The DOI matches its Crossref record; 72 of the 74 references it cites were found in a registry or an index.
Regulation of HMG-CoA reductase in mammals and yeast
Open accessAbstract
HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of hypocholesterolemic drug therapy. HMGR activity is tightly regulated to ensure maintenance of lipid homeostasis, disruption of which is a major cause of human morbidity and mortality. HMGR regulation takes place at the levels of transcription, translation, post-translational modification and degradation. In this review, we discuss regulation of mammalian, Saccharomyces cerevisiae and Schizosaccharomyces pombe HMGR and highlight recent advances in the field. We find that the general features of HMGR regulation, including a requirement for the HMGR-binding protein Insig, are remarkably conserved between mammals and ascomycetous fungi, including S. cerevisiae and S. pombe. However the specific details by which this regulation occurs differ in surprising ways, revealing the broad evolutionary themes underlying both HMGR regulation and Insig function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A key checkpoint for ergosterol biosynthesis involves the synthesis of HMG-CoA, catalyzed by HMGR (reviewed in [62]).”
From Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae (2020) · cites this paper as [62]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Regulation of the mevalonate pathway
Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530417 · Cited by 1,927
Structural mechanism for statin inhibition of HMG-CoA reductase
Istvan, E. S., & Deisenhofer, J. (2001) · Science · doi:10.1126/science.1059344 · Cited by 1,644
Protein Sensors for Membrane Sterols
Goldstein, J. L., DeBose-Boyd, R. A., & Brown, M. S. (2006) · Cell · doi:10.1016/j.cell.2005.12.022 · Cited by 1,517
THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?
Hardie, D. G., Carling, D., & Carlson, M. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.821 · Cited by 1,440
Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360
Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232
Crucial Step in Cholesterol Homeostasis
Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L., & Brown, M. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00872-3 · Cited by 987
Self-citationML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.
Endo, A., KURODA, M., & Tsujita, Y. (1976) · The Journal of Antibiotics · doi:10.7164/antibiotics.29.1346 · Cited by 954
Flagged first, then by citations
2 of the 74 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis
Vranová, E., Coman, D., & Gruissem, W. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120116 · Cited by 1,168
Min, H., Kapoor, A., Fuchs, M. A., Mirshahi, F., Zhou, H., Maher, J. W., Kellum, J. M., Warnick, R., Contos, M. J., & Sanyal, A. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.004 · Cited by 668
Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae
Jordá, T., & Puig, S. (2020) · Genes · doi:10.3390/genes11070795 · Cited by 489
Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
Ke, R., Xu, Q., Li, C., Luo, L., & Huang, D. (2017) · Cell Biology International · doi:10.1002/cbin.10915 · Cited by 421
Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)
Sharpe, L. J., & Brown, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.479808 · Cited by 382
Metadata
- Authors
- Burg, J. S., & Espenshade, P. J.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Espenshade, Peter J.
- Venue
- Progress in Lipid Research
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 50
- Issue
- 4
- Pages
- 403-410
- ISSN
- 0163-7827 (ISSN-L)
- PMC
- PMC3184313
- OpenAlex
- W2086024248
- Cited by
- 303
- References
- 74
- Citations by year
- 2026: 19 · 2025: 24 · 2024: 22 · 2023: 19 · 2022: 24 · 2021: 23 · 2020: 30 · 2019: 25 · 2018: 18 · 2017: 16 · 2016: 15 · 2015: 12 · 2014: 13 · 2013: 23 · 2012: 19
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Lipid Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL077588, HL 077588)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079637)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- HMG-CoA reductase, Insig, sterol biosynthesis, isoprenoid biosynthesis, lipid homeostasis, transcriptional regulation, post-translational modification, protein degradation, cholesterol-lowering drugs, Saccharomyces cerevisiae, Schizosaccharomyces pombe, evolutionary conservation, membrane-bound enzyme
- MeSH terms
- Acyl Coenzyme A, Adenylate Kinase, Animals, Gene Expression Regulation, Humans, Hydroxymethylglutaryl CoA Reductases, Mammals, Membrane Proteins, Protein Binding, Protein Processing, Post-Translational, Saccharomyces cerevisiae, Schizosaccharomyces, Sterols, Signal Transduction, Intracellular Signaling Peptides and Proteins, Protein Phosphatase 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
