The DOI matches its Crossref record; 357 of the 358 references it cites were found in a registry or an index.
The neuropharmacology of relapse to food seeking: Methodology, main findings, and comparison with relapse to drug seeking
Open accessAbstract
Relapse to old, unhealthy eating habits is a major problem in human dietary treatments. The mechanisms underlying this relapse are unknown. Surprisingly, until recently this clinical problem has not been systematically studied in animal models. Here, we review results from recent studies in which a reinstatement model (commonly used to study relapse to abused drugs) was employed to characterize the effect of pharmacological agents on relapse to food seeking induced by either food priming (non-contingent exposure to small amounts of food), cues previously associated with food, or injections of the pharmacological stressor yohimbine. We also address methodological issues related to the use of the reinstatement model to study relapse to food seeking, similarities and differences in mechanisms underlying reinstatement of food seeking versus drug seeking, and the degree to which the reinstatement procedure provides a suitable model for studying relapse in humans. We conclude by discussing implications for medication development and future research. We offer three tentative conclusions: (1)The neuronal mechanisms of food-priming- and cue-induced reinstatement are likely different from those of reinstatement induced by the pharmacological stressor yohimbine. (2)The neuronal mechanisms of reinstatement of food seeking are possibly different from those of ongoing food-reinforced operant responding. (3)The neuronal mechanisms underlying reinstatement of food seeking overlap to some degree with those of reinstatement of drug seeking.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Animal models of both food and drug reward have shown that after extinction, the behavior for drug or food consumption can be triggered either by exposure to the cue, the reward, or a stressor (34).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [34]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kilzer, E., & Skinner, B. F. (1953) · The American Catholic Sociological Review · doi:10.2307/3707860 · Cited by 8,940
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Selye, H. (1956) · Medical Entomology and Zoology · Cited by 5,224
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379
Morgan, J., & Curran, T. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002225 · Cited by 2,689
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
Research works printed but not linked: 5
- Baker, 1991, Contexual conditioning and reinstatement of extinguished instrumental responding, Quart. J. Exp. Psychol., 43B, 199
- Bremner, 1996, Noradrenergic mechanisms in stress and anxiety. II. Clinical studies, Synapse, 23, 39, 10.1002/(SICI)1098-2396(199605)23:1<39::AID-SYN5>3.0.CO;2-I · DOI
- Langlois, 2005, In vivo receptor occupancy profile of aripiprazole in rat brain, Soc. Neurosci. Abstracts, 444, 3
- Martin-Fardon, 2007, Differential effects of sigma1 receptor blockade on self-administration and conditioned reinstatement motivated by cocaine vs natural reward, Neuropsychopharmacology., 32, 1967, 10.1038/sj.npp.1301323 · DOI
- Nair, S., Adams-Deustch, T., Pickens, C., Smith, D., Shaham, Y., in press. Effect of the melenin concentrating hormone receptor 1 antagonist SNAP 94847 on food self-administration and relapse to food seeking in rats. Psychopharmacology.
Cited by
Sorted by citations
Items 101–112 of 112
Yin and yang in regulation of alcohol and sucrose intake by CRF1 and CRF2 receptors.
Timofeeva, E. (2010) · The Canadian Journal of Addiction · doi:10.1097/02024458-201012000-00001 · Cited by 2
Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction
Mansano, N. D. S., Lieu, C. V., & Abizaid, A. B. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.70104 · Cited by 2
McCormack, J. C., Roberts, R. P., Garratt, M., Wang, T., Hayes, J. E., & Peng, M. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.01.033 · Cited by 1
The Role of Ghrelin in Reward-Based Feeding
St-Onge, V. (2014) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2014-10569 · Cited by 1
Selected Neuropharmacology of Resurgence
Pyszczynski, A. D. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/d622-298f
Individual Variation in the Motivational Properties of Reward Cues.
Saunders, B. T. (2013) · Deep Blue (University of Michigan)
Carlin, J. L. (2014) · Scholarly Commons (University of Pennsylvania)
Individual Variation in the Extent to Which Drug Cues Acquire Control Over Motivated Behavior.
Yager, L. M. (2014) · Deep Blue (University of Michigan)
C URRENT OPINION Sugar addiction: pushing the drug-sugar analogy to the limit
Ahmed, S. H., Guillem, K., & Vandaele, Y. (2013)
Renewal In The Context Of Stress: A Potential Mechanism Of Stress-Induced Reinstatement
Schepers, S. T. (2017) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Spanagel, R., & Sommer, W. H. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.7162956.7397054
Marin, M. D. C. G. (2012) · theses.fr (ABES) · doi:10.70675/95b129bbz91cdz4c63zbd7dz07f9fc210c7a
Metadata
- Authors
- Nair, S. G., Adams-Deutsch, T., Epstein, D. H., & Shaham, Y.
- Affiliations
- National Institute on Drug Abuse (US)
- Corresponding author
- Shaham, Yavin
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 89
- Issue
- 1
- Pages
- 18-45
- ISSN
- 0301-0082 (ISSN-L)
- PMC
- PMC2745723
- OpenAlex
- W1974100279
- Cited by
- 112
- References
- 358
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 13 · 2013: 19 · 2012: 9
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (Z01DA000434)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- food cues, yohimbine, reinstatement of drug seeking, neuropharmacology, dietary therapy, food addiction, neural mechanisms, pharmacological stress
- MeSH terms
- Animals, Feeding and Eating Disorders, Behavior, Animal, Disease Models, Animal, Feeding Behavior, Food Preferences, Humans, Neuropharmacology, Yohimbine, Behavior, Addictive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
