Cited by 112Neurotransmitter Receptor Influence on BehaviorEating Disorders and BehaviorsRegulation of Appetite and Obesity

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The neuropharmacology of relapse to food seeking: Methodology, main findings, and comparison with relapse to drug seeking

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Nair, Sunila G., Adams-Deutsch, Tristan, Epstein, David H., Shaham, Yavin·2009·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2009.05.003PMC PMC2745723

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Abstract

Relapse to old, unhealthy eating habits is a major problem in human dietary treatments. The mechanisms underlying this relapse are unknown. Surprisingly, until recently this clinical problem has not been systematically studied in animal models. Here, we review results from recent studies in which a reinstatement model (commonly used to study relapse to abused drugs) was employed to characterize the effect of pharmacological agents on relapse to food seeking induced by either food priming (non-contingent exposure to small amounts of food), cues previously associated with food, or injections of the pharmacological stressor yohimbine. We also address methodological issues related to the use of the reinstatement model to study relapse to food seeking, similarities and differences in mechanisms underlying reinstatement of food seeking versus drug seeking, and the degree to which the reinstatement procedure provides a suitable model for studying relapse in humans. We conclude by discussing implications for medication development and future research. We offer three tentative conclusions: (1)The neuronal mechanisms of food-priming- and cue-induced reinstatement are likely different from those of reinstatement induced by the pharmacological stressor yohimbine. (2)The neuronal mechanisms of reinstatement of food seeking are possibly different from those of ongoing food-reinforced operant responding. (3)The neuronal mechanisms underlying reinstatement of food seeking overlap to some degree with those of reinstatement of drug seeking.

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Science and Human Behavior
Kilzer, E., & Skinner, B. F. (1953) · The American Catholic Sociological Review · doi:10.2307/3707860 · Cited by 8,940
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
The Stress of Life
Selye, H. (1956) · Medical Entomology and Zoology · Cited by 5,224
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379
Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
Morgan, J., & Curran, T. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002225 · Cited by 2,689
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity.
Kalivas, P., & Stewart, J. (1991) · Brain research. Brain research reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,087
Transposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019
Brain Dopamine and Reward
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968
Long-term weight loss maintenance
Wing, R. R., & Phelan, S. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.222s · Cited by 1,941
Molecular basis of long-term plasticity underlying addiction
Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,893
Meta‐analysis of cue‐reactivity in addiction research
Carter, B. L., & Tiffany, S. T. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9433273.x · Cited by 1,638
Relationship between stress, eating behavior, and obesity
Torres, S. J., & Nowson, C. A. (2007) · Nutrition · doi:10.1016/j.nut.2007.08.008 · Cited by 1,622
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615
Self-citation
The Epidemiology of Obesity
Ogden, C. L., Yanovski, S. Z., Carroll, M. D., & Flegal, K. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.052 · Cited by 1,561
How does stress increase risk of drug abuse and relapse?
Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,505
Epigenetic inheritance at the agouti locus in the mouse
Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics · doi:10.1038/15490 · Cited by 1,476
Chronic stress and obesity: a new view of “comfort food”
Dallman, M. F., Pecoraro, N., Akana, S. F., la Fleur, S. E., Gomez, F., Houshyar, H., Bell, M. E., Bhatnagar, S., Laugero, K. D., & Manalo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934666100 · Cited by 1,369
Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake
Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, J., Kanarek, R. B., & Maratos–Flier, E. (1996) · Nature · doi:10.1038/380243a0 · Cited by 1,320
A role for lateral hypothalamic orexin neurons in reward seeking
Harris, G. C., Wimmer, M., & Aston-Jones, G. (2005) · Nature · doi:10.1038/nature04071 · Cited by 1,311
Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues
Tzschentke, T. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00060-4 · Cited by 1,280
Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037/0033-295x.91.2.251 · Cited by 1,261
The Need to Feed
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
How can drug addiction help us understand obesity?
Volkow, N. D., & Wise, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1452 · Cited by 1,089
TASTE PREFERENCES AND FOOD INTAKE
Drewnowski, A. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.237 · Cited by 1,045
Dopamine receptor pharmacology
Seeman, P. M., & Tol, H. H. M. V. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90323-9 · Cited by 969
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
Rothman, R. B., Baumann, M. H., Dersch, C. M., Romero, D. V., Rice, K. C., Carroll, F. I., & Partilla, J. S. (2000) · Synapse · doi:10.1002/1098-2396(20010101)39:1 · Cited by 944
Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning
Kelley, A. E. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.015 · Cited by 942
Reinstatement of cocaine-reinforced responding in the rat
de Wit, H., & Stewart, J. (1981) · Psychopharmacology · doi:10.1007/bf00432175 · Cited by 928
Patient compliance with paper and electronic diaries
Stone, A. A., Shiffman, S., Schwartz, J. E., Broderick, J. E., & Hufford, M. R. (2003) · Controlled Clinical Trials · doi:10.1016/s0197-2456(02)00320-3 · Cited by 910
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
McFarland, K., & Kalivas, P. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08655.2001 · Cited by 905
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902
Neurobiology of relapse to heroin and cocaine seeking: a review
Shalev, U., Grimm, J. W., & Shaham, Y. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.1 · Cited by 880
Self-citation
Anxiety, restraint, and eating behavior.
