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Cited by 216Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 323 of the 326 references it cites were found in a registry or an index.

Modulators in concert for cognition: Modulator interactions in the prefrontal cortex

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Briand, Lisa A., Gritton, Howard, Howe, William M., Young, Damon A., Sarter, Martin·2007·Progress in Neurobiology
DOI 10.1016/j.pneurobio.2007.06.007PMC PMC2080765
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Abstract

Research on the regulation and function of ascending noradrenergic, dopaminergic, serotonergic, and cholinergic systems has focused on the organization and function of individual systems. In contrast, evidence describing co-activation and interactions between multiple neuromodulatory systems has remained scarce. However, commonalities in the anatomical organization of these systems and overlapping evidence concerning the post-synaptic effects of neuromodulators strongly suggest that these systems are recruited in concert; they influence each other and simultaneously modulate their target circuits. Therefore, evidence on the regulatory and functional interactions between these systems is considered essential for revealing the role of neuromodulators. This postulate extends to contemporary neurobiological hypotheses of major neuropsychiatric disorders. These hypotheses have focused largely on aberrations in the integrity or regulation of individual ascending modulatory systems, with little regard for the likely possibility that dysregulation in multiple ascending neuromodulatory systems and their interactions contribute essentially to the symptoms of these disorders. This review will paradigmatically focus on neuromodulator interactions in the PFC and be further constrained by an additional focus on their role in cognitive functions. Recent evidence indicates that individual neuromodulators, in addition to their general state-setting or gating functions, encode specific cognitive operations, further substantiating the importance of research concerning the parallel recruitment of neuromodulator systems and interactions between these systems.

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Research works printed but not linked: 2

  1. Grillner, 2000, Nicotine-induced excitation of midbrain dopamine neurons in vitro involves ionotropic glutamate receptor activation, Synapse, 38, 1, 10.1002/1098-2396(200010)38:1<1::AID-SYN1>3.0.CO;2-A · DOI
  2. Malone, 2004, Cortical projections of rat basal forebrain neurons: lack of axonal collateralization and similar topography of cholinergic and noncholinergic projections, J. Sleep Sleep Dis. Res., 27, A10

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Metadata

Authors
Briand, L. A., Gritton, H., Howe, W. M., Young, D. A., & Sarter, M.
Affiliations
University of Michigan (US)
Corresponding author
Sarter, Martin
ORCID
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2007-10
Volume
83
Issue
2
Pages
69-91
ISSN
0301-0082 (ISSN-L)
DOI
10.1016/j.pneurobio.2007.06.007
PMC
PMC2080765
OpenAlex
W1976205295
Cited by
216
References
326
Citations by year
2026: 4 · 2025: 17 · 2024: 9 · 2023: 8 · 2022: 15 · 2021: 11 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 12 · 2014: 11 · 2013: 16 · 2012: 17
FWCI
1.44
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (K02MH01072, R01MH063114, R01MH057436, MH 057436, MH073600, MH 063114, K02MH001072, R03MH073600)
  • National Institute of Neurological Disorders and Stroke (NS37026, R01NS037026)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
prefrontal cortex, noradrenergic system, dopaminergic system, serotonergic system, cholinergic system, cognitive function, neuropsychiatric disorders
MeSH terms
Animals, Cholinergic Fibers, Cognition, Dopamine, Humans, Neural Pathways, Norepinephrine, Serotonin, Prefrontal Cortex

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