The DOI matches its Crossref record; 215 of the 232 references it cites were found in a registry or an index.
Retinal stimulation strategies to restore vision: Fundamentals and systems
Open accessAbstract
Retinal degeneration, a leading cause of blindness worldwide, is primarily characterized by the dysfunctional/degenerated photoreceptors that impair the ability of the retina to detect light. Our group and others have shown that bioelectronic retinal implants restore useful visual input to those who have been blind for decades. This unprecedented approach of restoring sight demonstrates that patients can adapt to new visual input, and thereby opens up opportunities to not only improve this technology but also develop alternative retinal stimulation approaches. These future improvements or new technologies could have the potential of selectively stimulating specific cell classes in the inner retina, leading to improved visual resolution and color vision. In this review we will detail the progress of bioelectronic retinal implants and future devices in this genre as well as discuss other technologies such as optogenetics, chemical photoswitches, and ultrasound stimulation. We will discuss the principles, biological aspects, technology development, current status, clinical outcomes/prospects, and challenges for each approach. The review will cover functional imaging documented cortical responses to retinal stimulation in blind patients.
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“Subretinal prostheses are typically small in size, since large subretinal implants might encounter considerable difficulty in the surgical placement and represent a high risk of retinal detachment [32].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [32]
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Metadata
- Authors
- Yue, L., Weiland, J. D., Roska, B., & Humayun, M. S.
- Affiliations
- University of Southern California (US)
- University of Basel (CH)
- Corresponding author
- Humayun, Mark S.
- Venue
- Progress in Retinal and Eye Research
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 53
- Pages
- 21-47
- ISSN
- 1350-9462 (ISSN-L)
- OpenAlex
- W2401981424
- Cited by
- 272
- References
- 232
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 28 · 2023: 19 · 2022: 30 · 2021: 35 · 2020: 43 · 2019: 31 · 2018: 22 · 2017: 26 · 2016: 4
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Progress in Retinal and Eye Research (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- W. M. Keck Foundation
- National Science Foundation (NSF) (CBET-1404089)
- Juliette RP Vision Foundation
- Guangdong Innovative and Entrepreneurial and Research Team Program (2013S046)
- Shenzhen Peacock Plan of China
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- retinal stimulation, retinal degeneration, blindness, photoreceptor degeneration, optogenetics, ultrasound stimulation, vision restoration, color vision, visual resolution
- MeSH terms
- Animals, Energy Metabolism, Humans, Retina, Retinal Degeneration, Vision, Ocular, Recovery of Function, Visual Prosthesis, Optogenetics
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