Docosahexaenoic acid supplementation (DHA) and the return on investment for pregnancy outcomes
Open accessAbstract
The Kansas University DHA Outcomes Study (KUDOS) found a significant reduction in early preterm births with a supplement of 600mg DHA per day compared to placebo. The objective of this analysis was to determine if hospital costs differed between groups. We applied a post-hoc cost analysis of the delivery hospitalization and all hospitalizations in the following year to 197 mother-infant dyads who delivered at Kansas University Hospital. Hospital cost saving of DHA supplementation amounted to $1678 per infant. Even after adjusting for the estimated cost of providing 600mg/d DHA for 26 weeks ($166.48) and a slightly higher maternal care cost ($26) in the DHA group, the net saving per dyad was $1484. Extrapolating this to the nearly 4 million US deliveries per year suggests universal supplementation with 600mg/d during the last 2 trimesters of pregnancy could save the US health care system up to USD 6 billion.
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DHA supplementation during pregnancy was estimated to be both medically and socio-economically relevant through its ability to reduce the incidence of premature birth.
“DHA supplementation during pregnancy was estimated to be both medically and socio-economically relevant through its ability to reduce the incidence of premature birth [132].”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [132]
Shireman and colleagues demonstrated, after applying a post-hoc cost analysis of delivery hospitalizations and all hospitalizations in the year following deliveries at Kansas University Hospital, that hospital cost savings related to DHA supplementation were estimated to be USD 1,678 per infant.
“Shireman and colleagues [132] demonstrated, after applying a post-hoc cost analysis of delivery hospitalizations and all hospitalizations in the year following deliveries at the Kansas University Hospital, that hospital cost savings related to DHA supplementation were estimated to be USD 1,678 per infant.”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [132]
Even after adjusting for the estimated cost of providing 600 mg/day of supplemental DHA for 26 weeks (USD 166.48) and a slightly higher maternal care cost (USD 26) in the DHA group, the net saving per mother-child pair was USD 1,484.
“Even after adjusting for the estimated cost of providing 600 mg/day of supplemental DHA for 26 weeks (USD 166.48) and a slightly higher maternal care cost (USD 26) in the DHA group, the net saving per mother-child pair was USD 1,484.”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [132]
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The Cost of Preterm Birth Throughout Childhood in England and Wales
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DHA supplementation and pregnancy outcomes
Carlson, S. E., Colombo, J., Gajewski, B. J., Gustafson, K. M., Mundy, D., Yeast, J., Georgieff, M. K., Markley, L. A., Kerling, E. H., & Shaddy, D. J. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.050021 · Cited by 329 · see citing works
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Ahmed, S., Makrides, M., Sim, N., McPhee, A., Quinlivan, J. A., Gibson, R. A., & Umberger, W. J. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.08.002 · Cited by 13 · see citing works
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Research works printed but not linked: 1
- [2]B. Institute of Medicine Committee on Understanding Premature, O. Assuring Healthy, The National Academies Collection Behrman RE Butler AS Reports funded by National Institutes of Health Preterm Birth: Causes, Consequences, and Prevention 2007 National Academies Press (US) National Academy of Sciences. Washington (DC) 20669423
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Van Dael, P. (2021) · Nutrition Research and Practice · doi:10.4162/nrp.2021.15.2.137 · Cited by 138 · see citing works
- Authors
- Shireman, T. I., Kerling, E. H., Gajewski, B. J., Colombo, J., & Carlson, S. E.
- Affiliations
- University of Kansas Medical Center (US)
- University of Kansas (US)
- Corresponding author
- Carlson, S.E.
- Venue
- Prostaglandins, Leukotrienes and Essential Fatty Acids
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 111
- Pages
- 8-10
- ISSN
- 0952-3278 (ISSN-L)
- PMC
- PMC4978141
- OpenAlex
- W2379204335
- Cited by
- 15
- References
- 6
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2021: 2 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 2
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Prostaglandins Leukotrienes and Essential Fatty Acids (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD047315)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Keywords
- docosahexaenoic acid, omega-3 supplementation, pregnancy outcomes, preterm birth, hospital costs, cost reduction, healthcare cost analysis
- MeSH terms
- Docosahexaenoic Acids, Female, Hospitalization, Humans, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Cost Savings, Health Care Costs, Dietary Supplements, Maternal Nutritional Physiological Phenomena, Premature Birth
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