Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

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Structure and function of the blood–brain barrier

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

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Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

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Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

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Mitophagy and iron: two actors sharing the stage in age-associated neuronal pathologies

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Different iron deposition patterns in akinetic/rigid-dominant and tremor-dominant Parkinson's disease

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High-resolution mapping of substantia nigra in Parkinson’s disease using 7 tesla magnetic resonance imaging

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Early brain iron changes in Parkinson's disease and isolated rapid eye movement sleep behaviour disorder: a four-year longitudinal multimodal quantitative MRI study

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MRI T2 and T2* relaxometry to visualize neuromelanin in the dorsal substantia nigra pars compacta

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Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox

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Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory

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Dl-3-n-butylphthalide activates Nrf2, inhibits ferritinophagy, and protects MES23.5 dopaminergic neurons from ferroptosis

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Role of Artificial Intelligence Techniques and Neuroimaging Modalities in Detection of Parkinson’s Disease: A Systematic Review

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Prion Peptides Are Extremely Sensitive to Copper Induced Oxidative Stress

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Antilisterial activity of dromedary lactoferrin peptic hydrolysates

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Surface Water Quality in the Mantaro River Watershed Assessed after the Cessation of Anthropogenic Activities Due to the COVID-19 Pandemic

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Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer’s pathology stages

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Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI)

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Neuromelanin formation exacerbates HAA-induced mitochondrial toxicity and mitophagy impairments

Lawana, V., Um, S. Y., Foguth, R. M., & Cannon, J. R. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.10.005 · Cited by 18

Association between dietary intake and risk of Parkinson’s disease: cross-sectional analysis of survey data from NHANES 2007–2016

Liu, L., Shen, Q., Bao, Y., Xu, F., Zhang, D., Huang, H., Tu, L.-D., & Xu, Y. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1278128 · Cited by 20

Sex Differences in Locus Coeruleus: A Heuristic Approach That May Explain the Increased Risk of Alzheimer’s Disease in Females

Luckey, A. M., Robertson, I. H., LAWLOR, B. A., Mohan, A., & Vanneste, S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210404 · Cited by 24

Discerning the antioxidant mechanism of rapanone: A naturally occurring benzoquinone with iron complexing and radical scavenging activities

de la Vega‐Hernández, K., Antuch, M., Cuesta‐Rubio, O., Núñez-Figueredo, Y., & Andreu, G. L. P. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.02.019 · Cited by 21

Pool size ratio of the substantia nigra in Parkinson’s disease derived from two different quantitative magnetization transfer approaches

Trujillo, P., Summers, P. E., Smith, A. K., Smith, S. A., Mainardi, L. T., Cerutti, S., Claassen, D. O., & Costa, A. (2017) · Neuroradiology · doi:10.1007/s00234-017-1911-2 · Cited by 22

Iron and copper ions accelerate and modify dopamine oxidation to eumelanin: implications for neuromelanin genesis

Ito, S., Napolitano, A., Sarna, T., & Wakamatsu, K. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-022-02574-6 · Cited by 18

Ozone Environmental Pollution: Relationship between the Intestine and Neurodegenerative Diseases

Rivas-Arancibia, S., Miranda-Martínez, A., Rodrı́guez-Martı́nez, E., Hernández-Orozco, E., Valdés‐Fuentes, M., & la Rosa-Sierra, R. D. (2023) · Antioxidants · doi:10.3390/antiox12071323 · Cited by 18

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Yang, L., Nao, J., & Dong, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c02787 · Cited by 19

Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis

Yang, M., Yang, H., Guan, H., Bellier, J., Zhao, S., & Tooyama, I. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.035 · Cited by 18

Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry

Wengler, K., Trujillo, P., Cassidy, C., & Horga, G. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01934-y · Cited by 18

A dual-signal sensing platform based on single atomic iron-nitrogen-carbon nanozyme for the detection of neurodegenerative disease-related bioactive molecules acetylcholinesterase and dopamine

Han, Z., Zhou, C., Lv, Y., Wang, N., & Su, X. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.136969 · Cited by 17

