Review: Potassium channels in the human fetoplacental vasculature
Abstract
Despite their fundamental importance for normal cellular function, potassium (K) channels have been poorly studied in placental vascular tissues. This lack of experimental focus may relate to the fact that, as yet, no pregnancy complications have been directly attributable to a specific "channelopathy". K channel activity is central to normal cellular function. Vascular smooth muscle and endothelial cells within the fetoplacental circulation would be expected to be heavily influenced by the behaviour of K channels, as has been well-documented in other vascular beds. In this review, we summarise current understanding of K channel expression and activity in fetoplacental vasculature in normal and complicated pregnancies.
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A variety of K+ channel subtypes, many of them oxygen sensitive, are present in the vasculature of the human placenta.
“A variety of K + channel subtypes, many of them oxygen sensitive, are present in the vasculature of the human placenta (307, 563, 564).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [564]
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Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Mistry, H. D., McCallum, L. A., Kurlak, L. O., Greenwood, I. A., Broughton Pipkin, F., & Tribe, R. M. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.173740 · Cited by 48 · see citing works
- Authors
- Wareing, M., & Greenwood, S. L.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Wareing, M.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 32
- Pages
- S203-S206
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W2145849863
- Cited by
- 20
- References
- 42
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2020: 2 · 2019: 2 · 2016: 2 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Funders
- British Heart Foundation
- Action Medical Research
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- potassium channels, fetoplacental circulation, placental vasculature, vascular smooth muscle, endothelial cells, pregnancy complications, channelopathies
- MeSH terms
- Endothelium, Vascular, Female, Humans, Muscle, Smooth, Vascular, Placenta, Pregnancy, Pregnancy Complications, Potassium Channels
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