Herman, C. P., & Polivy, J. (1975) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.84.6.666 · Cited by 860
The role of dopamine in locomotor activity and learning
Beninger, R. J. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90038-3 · Cited by 848
Contextual control of the extinction of conditioned fear
Bouton, M. E., & Bolles, R. C. (1979) · Learning and Motivation · doi:10.1016/0023-9690(79)90057-2 · Cited by 796
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
Conrad, K. L., Tseng, K. Y., Uejima, J. L., Reimers, J. M., Heng, L.-J., Shaham, Y., Marinelli, M., & Wolf, M. E. (2008) · Nature · doi:10.1038/nature06995 · Cited by 790
Self-citation
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
Baker, D. L., McFarland, K., LAKE, R. W., Shen, H., Tang, X., Toda, S., & Kalivas, P. W. (2003) · Nature Neuroscience · doi:10.1038/nn1069 · Cited by 740
Stress-induced relapse to heroin and cocaine seeking in rats: a review
Shaham, Y., Erb, S. M., & Stewart, J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00024-2 · Cited by 704
Self-citation
Role of dopamine in the behavioural actions of nicotine related to addiction
Chiara, G. D. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00122-9 · Cited by 698
Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System
Schoepp, D. D. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29296-x · Cited by 693
Perceived Effects of Stress on Food Choice
Oliver, G. D., & WARDLE, J. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00322-9 · Cited by 684
The role of stress in drug self-administration
Piazza, P. V., & Moal, M. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01115-2 · Cited by 674
Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides
Tatemoto, K., & Mutt, V. (1980) · Nature · doi:10.1038/285417a0 · Cited by 663
II. New evidence for a locus coeruleus-norepinephrine connection with anxiety
Redmond, D. E., & Huang, Y. H. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90087-0 · Cited by 662
Dynamics of Drug Dependence
Wikler, A. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.01750350005001 · Cited by 650
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
Epstein, D. H., Preston, K. L., Stewart, J., & Shaham, Y. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0529-6 · Cited by 627
Self-citation
Brain circuitry and the reinstatement of cocaine-seeking behavior
Kalivas, P., & McFarland, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1393-2 · Cited by 613
A motivational view of learning, performance, and behavior modification.
Bindra, D. (1974) · Psychological Review · doi:10.1037/h0036330 · Cited by 594
Promotion of sleep by targeting the orexin system in rats, dogs and humans
Roch, C., Dingemanse, J., Koberstein, R., Hoever, P., Aissaoui, H., Flores, S., Mueller, C., Nayler, O., van Gerven, J., de Haas, S. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1544 · Cited by 578
Obesity and Eating
Schachter, S. (1968) · Science · doi:10.1126/science.161.3843.751 · Cited by 561
Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction
Cornish, J. L., & Kalivas, P. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-j0006.2000 · Cited by 553
Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence
Colantuoni, C., Rada, P. V., McCarthy, J., Patten, C. S., Avena, N. M., Chadeayne, A., & Hoebel, B. G. (2002) · Obesity Research · doi:10.1038/oby.2002.66 · Cited by 544
A Historical View of the Stress Field
Mason, J. W. (1975) · Journal of Human Stress · doi:10.1080/0097840x.1975.9940399 · Cited by 532
Evidence for the involvement of TNF and NF-?B in hippocampal synaptic plasticity
Albensi, B. C., & Mattson, M. P. (2000) · Synapse · doi:10.1002/(sici)1098-2396(200002)35:2 · Cited by 527
Behavior, Health, and Environmental Stress
Cohen, S., Evans, G. W., Stokols, D., & Krantz, D. S. (1986) · Springer eBooks · doi:10.1007/978-1-4757-9380-2 · Cited by 521
Neuroplasticity in the mesolimbic dopamine system and cocaine addiction
Thomas, M. J., Kalivas, P. W., & Shaham, Y. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.77 · Cited by 521
Self-citation
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., & de Lecea, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507480102 · Cited by 520
The Role of the Dorsomedial Prefrontal Cortex, Basolateral Amygdala, and Dorsal Hippocampus in Contextual Reinstatement of Cocaine Seeking in Rats
Fuchs, R. A., Evans, K. A., Ledford, C. C., Parker, M. P., Case, J. M., Mehta, R. H., & See, R. E. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300579 · Cited by 517
The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor
Jordan, S., Koprivica, V., Chen, R., Tottori, K., Kikuchi, T., & Altar, C. A. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01532-7 · Cited by 512
Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
Borowsky, B., Durkin, M. M., Ogozalek, K. L., Marzabadi, M. R., DeLeon, J., Heurich, R. O., Lichtblau, H., Shaposhnik, Z., Daniewska, I., Blackburn, T. P., et al. (2002) · Nature Medicine · doi:10.1038/nm741 · Cited by 506