Brain–Barrier Regulation, Metal (Cu, Fe) Dyshomeostasis, and Neurodegenerative Disorders in Man and Animals

Haywood, S. (2019) · Inorganics · doi:10.3390/inorganics7090108 · Cited by 17

Molecular mechanism of the unusual biphasic effects of the natural compound hinokitiol on iron-induced cellular DNA damage

Qin, M., Shao, B., Li, L., Zhang, Z., Sheng, Z.-G., Qin, L., Shao, J., & Zhu, B. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.042 · Cited by 17

Anti-Browning Effect of 2-Mercaptobenzo[d]imidazole Analogs with Antioxidant Activity on Freshly-Cut Apple Slices and Their Highly Potent Tyrosinase Inhibitory Activity

Lee, J., Park, H. S., Jung, H. J., Park, Y. J., Kang, M. K., Kim, H. J., Yoon, D., Ullah, S., Kang, D., Park, Y., et al. (2023) · Antioxidants · doi:10.3390/antiox12101814 · Cited by 17

Hypoxia and its Emerging Therapeutics in Neurodegenerative, Inflammatory and Renal Diseases

Bhatia, D., Ardekani, M. S., Shi, Q., & Movafagh, S. (2017) · Hypoxia and Human Diseases · doi:10.5772/66089 · Cited by 17

Association of exposure to manganese and iron with relaxation rates R1 and R2*- magnetic resonance imaging results from the WELDOX II study

Pesch, B., Dydak, U., Lotz, A., Casjens, S., Quetscher, C., Lehnert, M., Abramowski, J., Stewig, C., Yeh, C., Weiß, T., et al. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.08.008 · Cited by 17

Effectiveness of Fragment C Domain of Tetanus Toxin and Pramipexole in an Animal Model of Parkinson’s Disease

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Alpha-mangostin attenuates the apoptotic pathway of abamectin in the fetal rats’ brain by targeting pro-oxidant stimulus, catecholaminergic neurotransmitters, and transcriptional regulation of reelin and nestin

Ibrahim, K. A., Eleyan, M., Khwanes, S. A., Mohamed, R. A., & Ayesh, B. M. (2021) · Drug and Chemical Toxicology · doi:10.1080/01480545.2021.1960856 · Cited by 19

Neuroimaging Correlates of Substantia Nigra Hyperechogenicity in Parkinson’s Disease

Prasuhn, J., Strautz, R., Lemmer, F., Dreischmeier, S., Kasten, M., Hanssen, H., Heldmann, M., & Brüggemann, N. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-213000 · Cited by 17

Targeting Iron Dyshomeostasis for Treatment of Neurodegenerative Disorders

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Age-related differences in locus coeruleus intensity across a demographically diverse sample

Riley, E., Cicero, N. G., Mabry, S. A., Swallow, K. M., Anderson, A. K., & Rosa, E. D. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.03.005 · Cited by 16

Iron accumulation in the oculomotor nerve of the progressive supranuclear palsy brain

Lee, H., Lee, M. J., Kim, E., Huh, G. Y., Lee, J., & Cho, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-82469-w · Cited by 16

Quantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis

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On the Role of Iron in Idiopathic Parkinson’s Disease

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Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson’s disease

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Linking Mitochondrial Dysfunction, Neurotransmitter, and Neural Network Abnormalities and Mania: Elucidating Neurobiological Mechanisms of the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder

Freyberg, Z., Andreazza, A. C., McClung, C. A., & Phillips, M. L. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.07.011 · Cited by 20

Ferroptosis—A Shared Mechanism for Parkinson’s Disease and Type 2 Diabetes

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Neurotoxins as Preclinical Models for Parkinson’s Disease

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Aggravated behavioral and neurochemical deficits and redox imbalance in mice with enhanced neonatal iron intake: improvement by biochanin A and role of microglial p38 activation

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Improvement of non-motor and motor behavioral alterations associated with Parkinson-like disease in Drosophila melanogaster: Comparative effects of treatments with hesperidin and L-dopa

