Retinal stimulation strategies to restore vision: Fundamentals and systems

Retinitis pigmentosa

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Prevalence of Age-Related Macular Degeneration in the United States

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Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration

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Independent optical excitation of distinct neural populations

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Neural Stimulation and Recording Electrodes

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Electrical stimulation of excitable tissue: design of efficacious and safe protocols

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Azobenzene photoswitches for biomolecules

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Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

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The sensations produced by electrical stimulation of the visual cortex

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Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

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Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives

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Microbial Rhodopsins: Diversity, Mechanisms, and Optogenetic Applications

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Neuroprotective strategies for retinal disease

Pardue, M. T., & Allen, R. S. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.02.002 · Cited by 237

Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities

Schneider, N., Sundaresan, Y., Gopalakrishnan, P., Beryozkin, A., Hanany, M., Levanon, E. Y., Banin, E., Ben‐Aroya, S., & Sharon, D. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101029 · Cited by 231

An update on retinal prostheses

Ayton, L. N., Barnes, N., Dagnelie, G., Fujikado, T., Goetz, G., Hornig, R., Jones, B. W., Muqit, M. M. K., Rathbun, D. L., Stingl, K., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.11.029 · Cited by 223

Early and late stage gene therapy interventions for inherited retinal degenerations

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Cell types and cell circuits in human and non-human primate retina

Grünert, U., & Martin, P. R. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100844 · Cited by 196

Persistent remodeling and neurodegeneration in late-stage retinal degeneration

Pfeiffer, R. L., Marc, R. E., & Jones, B. W. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.07.004 · Cited by 184

Retinitis Pigmentosa: Progress in Molecular Pathology and Biotherapeutical Strategies

Liu, W., Liu, S., Li, P., & Yao, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094883 · Cited by 192

Organic Bioelectronics: Materials and Biocompatibility

Feron, K., Lim, R., Sherwood, C. P., Keynes, A., Brichta, A. M., & Dastoor, P. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082382 · Cited by 177

Cilia - The sensory antennae in the eye

May‐Simera, H., Nagel‐Wolfrum, K., & Wolfrum, U. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.05.001 · Cited by 166

Restoring vision

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The X-linked retinopathies: Physiological insights, pathogenic mechanisms, phenotypic features and novel therapies

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Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses

Jiang, L., Lu, G., Zeng, Y., Sun, Y., Kang, H., Burford, J. L., Gong, C., Humayun, M. S., Chen, Y., & Zhou, Q. (2022) · Nature Communications · doi:10.1038/s41467-022-31599-4 · Cited by 154

Photoreceptor cell replacement in macular degeneration and retinitis pigmentosa: A pluripotent stem cell-based approach

Gagliardi, G., M’Barek, K. B., & Goureau, O. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.03.001 · Cited by 145

Natural History of the Central Structural Abnormalities in Choroideremia

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Optogenetic approaches to vision restoration

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Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas

Chenais, N. A. L., Airaghi Leccardi, M. J. I., & Ghezzi, D. (2021) · Communications Materials · doi:10.1038/s43246-021-00133-2 · Cited by 110

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Zeng, Q., & Huang, Z. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202301223 · Cited by 104

How Azobenzene Photoswitches Restore Visual Responses to the Blind Retina

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Leveraging Zebrafish to Study Retinal Degenerations

Angueyra, J. M., & Kindt, K. S. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00110 · Cited by 85

On the use of Parylene C polymer as substrate for peripheral nerve electrodes

de la Oliva, N., Mueller, M. C., Stieglitz, T., Navarro, X., & del Valle, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-24502-z · Cited by 82

Molecular Therapies for Inherited Retinal Diseases—Current Standing, Opportunities and Challenges

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Leber congenital amaurosis/early-onset severe retinal dystrophy: current management and clinical trials

Varela, M. D., de Guimarães, T. A. C., Georgiou, M., & