Stimulant Abuse: Pharmacology, Cocaine, Methamphetamine, Treatment, Attempts at Pharmacotherapy
Open accessAbstract
The high prevalence of stimulant abuse and its harmful consequences make the screening, diagnosis, and referral for treatment of persons with stimulant abuse a top concern for primary care providers. Having a working knowledge of use patterns, clinical symptomatology, end-organ effects, and advances in treatment of stimulant abuse is essential. Although cocaine and amphetamine have different use patterns, duration of action, and so forth, the consequences of use are remarkably similar. Primary care is at the forefront of screening, brief risk reduction interventions, and diagnosis of medical sequelae, with referral to addiction specialist treatment when necessary.
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Injection stimulant use increases the risk of infectious diseases, including HIV and viral hepatitis, and other infectious complications such as infective endocarditis.
“Further, injection stimulant use puts people at risk for infectious diseases, including human immunodeficiency virus (HIV) and viral hepatitis, as well as other infectious complications such as infective endocarditis.11”
From The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder (2024) · cites this paper as [11]
The Clinical features > HIV section (page unavailable) states that injection and needle sharing increase HIV transmission risk and that injection risk behaviors increase transmission risk for HCV and HBV. The available passages do not mention infective endocarditis; searches for that term and for bacterial infection found no supporting passage. (LLM, conf=0.88)
Experimental — accuracy not yet measuredStimulant use disorder can cause serious long-term health problems, including cardiac, pulmonary, psychiatric, dental, nutritional, and dermatologic issues, as well as cognitive impairment.
“Beyond the mortality risk, StUD can also lead to long-term health problems, including cardiac, pulmonary, psychiatric, dental, nutritional, and dermatologic issues, as well as cognitive impairment.11”
From The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder (2024) · cites this paper as [11]
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“However, most of these studies have been limited to small clinical trials, and there are currently non-FDA-approved medications to treat cocaine or methamphetamine addiction [4,35].”
BackgroundCook, J., Lloyd-Jones, M., Arunogiri, S., Ogden, E., & Bonomo, Y. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867417714878 · Cited by 13 · see citing works
- Authors
- Ciccarone, D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Ciccarone, Daniel
- ORCID
- Ciccarone, Daniel
- Venue
- Primary Care: Clinics in Office Practice
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 38
- Issue
- 1
- Pages
- 41-58
- ISSN
- 0095-4543 (ISSN-L)
- PMC
- PMC3056348
- OpenAlex
- W2154960645
- Cited by
- 200
- References
- 9
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 15 · 2023: 19 · 2022: 22 · 2021: 18 · 2020: 19 · 2019: 9 · 2018: 19 · 2017: 8 · 2016: 13 · 2015: 9 · 2014: 11 · 2013: 9 · 2012: 11
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Primary Care Clinics in Office Practice (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- stimulant abuse, cocaine, methamphetamine, pharmacology, pharmacotherapy, addiction treatment, screening, primary care, substance use disorders
- MeSH terms
- Amphetamine, Central Nervous System Stimulants, Cocaine, Humans, Methamphetamine, Primary Health Care, United States, HIV Infections, Dopamine Uptake Inhibitors, Substance-Related Disorders, Amphetamine-Related Disorders, Cocaine-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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