The DOI matches its Crossref record; 323 of the 326 references it cites were found in a registry or an index.
Modulators in concert for cognition: Modulator interactions in the prefrontal cortex
Open accessAbstract
Research on the regulation and function of ascending noradrenergic, dopaminergic, serotonergic, and cholinergic systems has focused on the organization and function of individual systems. In contrast, evidence describing co-activation and interactions between multiple neuromodulatory systems has remained scarce. However, commonalities in the anatomical organization of these systems and overlapping evidence concerning the post-synaptic effects of neuromodulators strongly suggest that these systems are recruited in concert; they influence each other and simultaneously modulate their target circuits. Therefore, evidence on the regulatory and functional interactions between these systems is considered essential for revealing the role of neuromodulators. This postulate extends to contemporary neurobiological hypotheses of major neuropsychiatric disorders. These hypotheses have focused largely on aberrations in the integrity or regulation of individual ascending modulatory systems, with little regard for the likely possibility that dysregulation in multiple ascending neuromodulatory systems and their interactions contribute essentially to the symptoms of these disorders. This review will paradigmatically focus on neuromodulator interactions in the PFC and be further constrained by an additional focus on their role in cognitive functions. Recent evidence indicates that individual neuromodulators, in addition to their general state-setting or gating functions, encode specific cognitive operations, further substantiating the importance of research concerning the parallel recruitment of neuromodulator systems and interactions between these systems.
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“Although other neuromodulator systems, specifically the noradrenergic system (e.g., Witte and Marrocco, 1997; Posner, 2008), have been proposed to contribute to alerting, in the context of a circuitry model (below), we will suggest that a tonic component of cholinergic neurotransmission may also contribute to alerting and thereby to successful orienting, perhaps in part via local cortical and”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Briand et al, 2007
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The locus coeruleus and noradrenergic modulation of cognition
Sara, S. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2573 · Cited by 1,848
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Modes and models of forebrain cholinergic neuromodulation of cognition
Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733
Self-citation
Metadata
- Authors
- Briand, L. A., Gritton, H., Howe, W. M., Young, D. A., & Sarter, M.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Sarter, Martin
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 83
- Issue
- 2
- Pages
- 69-91
- ISSN
- 0301-0082 (ISSN-L)
- PMC
- PMC2080765
- OpenAlex
- W1976205295
- Cited by
- 216
- References
- 326
- Citations by year
- 2026: 4 · 2025: 17 · 2024: 9 · 2023: 8 · 2022: 15 · 2021: 11 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 12 · 2014: 11 · 2013: 16 · 2012: 17
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K02MH01072, R01MH063114, R01MH057436, MH 057436, MH073600, MH 063114, K02MH001072, R03MH073600)
- National Institute of Neurological Disorders and Stroke (NS37026, R01NS037026)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- prefrontal cortex, noradrenergic system, dopaminergic system, serotonergic system, cholinergic system, cognitive function, neuropsychiatric disorders
- MeSH terms
- Animals, Cholinergic Fibers, Cognition, Dopamine, Humans, Neural Pathways, Norepinephrine, Serotonin, Prefrontal Cortex
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