Context-induced relapse to drug seeking: a review
Crombag, H. S., Bossert, J. M., Koya, E., & Shaham, Y. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0090 · Cited by 498
Self-citation
Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1
Chambers, J. K., Ames, R. S., Bergsma, D. J., Muir, A. I., Fitzgerald, L. R., Hervieu, G. J., Dytko, G. M., Foley, J. J., Martin, J., Liu, W., et al. (1999) · Nature · doi:10.1038/22313 · Cited by 495
Opposite Modulation of Cocaine-Seeking Behavior by D 1 - and D 2 -Like Dopamine Receptor Agonists
Self, D. W., Barnhart, W. J., Lehman, D. A., & Nestler, E. J. (1996) · Science · doi:10.1126/science.271.5255.1586 · Cited by 492
PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans
Batterham, R. L., Ffytche, D. H., Rosenthal, J., Zelaya, F. O., Barker, G. J., Withers, D. J., & Williams, S. (2007) · Nature · doi:10.1038/nature06212 · Cited by 489
Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain
Colantuoni, C., Schwenker, J., McCarthy, J., Rada, P., Ladenheim, B., Cadet, J.-L., Schwartz, G. J., Moran, T. H., & Hoebel, B. G. (2001) · Neuroreport · doi:10.1097/00001756-200111160-00035 · Cited by 471
STRESSES AND STRAINS OF HOMEOSTASIS
Cannon, W. B. (1935) · The American Journal of the Medical Sciences · doi:10.1097/00000441-193501000-00001 · Cited by 451
Incubation of cocaine craving after withdrawal: a review of preclinical data
Lü, L., Grimm, J. W., Hope, B. T., & Shaham, Y. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.027 · Cited by 443
Self-citation
Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure
Salamone, J. D., Steinpreis, R. E., McCullough, L. D., Smith, P., Grebel, D., & Mahan, K. (1991) · Psychopharmacology · doi:10.1007/bf02245659 · Cited by 436
A cannabinoid mechanism in relapse to cocaine seeking
Vries, T. J. D., Shaham, Y., Homberg, J. R., Crombag, H. S., Schuurman, K. G., Dieben, J., Vanderschuren, L. J. M. J., & Schoffelmeer, A. N. M. (2001) · Nature Medicine · doi:10.1038/nm1001-1151 · Cited by 433
Self-citation
Maintenance and relapse after weight loss in women: behavioral aspects
Kayman, S., Bruvold, W. H., & Stern, J. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.5.800 · Cited by 433
α 2 -Adrenoceptor-Mediated Hyperpolarization of Locus Coeruleus Neurons: Intracellular Studies in Vivo
Aghajanian, G. K., & VanderMaelen, C. P. (1982) · Science · doi:10.1126/science.6278591 · Cited by 431
The neurocircuitry of addiction: an overview
Feltenstein, M. W., & See, R. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.51 · Cited by 421
Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens
Weiss, F., Maldonado-Vlaar, C. S., Parsons, L. H., Kerr, T. M., Smith, D. L., & Ben‐Shahar, O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4321 · Cited by 416
A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats
Capriles, N., Rodaros, D., Sorge, R. E., & Stewart, J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1283-z · Cited by 414
What predicts weight regain in a group of successful weight losers?
McGuire, M. T., Wing, R. R., Klem, M. L., Lang, W., & Hill, J. O. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.67.2.177 · Cited by 412
Neurobiology of craving, conditioned reward and relapse
Weiss, F. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.11.001 · Cited by 411
Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period
Erb, S. M., Shaham, Y., & Stewart, J. (1996) · Psychopharmacology · doi:10.1007/s002130050150 · Cited by 406
Self-citation
Selective inactivation of the dorsomedial prefrontal cortex and the basolateral amygdala attenuates conditioned-cued reinstatement of extinguished cocaine-seeking behavior in rats
McLaughlin, J., & See, R. E. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1196-x · Cited by 402
Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis
Kuczenski, R. T., & Segal, D. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-06-02051.1989 · Cited by 398
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity
Cosford, N. D. P., Tehrani, L. R., Roppe, J. R., Schweiger, E. J., Smith, N. D., Anderson, J., Bristow, L. J., Brodkin, J. D., Jiang, X., McDonald, I. A., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm025570j · Cited by 397
The orexin system regulates alcohol-seeking in rats
Lawrence, A. J., Cowen, M. S., Yang, H., Chen, F., & Oldfield, B. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706789 · Cited by 392
Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain
Saito, Y., Cheng, M., Leslie, F. M., & Civelli, O. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1191 · Cited by 381
Renewal of drug seeking by contextual cues after prolonged extinction in rats.
Crombag, H. S., & Shaham, Y. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.1.169 · Cited by 380
Self-citation
Long-term follow-up of behavioral treatment for obesity: patterns of weight regain among men and women.
