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Cited by 196Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex

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Xing, Bo, Li, Yan-Chun, Gao, Wen-Jun·2016·Brain Research
DOI 10.1016/j.brainres.2016.01.005PMC PMC4879059
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Abstract

Among the neuromodulators that regulate prefrontal cortical circuit function, the catecholamine transmitters norepinephrine (NE) and dopamine (DA) stand out as powerful players in working memory and attention. Perturbation of either NE or DA signaling is implicated in the pathogenesis of several neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), post-traumatic stress disorder (PTSD), schizophrenia, and drug addiction. Although the precise mechanisms employed by NE and DA to cooperatively control prefrontal functions are not fully understood, emerging research indicates that both transmitters regulate electrical and biochemical aspects of neuronal function by modulating convergent ionic and synaptic signaling in the prefrontal cortex (PFC). This review summarizes previous studies that investigated the effects of both NE and DA on excitatory and inhibitory transmissions in the prefrontal cortical circuitry. Specifically, we focus on the functional interaction between NE and DA in prefrontal cortical local circuitry, synaptic integration, signaling pathways, and receptor properties. Although it is clear that both NE and DA innervate the PFC extensively and modulate synaptic function by activating distinctly different receptor subtypes and signaling pathways, it remains unclear how these two systems coordinate their actions to optimize PFC function for appropriate behavior. Throughout this review, we provide perspectives and highlight several critical topics for future studies. This article is part of a Special Issue entitled SI: Noradrenergic System.

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Cited by

Sorted by citations

Authors
Xing, B., Li, Y.-C., & Gao, W.-J.
Affiliations
Drexel University (US)
Corresponding author
Gao, Wen-Jun
ORCID
Gao, Wen-Jun
Venue
Brain Research
Publisher
Elsevier BV
Published
2016-06
Volume
1641
Issue
Pt B
Pages
217-233
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2016.01.005
PMC
PMC4879059
OpenAlex
W2234486753
Cited by
196
References
29
Citations by year
2026: 16 · 2025: 32 · 2024: 17 · 2023: 16 · 2022: 26 · 2021: 27 · 2020: 22 · 2019: 14 · 2018: 10 · 2017: 11 · 2016: 5
FWCI
1.46
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (R01MH085666, R03MH101578)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
norepinephrine, dopamine, prefrontal cortex, synaptic modulation, catecholamines, neuromodulation, synaptic integration, receptor signaling pathways, noradrenergic system, working memory, attention, neuropsychiatric disorders
MeSH terms
Animals, Dopamine, Humans, Synaptic Transmission, Norepinephrine, Synapses, Prefrontal Cortex

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