024: 1 · 2022: 2 · 2018: 1 · 2016: 4 · 2015: 1 · 2013: 3 · 2012: 4
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- voltage-gated potassium channels, placental vasculature, margatoxin, wire myography
- MeSH terms
- Analysis of Variance, Arteries, Dose-Response Relationship, Drug, Female, Humans, Placenta, Pregnancy, Scorpion Venoms, Triterpenes, Vasoconstriction, Veins, 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid, Shaker Superfamily of Potassium Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