Kramer, F. M., Jeffery, R. W., Forster, J. L., & Snell, M. K. (1989) · PubMed · Cited by 378
Fos: An immediate‐early transcription factor in neurons
Curran, T., & Morgan, J. I. (1995) · Journal of Neurobiology · doi:10.1002/neu.480260312 · Cited by 377
Cocaine-induced cocaine craving
Jaffe, J. H., Cascella, N. G., Kumor, K. M., & Sherer, M. A. (1989) · Psychopharmacology · doi:10.1007/bf00443414 · Cited by 373
Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking
Wang, B., Shaham, Y., Zitzman, D., Azari, S., Wise, R. A., & You, Z.-B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0955-05.2005 · Cited by 369
Self-citation
Chapter 19 The determinants of stress-induced activation of the prefrontal cortical dopamine system
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62691-6 · Cited by 364
Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.
Stewart, J. (2000) · PubMed Central · Cited by 361
Stress reinstates heroin-seeking in drug-free animals: An effect mimicking heroin, not withdrawal
Shaham, Y., & Stewart, J. (1995) · Psychopharmacology · doi:10.1007/bf02246300 · Cited by 361
Self-citation
Sources of relapse after extinction in Pavlovian and instrumental learning
Bouton, M. E., & Swartzentruber, D. (1991) · Clinical Psychology Review · doi:10.1016/0272-7358(91)90091-8 · Cited by 352
Yohimbine induced anxiety and increased noradrenergic function in humans: Effects of diazepam and clonidine
Charney, D. S., Heninger, G. R., & Redmond, D. E. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90707-5 · Cited by 348
A Role for the Bed Nucleus of the Stria Terminalis, But Not the Amygdala, in the Effects of Corticotropin-Releasing Factor on Stress-Induced Reinstatement of Cocaine Seeking
Erb, S. M., & Stewart, J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-j0006.1999 · Cited by 347
Characterization of hippocampal norepinephrine release as measured by microdialysis perfusion: pharmacological and behavioral studies.
Abercrombie, E., Keller, R., & Zigmond, M. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90192-3 · Cited by 342
Drug‐induced reinstatement of heroin‐ and cocaine‐seeking behaviour following long‐term extinction is associated with expression of behavioural sensitization
Vries, T. J. D., Schoffelmeer, A. N. M., Binnekade, R., Mulder, A. H., & Vanderschuren, L. J. M. J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00368.x · Cited by 332
The Role of Corticotropin-Releasing Factor and Corticosterone in Stress- and Cocaine-Induced Relapse to Cocaine Seeking in Rats
Erb, S. M., Shaham, Y., & Stewart, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05529.1998 · Cited by 329
Self-citation
Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour
Sutton, M. A., Schmidt, E. F., Choi, K.-H., Schad, C. A., Whisler, K., Simmons, D. L., Karanian, D. A., Monteggia, L. M., Neve, R. L., & Self, D. W. (2003) · Nature · doi:10.1038/nature01249 · Cited by 328
Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior
Self, D. W., Genova, L. M., Hope, B. T., Barnhart, W. J., Spencer, J. J., & Nestler, E. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01848.1998 · Cited by 325
Cocaine-induced conditioned place preference: reinstatement by priming injections of cocaine after extinction
Mueller, D. T., & Stewart, J. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00239-4 · Cited by 324
"Craving" and Relapse to Drink
Ludwig, A. M., & Wikler, A. (1974) · Quarterly Journal of Studies on Alcohol · doi:10.15288/qjsa.1974.35.108 · Cited by 322
Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats
Lê, A. D., Quan, B. H., Juzytsch, W., Fletcher, P. J., Joharchi, N., & Shaham, Y. (1998) · Psychopharmacology · doi:10.1007/s002130050498 · Cited by 319
Self-citation
Weight maintenance and relapse in obesity: a qualitative study
Byrne, S., Cooper, Z., & Fairburn, C. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802305 · Cited by 318
The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats
Lê, A. D., Harding, S. E., Juzytsch, W., Watchus, J., Shalev, U., & Shaham, Y. (2000) · Psychopharmacology · doi:10.1007/s002130000411 · Cited by 310
Self-citation
Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens
Park, W.-K., Bari, A., Jey, A. R., Anderson, S. M., Spealman, R. D., Rowlett, J. K., & Pierce, R. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02916.2002 · Cited by 310
Corticotropin-Releasing Factor, But Not Corticosterone, Is Involved in Stress-Induced Relapse to Heroin-Seeking in Rats
Shaham, Y., Funk, D., Erb, S., Brown, T. J., Walker, C.-D., & Stewart, J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02605.1997 · Cited by 308
Self-citation
Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement.
