Zecca, Luigi

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 4,110

The role of iron in brain ageing and neurodegenerative disorders

Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology

Neurological diseases and metabolismIron Metabolism and Disorders

Cited by 1,819

Iron, brain ageing and neurodegenerative disorders

Zecca, L., Youdim, M. B. H., Riederer, P., Connor, J. R., & Crichton, R. R. (2004) · Nature Reviews Neuroscience

Neurological diseases and metabolismIron Metabolism and Disorders

Cited by 1,801

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

Zucca, F. A., Segura-Aguilar, J., Ferrari, E., Muñoz, P., Paris, I., Sulzer, D., Sarna, T., Casella, L., & Zecca, L. (2017) · Progress in Neurobiology

Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolism

Cited by 659

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

Zecca, L., Stroppolo, A., Gatti, A., Tampellini, D., Toscani, M., Gallorini, M., Giaveri, G., Arosio, P., Santambrogio, P., Fariello, R. G., et al. (2004) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolism

Cited by 495

Iron, Neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

Zecca, L., Gallorini, M., Schünemann, V., Trautwein, A. X., Gerlach, M., Riederer, P., Vezzoni, P., & Tampellini, D. (2001) · Journal of Neurochemistry

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 401

Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism

Barichella, M., Severgnini, M., Cilia, R., Cassani, E., Bolliri, C., Caronni, S., Ferri, V., Cancello, R., Ceccarani, C., Faierman, S., et al. (2019) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsGut microbiota and health

Cited by 393

Brain iron pathways and their relevance to Parkinson's disease

Berg, D., Gerlach, M., Youdim, M. B. H., Double, K. L., Zecca, L., Riederer, P., & Becker, G. (2001) · Journal of Neurochemistry

Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolism

Cited by 362

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

Cebrián, C., Zucca, F. A., Mauri, P., Steinbeck, J. A., Studer, L., Scherzer, C. R., Kanter, E., Budhu, S., Mandelbaum, J., Vonsattel, J. P., et al. (2014) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 338

Intraneuronal dopamine-quinone synthesis: a review

Sulzer, D., & Zecca, L. (1999) · Neurotoxicity Research

Parkinson's Disease Mechanisms and TreatmentsCoenzyme Q10 studies and effects

Cited by 284

Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson’s Disease

Zhang, W., Phillips, K., Wielgus, A. R., Liu, J., Albertini, A., Zucca, F. A., Faust, R., Qian, S. Y., Miller, D. S., Chignell, C. F., et al. (2011) · Neurotoxicity Research

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 257

Neuromelanin of the Human Substantia Nigra: An Update

Zucca, F. A., Basso, E., Cupaioli, F. A., Ferrari, E., Sulzer, D., Casella, L., & Zecca, L. (2014) · Neurotoxicity Research

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 243

New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

Zecca, L., Bellei, C., Costi, P., Albertini, A., Monzani, E., Casella, L., Gallorini, M., Bergamaschi, L., Moscatelli, A., Turro, N. J., et al. (2008) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and Treatmentsmelanin and skin pigmentation

Cited by 240

In vivo detection of iron and Neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage

Zecca, L., Berg, D., Arzberger, T., Ruprecht, P., Rausch, W. D., Musicco, M., Tampellini, D., Riederer, P., Gerlach, M., & Becker, G. (2005) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolism

Cited by 214

Iron, myelin, and the brain: neuroimaging meets neurobiology

Möller, H. E., Bossoni, L., Connor, J. R., Crichton, R. R., Does, M. D., Ward, R. J., Zecca, L., Zucca, F. A., & Ronen, I. (2019) · Trends in Neurosciences

Advanced MRI Techniques and ApplicationsNeurological diseases and metabolism

Cited by 207

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

Zecca, L., Wilms, H., Geick, S., Claasen, J.-H., Brandenburg, L.-O., Holzknecht, C., Panizza, M. L., Zucca, F. A., Deuschl, G., Sievers, J., et al. (2008) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 205

Engineered nanoparticles, How brain friendly is this new guest?

Cupaioli, F. A., Zucca, F. A., Boraschi, D., & Zecca, L. (2014) · Progress in Neurobiology

Nanoparticles: synthesis and applicationsNanoparticle-Based Drug Delivery

Cited by 139

Influence of neuromelanin on oxidative pathways within the human substantia nigra

Double, K. L., Ben-Shachar, D., Youdim, M. B. H., Zecca, L., Riederer, P., & Gerlach, M. (2002) · Neurotoxicology and Teratology

Parkinson's Disease Mechanisms and Treatmentsmelanin and skin pigmentation

Cited by 102

Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus

Wakamatsu, K., Tabuchi, K., Ojika, M., Zucca, F. A., Zecca, L., & Ito, S. (2015) · Journal of Neurochemistry

melanin and skin pigmentationParkinson's Disease Mechanisms and Treatments

Cited by 76

Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role

Zucca, F. A., Capucciati, A., Bellei, C., Sarna, M., Sarna, T., Monzani, E., Casella, L., & Zecca, L. (2023) · IUBMB Life

Parkinson's Disease Mechanisms and Treatmentsmelanin and skin pigmentation

Cited by 69

Interaction of Neuromelanin with Xenobiotics and Consequences for Neurodegeneration; Promising Experimental Models

Capucciati, A., Zucca, F. A., Monzani, E., Zecca, L., Casella, L., & Hofer, T. (2021) · Antioxidants

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 36

Changes in nitric oxide metabolite levels in stimulated substantia nigra neurons

Zecca, L., Fariello, R. G., Galimberti, M., Racagni, G., & Ambrosini, A. (1997) · NeuroReport

Nitric Oxide and Endothelin EffectsNeuroscience and Neuropharmacology Research

Cited by 11