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Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets

Gao, X., Ding, J.-E., Xie, J., & Xu, H. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01499-6 · Cited by 16

Current Nondopaminergic Therapeutic Options for Motor Symptoms of Parkinson's Disease

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Potentialities of IGF-1 for regulating oxidative stress in neuroinflammation and neurodegeneration: theoretical review

Herrera, M. L., Champarini, L. G., Oliveros, A. L., Bellini, M. J., & Hereñú, C. B. (2024) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2024.00093 · Cited by 15

Controlled Synthesis and Characterization of Micrometric Single Crystalline Magnetite With Superparamagnetic Behavior and Cytocompatibility/Cytotoxicity Assessments

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Short-echo-time magnitude image derived from quantitative susceptibility mapping could resemble neuromelanin-sensitive MRI image in substantia nigra

Liu, X. L., Yang, L., Liu, F. T., Wu, P., Zhang, Y., Zhuang, H., Shi, Y., Wang, J., Geng, D. Y., & Li, Y. X. (2020) · BMC Neurology · doi:10.1186/s12883-020-01828-8 · Cited by 15

Pontine Arteriolosclerosis and Locus Coeruleus Oxidative Stress Differentiate Resilience from Mild Cognitive Impairment in a Clinical Pathologic Cohort

Kelly, S. C., Nelson, P. T., & Counts, S. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab017 · Cited by 15

High‐Density Optophysiology Platform for Recording Intracellular and Extracellular Signals across the Brain of Free‐Moving Animals

Zhang, S., Liu, Z., Zhang, Z., Wang, W.-K., & Tian, Y. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202301382 · Cited by 15

Overexpression of Vesicular Monoamine Transporter-2 may Block Neurotoxic Metabolites from Cytosolic Dopamine: a Potential Neuroprotective Therapy for Parkinson's Disease.

Segura-Aguilar, Sulzer, D., Zucca, F. A., & Zecca, L. (2019) · PubMed · Cited by 15

Melanins in Vertebrates

Wakamatsu, K., & Ito, S. (2021) · Springer eBooks · doi:10.1007/978-981-16-1490-3_2 · Cited by 14

The role of low subcortical iron, white matter myelin, and oligodendrocytes in schizophrenia: a quantitative susceptibility mapping and diffusion tensor imaging study

Vano, L. J., McCutcheon, R. A., Sedlacik, J., Rutigliano, G., Kaar, S. J., Finelli, V., Lobo, M. C., Berry, A., Statton, B. K., Fazlollahi, A., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03195-7 · Cited by 14

From pathogenesis to treatment: the emerging role of ferroptosis in Parkinson’s disease

Tu, R., Han, Z., Zhang, H., Jia, X., Sun, T., Liu, H., Li, J., Tang, M., & Wang, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1709561 · Cited by 15

Fronto-striato-thalamic circuit connectivity and neuromelanin in schizophrenia: an fMRI and neuromelanin-MRI study

Choi, S., Kim, M., Kim, T., Choi, E., Lee, J., Moon, S., Cho, S. S., Lee, J., & Kwon, J. S. (2023) · Schizophrenia · doi:10.1038/s41537-023-00410-8 · Cited by 14

Dopamine‑iron homeostasis interaction rescues mitochondrial fitness in Parkinson's disease

Buoso, C., Seifert, M., Lang, M., Griffith, C. M., Andújar, B. T., Rueda, M. P. C., Fischer, C., Doerrier, C., Talasz, H., Zanon, A., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106506 · Cited by 16

Caffeic Acid Phenyl Ester (CAPE) Protects against Iron-Mediated Cellular DNA Damage through Its Strong Iron-Binding Ability and High Lipophilicity

Shao, B., Mao, L., Tang, M., Yan, Z.-Y., Shao, J., Huang, C., Sheng, Z.-G., & Zhu, B. (2021) · Antioxidants · doi:10.3390/antiox10050798 · Cited by 14