Whitelaw, R. B., Markou, A., Robbins, T. W., & Everitt, B. J. (1996) · PubMed · Cited by 306
Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour
Everitt, B. J., & Robbins, T. W. (2000) · Psychopharmacology · doi:10.1007/s002130000566 · Cited by 305
Autonomic and psychic effects of yohimbine hydrochloride
Holmberg, G., & Gershon, S. (1961) · Psychopharmacology · doi:10.1007/bf00592678 · Cited by 303
Real-Time Electronic Diary Reports of Cue Exposure and Mood in the Hours Before Cocaine and Heroin Craving and Use
Epstein, D. H., Willner‐Reid, J., Vahabzadeh, M., Mezghanni, M., Lin, J., & Preston, K. L. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.509 · Cited by 301
Self-citation
Psychosocial Factors in Athletic Injuries: Development and Application of the Social and Athletic Readjustment Rating Scale (SARRS)
Bramwell, S. T., Masuda, M., Wagner, N. N., & Holmes, T. H. (1975) · Journal of Human Stress · doi:10.1080/0097840x.1975.9940404 · Cited by 297
The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse
Shepard, J. D., Bossert, J. M., Liu, S. Y., & Shaham, Y. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.032 · Cited by 295
Self-citation
Does gut hormone PYY3–36 decrease food intake in rodents?
Tschöp, M., Castañeda, T. R., Joost, H., Thöne‐Reineke, C., Ortmann, S., Klaus, S., Hagan, M., Chandler-Laney, P. C., Oswald, K. D., Benoit, S. C., et al. (2004) · Nature · doi:10.1038/nature02665 · Cited by 295
CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking
Anderson, S. M., Famous, K. R., Sadri-Vakili, G., Kumaresan, V., Schmidt, H. D., Bass, C. E., Terwilliger, E. F., Cha, J.-H. J., & Pierce, R. C. (2008) · Nature Neuroscience · doi:10.1038/nn2054 · Cited by 295
Differential Effects of Blockade of Dopamine D 1 -Family Receptors in Nucleus Accumbens Core or Shell on Reinstatement of Heroin Seeking Induced by Contextual and Discrete Cues
Bossert, J. M., Poles, G. C., Wihbey, K. A., Koya, E., & Shaham, Y. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3926-07.2007 · Cited by 292
Self-citation
Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review
Lü, L., Shepard, J. D., Hall, F. S., & Shaham, Y. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00073-3 · Cited by 285
Self-citation
The validity of the reinstatement model of craving and relapse to drug use
Katz, J. L., & Higgins, S. T. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1441-y · Cited by 273
Priming effects with drugs and other reinforcers.
de Wit, H. (1996) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.4.1.5 · Cited by 272
Neurobiology of relapse to heroin and cocaine seeking: An update and clinical implications
Bossert, J. M., Ghitza, U. E., Lü, L., Epstein, D. H., & Shaham, Y. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.030 · Cited by 271
Self-citation
Alpha-2 Adrenergic Receptor Agonists Block Stress-Induced Reinstatement of Cocaine Seeking
Erb, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00158-x · Cited by 270
Noradrenergic agonists and antagonists: Effects on conditioned fear as measured by the potentiated startle paradigm
Davis, M., Redmond, D. E., & Baraban, J. M. (1979) · Psychopharmacology · doi:10.1007/bf00433036 · Cited by 258
Cocaine-but not food-seeking behavior is reinstated by stress after extinction
Ahmed, S. H., & Koob, G. F. (1997) · Psychopharmacology · doi:10.1007/s002130050347 · Cited by 257
The hardship of obesity: a soft-wired hypothalamus
Horváth, T. L. (2005) · Nature Neuroscience · doi:10.1038/nn1453 · Cited by 256
Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats
L�, A. D., Harding, S., Juzytsch, W., Funk, D. R., & Shaham, Y. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2036-y · Cited by 254
Self-citation
The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor
Lembo, P. M. C., Grazzini, E., Cao, J., Hubatsch, D. A., Pelletier, M., Hoffert, C., St-Onge, S., Pou, C., Labrecque, J., Groblewski, T., et al. (1999) · Nature Cell Biology · doi:10.1038/12978 · Cited by 253
Role of conditioned reinforcers in the initiation, maintenance and extinction of drug-seeking behavior
Davis, W. M., & Smith, S. G. (1976) · Pavlovian Journal of Biological Science · doi:10.1007/bf03000316 · Cited by 251
The cerebral ventricles as the avenue for the dipsogenic action of intracranial angiotensin
Johnson, A. K., & Epstein, A. N. (1975) · Brain Research · doi:10.1016/0006-8993(75)90891-4 · Cited by 250
Gut Peptides in the Regulation of Food Intake and Energy Homeostasis
Murphy, K. G., Dhillo, W. S., & Bloom, S. R. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0028 · Cited by 248
Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats
Fuchs, R. A., Evans, K. A., Parker, M. P., & See, R. E. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1895-6 · Cited by 242
A Role of Ventral Tegmental Area Glutamate in Contextual Cue-Induced Relapse to Heroin Seeking
Bossert, J. M., Liu, S. Y., Lu, L., & Shaham, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3207-04.2004 · Cited by 241
Self-citation
Role of ventral medial prefrontal cortex in incubation of cocaine craving
Koya, E., Uejima, J. L., Wihbey, K. A., Bossert, J. M., Hope, B. T., & Shaham, Y. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.022 · Cited by 239
Self-citation
Mental activity in relaxed wakefulness.
