Cited by 303Cholesterol and Lipid MetabolismCancer, Lipids, and MetabolismLipid metabolism and biosynthesis

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Regulation of HMG-CoA reductase in mammals and yeast

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Burg, John S., Espenshade, Peter J.·2011·Progress in Lipid Research

DOI 10.1016/j.plipres.2011.07.002PMC PMC3184313

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Abstract

HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of hypocholesterolemic drug therapy. HMGR activity is tightly regulated to ensure maintenance of lipid homeostasis, disruption of which is a major cause of human morbidity and mortality. HMGR regulation takes place at the levels of transcription, translation, post-translational modification and degradation. In this review, we discuss regulation of mammalian, Saccharomyces cerevisiae and Schizosaccharomyces pombe HMGR and highlight recent advances in the field. We find that the general features of HMGR regulation, including a requirement for the HMGR-binding protein Insig, are remarkably conserved between mammals and ascomycetous fungi, including S. cerevisiae and S. pombe. However the specific details by which this regulation occurs differ in surprising ways, revealing the broad evolutionary themes underlying both HMGR regulation and Insig function.

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Authors: Burg, J. S., & Espenshade, P. J.
Affiliations: Johns Hopkins University (US)
Corresponding author: Espenshade, Peter J.
ORCID: Burg, John S.
Espenshade, Peter J.
Venue: Progress in Lipid Research
Publisher: Elsevier BV
Published: 2011-10
Volume: 50
Issue: 4
Pages: 403-410
ISSN: 0163-7827 (ISSN-L)
DOI: 10.1016/j.plipres.2011.07.002
PMC: PMC3184313
OpenAlex: W2086024248
Cited by: 303
References: 74
Citations by year: 2026: 19 · 2025: 24 · 2024: 22 · 2023: 19 · 2022: 24 · 2021: 23 · 2020: 30 · 2019: 25 · 2018: 18 · 2017: 16 · 2016: 15 · 2015: 12 · 2014: 13 · 2013: 23 · 2012: 19
FWCI: 3.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Lipid Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Heart Association
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL077588, HL 077588)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079637)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: HMG-CoA reductase, Insig, sterol biosynthesis, isoprenoid biosynthesis, lipid homeostasis, transcriptional regulation, post-translational modification, protein degradation, cholesterol-lowering drugs, Saccharomyces cerevisiae, Schizosaccharomyces pombe, evolutionary conservation, membrane-bound enzyme
MeSH terms: Acyl Coenzyme A, Adenylate Kinase, Animals, Gene Expression Regulation, Humans, Hydroxymethylglutaryl CoA Reductases, Mammals, Membrane Proteins, Protein Binding, Protein Processing, Post-Translational, Saccharomyces cerevisiae, Schizosaccharomyces, Sterols, Signal Transduction, Intracellular Signaling Peptides and Proteins, Protein Phosphatase 2

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Regulation of HMG-CoA reductase in mammals and yeast

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