Surface Plasmon Resonance Identifies High-Affinity Binding of l -DOPA to Siderocalin/Lipocalin-2 through Iron–Siderophore Action: Implications for Parkinson’s Disease Treatment

Alhassen, S., Şenel, M., & Alachkar, A. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00693 · Cited by 14

Behavior and gene expression in the brain of adult self-fertilizing mangrove rivulus fish (Kryptolebias marmoratus) after early life exposure to the neurotoxin β-N-methylamino-l-alanine (BMAA)

Carion, A., Markey, A., Hétru, J., Carpentier, C., Suárez-Ulloa, V., Denoël, M., Earley, R. L., & Silvestre, F. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.04.007 · Cited by 14

Proton Magnetic Resonance Spectroscopy for the Early Diagnosis of Parkinson Disease in the Substantia Nigra and Globus Pallidus: A Meta-Analysis With Trial Sequential Analysis

Gu, W., He, C., Chen, J., & Li, J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.838230 · Cited by 13

Relevance of tissue-resident memory CD8 T cells in the onset of Parkinson’s disease and examination of its possible etiologies: infectious or autoimmune?

de Fàbregues, O., Sellés, M. C., Ramos-Vicente, D., Roch, G., Vila, M., & Bové, J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106308 · Cited by 12

Alterations in subcortical magnetic susceptibility and disease-specific relationship with brain volume in major depressive disorder and schizophrenia

Shibukawa, S., Kan, H., Honda, S., Wada, M., Tarumi, R., Tsugawa, S., Tobari, Y., Maikusa, N., Mimura, M., Uchida, H., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02862-7 · Cited by 13

Quantitative susceptibility mapping of multiple system atrophy and Parkinson's disease correlates with neurotransmitter reference maps

Yan, S., Lu, J., Duan, B., Zhu, H., Liu, D., Li, L., Qin, Y., Li, Y., & Zhu, W. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106549 · Cited by 13

Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology

Currim, F., Tanwar, R., Brown-Leung, J. M., Paranjape, N., Liu, J., Sanders, L. H., Doorn, J. A., & Cannon, J. R. (2024) · NeuroToxicology · doi:10.1016/j.neuro.2024.06.016 · Cited by 14

Visualizing alpha‐synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo

Straumann, N., Combes, B. F., Deán‐Ben, X. L., Sternke‐Hoffmann, R., Gerez, J., Dias, I., Chen, Z., Watts, B., Rostami, I., Shi, K., et al. (2024) · Brain Pathology · doi:10.1111/bpa.13288 · Cited by 13

Deferoxamine alleviates chondrocyte senescence and osteoarthritis progression by maintaining iron homeostasis

Guo, Z., Lin, Y., Liu, H., Guo, J., Hou, L., Zhang, X., Xu, J., Ruan, Z., Li, M., Sun, K., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112619 · Cited by 13

Research Progress on the Relationship between Parkinson's Disease and REM Sleep Behavior Disorder

Zhou, Y., Liu, X., & Xu, B. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2309166 · Cited by 13

Determination of Dopamine Using 2-(4-Boronophenyl)quinoline-4-carboxylic Acids as Fluorescent Probes

Wang, H., Fang, G., Wang, K., Wu, Z., & Yao, Q. (2018) · Analytical Letters · doi:10.1080/00032719.2018.1488258 · Cited by 13

The influence of iron on selected properties of synthetic pheomelanin

Żądło, A. C., Mokrzynski, K. T., Ito, S., Wakamatsu, K., & Sarna, T. (2020) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-020-00918-1 · Cited by 13

Effective R2 relaxation rate, derived from dual-contrast fast-spin-echo MRI, enables detection of hemisphere differences in iron level and dopamine function in Parkinson’s disease and healthy individuals

Luo, J., & Collingwood, J. F. (2022) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2022.109708 · Cited by 13

A Prospective Study on the Relationship between Iron Supplement Intake, Hemoglobin Concentration, and Risk of Parkinsonism

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Iron- and Neuromelanin-Weighted Neuroimaging to Study Mitochondrial Dysfunction in Patients with Parkinson’s Disease

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