Foulkes, D., & Fleisher, S. (1975) · Journal of Abnormal Psychology · doi:10.1037/h0076164 · Cited by 235
Preferential Effects of the Metabotropic Glutamate 2/3 Receptor Agonist LY379268 on Conditioned Reinstatement versus Primary Reinforcement: Comparison between Cocaine and a Potent Conventional Reinforcer
Baptista, M. A. S., Martin‐Fardon, R., & Weiss, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0176-04.2004 · Cited by 235
Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats
Richards, J. K., Simms, J. A., Steensland, P., Taha, S. A., Borgland, S. L., Bonci, A., & Bartlett, S. E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1136-5 · Cited by 234
Neural substrates of cocaine-cue associations that trigger relapse
See, R. E. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.034 · Cited by 228
Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement
Whitelaw, R. B., Markou, A., Robbins, T. W., & Everitt, B. J. (1996) · Psychopharmacology · doi:10.1007/bf02805996 · Cited by 228
Conditioned cued recovery of responding following prolonged withdrawal from self-administered cocaine in rats: an animal model of relapse.
Meil, W. M., & See, R. E. (1996) · PubMed · Cited by 225
Critical assessment of how to study addiction and its treatment: Human and non-human animal models
O’Brien, C. P., & Gardner, E. L. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.018 · Cited by 224
D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
Nowend, K. L., Arizzi, M. N., Carlson, B. B., & Salamone, J. D. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00524-x · Cited by 223
Rate-dependent effects of drugs: A review of the literature
Sanger, D. J., & Blackman, D. E. (1976) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(76)90178-7 · Cited by 221
Lateral hypothalamic neuropeptides in reward and drug addiction
Dileone, R., Georgescu, D., & Nestler, E. J. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00408-9 · Cited by 220
Microdialysis Studies of Brain Norepinephrine, Serotonin, and Dopamine Release During Ingestive Behavior Theoretical and Clinical Implicationsa
HOEBEL, B. G., HERNANDEZ, L., SCHWARTZ, D. H., MARK, G. P., & HUNTER, G. A. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb53242.x · Cited by 220
Cannabinoid CB1 receptors control conditioned drug seeking
Vries, T. J. D., & Schoffelmeer, A. N. M. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.06.002 · Cited by 219
Dissociation of Primary and Secondary Reward-Relevant Limbic Nuclei in an Animal Model of Relapse
Grimm, J. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00157-8 · Cited by 215
Peptide YY(1-36) and Peptide YY(3-36): Part I. Distribution, Release and Actions
Ballantyne, G. H. (2006) · Obesity Surgery · doi:10.1381/096089206776944959 · Cited by 212
Antidopaminergic properties of yohimbine.
Scatton, B., Živković, B., & Dedek, J. (1980) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32325-6 · Cited by 211
Reinstatement of heroin and cocaine self-administration behavior in the rat by intracerebral application of morphine in the ventral tegmental area
Stewart, J. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(84)90017-0 · Cited by 210
Expanding the Scales: The Multiple Roles of MCH in Regulating Energy Balance and Other Biological Functions
Pissios, P., Bradley, R. L., & Maratos–Flier, E. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0021 · Cited by 209
Enduring Resistance to Extinction of Cocaine-Seeking Behavior Induced by Drug-Related Cues
Weiss, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00238-x · Cited by 207
The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse
Rogers, J. L., Ghee, S. M., & See, R. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.012 · Cited by 207
Stress reinstates nicotine seeking but not sucrose solution seeking in rats
Buczek, Y., Lê, A. D., Wang, A., Stewart, J., & Shaham, Y. (1999) · Psychopharmacology · doi:10.1007/s002130050992 · Cited by 206
Self-citation
Comparison of 2-Year Weight Loss Trends in Behavioral Treatments of Obesity
Skender, M. L., Goodrick, G. K., del Junco, D. J., Reeves, R. S., Darnell, L. S., Gotto, A. M., & Foreyt, J. P. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00096-x · Cited by 202
Clonidine blocks stress-induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons
Shaham, Y., Highfield, D., Delfs, J., Leung, S., & Stewart, J. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00899.x · Cited by 201
Self-citation
Relapse to Cocaine- and Heroin-Seeking Behavior Mediated by Dopamine D2 Receptors Is Time-Dependent and Associated with Behavioral Sensitization
Vries, T. J. D. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00293-7 · Cited by 200
Dopamine D1- and D2-Like Receptor Mechanisms in Relapse to Cocaine-Seeking Behavior: Effects of Selective Antagonists and Agonists
Khroyan, T. V., Barrett-Larimore, R. L., Rowlett, J. K., & Spealman, R. D. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39122-0 · Cited by 198
