The DOI matches its Crossref record; 375 of the 375 references it cites were found in a registry or an index.
The synapsins: Key actors of synapse function and plasticity
Abstract
The synapsins are a family of neuronal phosphoproteins evolutionarily conserved in invertebrate and vertebrate organisms. Their best-characterised function is to modulate neurotransmitter release at the pre-synaptic terminal, by reversibly tethering synaptic vesicles (SVs) to the actin cytoskeleton. However, many recent data have suggested novel functions for synapsins in other aspects of the pre-synaptic physiology, such as SV docking, fusion and recycling. Synapsin activity is tightly regulated by several protein kinases and phosphatases, which modulate the association of synapsins to SVs as well as their interaction with actin filaments and other synaptic proteins. In this context, synapsins act as a link between extracellular stimuli and the intracellular signalling events activated upon neuronal stimulation. Genetic manipulation of synapsins in various in vivo models has revealed that, although not essential for the basic development and functioning of neuronal networks, these proteins are extremely important in the fine-tuning of neuronal plasticity, as shown by the epileptic phenotype and behavioural abnormalities characterising mouse lines lacking one or more synapsin isoforms. In this review, we summarise the current knowledge about how the various members of the synapsin family are involved in the modulation of the pre-synaptic physiology. We give a comprehensive description of the molecular basis of synapsin function, as well as an overview of the more recent evidence linking mutations in the synapsin proteins to the onset of severe central nervous system diseases such as epilepsy and schizophrenia.
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“These synapsins are critical in synapse function and plasticity.166”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [166]
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The Cell Biology of Synaptic Plasticity
Ho, V. M., Lee, J.-A., & Martin, K. C. (2011) · Science · doi:10.1126/science.1209236 · Cited by 573
Short-term forms of presynaptic plasticity
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Synaptic vesicle recycling: steps and principles
Rizzoli, S. O. (2014) · The EMBO Journal · doi:10.1002/embj.201386357 · Cited by 317
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
“166 Other forms of histone methylation include H3K9me2 and H3K27me3, are repressive in the gene promoter region in response to stress.”
BackgroundDevelopmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
Guerrini, R., Conti, V., Mantegazza, M., Balestrini, S., Galanopoulou, A. S., & Benfenati, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00063.2021 · Cited by 196
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Metadata
- Authors
- Cesca, F., Baldelli, P., Valtorta, F., & Benfenati, F.
- Affiliations
- Italian Institute of Technology (IT)
- Vita-Salute San Raffaele University (IT)
- Corresponding author
- Benfenati, F.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 91
- Issue
- 4
- Pages
- 313-348
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2142790764
- Cited by
- 654
- References
- 375
- Citations by year
- 2026: 35 · 2025: 52 · 2024: 39 · 2023: 34 · 2022: 50 · 2021: 39 · 2020: 38 · 2019: 41 · 2018: 45 · 2017: 44 · 2016: 37 · 2015: 34 · 2014: 36 · 2013: 49 · 2012: 40
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- synapsin, synaptic vesicle tethering, neurotransmitter release, synaptic vesicle recycling, actin cytoskeleton, kinase regulation, synaptic plasticity, epilepsy, schizophrenia, central nervous system disorders
- MeSH terms
- Animals, Models, Biological, Neuronal Plasticity, Neurons, Phosphorylation, Protein Binding, Synapses, Synapsins
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