Stress and relapse to drug seeking in rats: studies on the generality of the effect
Shalev, U., Highfield, D. A., Yap, J. J., & Shaham, Y. (2000) · Psychopharmacology · doi:10.1007/s002130000441 · Cited by 198
Self-citation
Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats
Vries, T. J. D., Homberg, J. R., Binnekade, R., Raasø, H. S., & Schoffelmeer, A. N. M. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1422-1 · Cited by 197
Observational analysis of feeding induced by Δ9-THC and anandamide
Williams, C. M., & Kirkham, T. C. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00725-4 · Cited by 195
Corticosteroids and the Control of Function in the Hypothalamo‐Pituitary‐Adrenal (HPA) Axisa
Dallman, M. F., Akana, S. F., LEVIN, N., Walker, C. D., BRADBURY, M. J., Suemaru, S., & SCRIBNER, K. S. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39206.x · Cited by 195
Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats
Shaham, Y., & Stewart, J. (1996) · Psychopharmacology · doi:10.1007/bf02246022 · Cited by 194
Self-citation
Metabotropic Glutamate 2/3 Receptors in the Ventral Tegmental Area and the Nucleus Accumbens Shell Are Involved in Behaviors Relating to Nicotine Dependence
Liechti, M. E., Lhuillier, L., Kaupmann, K., & Markou, A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1766-07.2007 · Cited by 193
Basolateral amygdala inactivation abolishes conditioned stimulus- and heroin-induced reinstatement of extinguished heroin-seeking behavior in rats
Fuchs, R. A., & See, R. E. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0997-7 · Cited by 193
Systemic and Central Amygdala Injections of the mGluR2/3 Agonist LY379268 Attenuate the Expression of Incubation of Cocaine Craving
Lü, L., Uejima, J. L., Gray, S. M., Bossert, J. M., & Shaham, Y. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.011 · Cited by 192
Self-citation
Erratum: Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
Borowsky, B., Durkin, M. M., Ogozalek, K. L., Marzabadi, M. R., DeLeon, J., Heurich, R. O., Lichtblau, H., Shaposhnik, Z., Daniewska, I., Blackburn, T. P., et al. (2002) · Nature Medicine · doi:10.1038/nm0902-1039b · Cited by 192
The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats
Marinelli, P. W., Funk, D. R., Juzytsch, W., Harding, S. E., Rice, K. C., Shaham, Y., & Lê, A. D. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0905-x · Cited by 191
Self-citation
Serotonin and Dopamine Sensitization in the Nucleus Accumbens, Ventral Tegmental Area, and Dorsal Raphe Nucleus Following Repeated Cocaine Administration
Parsons, L. H., & Justice, J. B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09794.x · Cited by 190
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats
Peters, J., & Kalivas, P. W. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0372-9 · Cited by 190
Regulation of drug-taking and-seeking behaviors by neuroadaptations in the mesolimbic dopamine system
Self, D. W. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.005 · Cited by 189
Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell‐line using FLIPR
Smart, D., Jerman, J. C., Brough, S. J., Rushton, S. L., Murdock, P. R., Jewitt, F., Elshourbagy, N. A., Ellis, C. E., Middlemiss, D. N., & Brown, F. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702780 · Cited by 189
The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking
Hamlin, A. S., Newby, J. M., & McNally, G. P. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.063 · Cited by 188
Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity
Little, T. J., Horowitz, M., & Feinle‐Bisset, C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.531 · Cited by 184
Leptin Attenuates Acute Food Deprivation-Induced Relapse to Heroin Seeking
Shalev, U., Yap, J. J., & Shaham, Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-j0001.2001 · Cited by 184
Self-citation
Drugs of abuse: behavioural principles, methods and terms
Stolerman, I. P. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90059-f · Cited by 182
Renewal of Extinguished Lever-Press Responses upon Return to the Training Context
Nakajima, S., Tanaka, S., Urushihara, K., & Imada, H. (2000) · Learning and Motivation · doi:10.1006/lmot.2000.1064 · Cited by 181
Therapeutic and adverse actions of serotonin transporter substrates
Rothman, R. B., & Baumann, M. H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00234-6 · Cited by 181
Opioids and consummatory behavior
Levine, A. S., Morley, J. E., Gosnell, B. A., Billington, C. J., & Bartness, T. J. (1985) · Brain Research Bulletin · doi:10.1016/0361-9230(85)90116-9 · Cited by 180
Amygdala and "emotional" modulation of the relative use of multiple memory systems.
Packard, M., & Wingard, J. C. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.06.008 · Cited by 179
Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats
Anderson, S. M., Bari, A. A., & Pierce, R. C. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1298-5 · Cited by 178
Relapse crises and coping among dieters.
Grilo, C. M., Shiffman, S., & Wing, R. R. (1989) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.57.4.488 · Cited by 175
Clinical significance of adaptive thermogenesis
Major, G., Doucet, É., Trayhurn, P., Astrup, A. V., & Tremblay, A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803523 · Cited by 175
Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats
Wise, R. A., Murray, A., & Bozarth, M. A. (1990) · Psychopharmacology · doi:10.1007/bf02244606 · Cited by 174
Pharmacological and Environmental Determinants of Relapse to Cocaine-Seeking Behavior
Spealman, R. D., Barrett-Larimore, R. L., Rowlett, J. K., Platt, D. M., & Khroyan, T. V. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00049-0 · Cited by 173
Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking
Schmidt, H. D., Anderson, S. M., Famous, K. R., Kumaresan, V., & Pierce, R. C. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.068 · Cited by 170
Renewal of extinguished cocaine-seeking
Hamlin, A. S., Clemens, K. J., & McNally, G. P. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.11.018 · Cited by 170
Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats
Economidou, D., Mattioli, L., Cifani, C., Perfumi, M. C., Massi, M., Cuomo, V., Trabace, L., & Ciccocioppo, R. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0199-9 · Cited by 169
Pharmacological Treatment of the Overweight Patient
Bray, G. A., & Greenway, F. L. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.2.2 · Cited by 169
Nicotine increases alcohol self-administration and reinstates alcohol seeking in rats
Lê, A. D., Wang, A. A., Harding, S. E., Juzytsch, W., & Shaham, Y. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1330-9 · Cited by 169
Self-citation
Comparison of the ?-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine
Doxey, J. C., Lane, A. C., Roach, A. G., & Virdce, N. K. (1984) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00506193 · Cited by 166
Medications development: Successes and challenges
Vocci, F. J., & Ling, W. W. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.010 · Cited by 161
Manipulation of dopamine d1-like receptor activation in the rat medial prefrontal cortex alters stress- and cocaine-induced reinstatement of conditioned place preference behavior
Sanchez, C. J., Bailie, T. M., Wu, W.-R., Li, N., & Sorg, B. A. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00078-2 · Cited by 160
Pharmacological Blockade of α2-Adrenoceptors Induces Reinstatement of Cocaine-Seeking Behavior in Squirrel Monkeys
Lee, B., Tiefenbacher, S., Platt, D. M., & Spealman, R. D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300391 · Cited by 160
Midbrain dopamine system electrophysiological functioning: A review and new hypothesis
Bunney, B. S., Chiodo, L. A., & Grace, A. A. (1991) · Synapse · doi:10.1002/syn.890090202 · Cited by 159
The Anxiogenic Drug Yohimbine Reinstates Palatable Food Seeking in a Rat Relapse Model: a Role of CRF1 Receptors
Ghitza, U. E., Gray, S. M., Epstein, D. H., Rice, K. C., & Shaham, Y. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300964 · Cited by 154
Self-citation

Research works printed but not linked: 5

Baker, 1991, Contexual conditioning and reinstatement of extinguished instrumental responding, Quart. J. Exp. Psychol., 43B, 199
Bremner, 1996, Noradrenergic mechanisms in stress and anxiety. II. Clinical studies, Synapse, 23, 39, 10.1002/(SICI)1098-2396(199605)23:1<39::AID-SYN5>3.0.CO;2-I · DOI
Langlois, 2005, In vivo receptor occupancy profile of aripiprazole in rat brain, Soc. Neurosci. Abstracts, 444, 3
Martin-Fardon, 2007, Differential effects of sigma1 receptor blockade on self-administration and conditioned reinstatement motivated by cocaine vs natural reward, Neuropsychopharmacology., 32, 1967, 10.1038/sj.npp.1301323 · DOI
Nair, S., Adams-Deustch, T., Pickens, C., Smith, D., Shaham, Y., in press. Effect of the melenin concentrating hormone receptor 1 antagonist SNAP 94847 on food self-administration and relapse to food seeking in rats. Psychopharmacology.

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See all 112

Authors: Nair, S. G., Adams-Deutsch, T., Epstein, D. H., & Shaham, Y.
Affiliations: National Institute on Drug Abuse (US)
Corresponding author: Shaham, Yavin
ORCID: Nair, Sunila G.
Epstein, David H.
Shaham, Yavin
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2009-09
Volume: 89
Issue: 1
Pages: 18-45
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2009.05.003
PMC: PMC2745723
OpenAlex: W1974100279
Cited by: 112
References: 358
Citations by year: 2025: 1 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 13 · 2013: 19 · 2012: 9
FWCI: 1.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (Z01DA000434)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: food cues, yohimbine, reinstatement of drug seeking, neuropharmacology, dietary therapy, food addiction, neural mechanisms, pharmacological stress
MeSH terms: Animals, Feeding and Eating Disorders, Behavior, Animal, Disease Models, Animal, Feeding Behavior, Food Preferences, Humans, Neuropharmacology, Yohimbine, Behavior, Addictive

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The neuropharmacology of relapse to food seeking: Methodology, main findings, and comparison with relapse to drug seeking

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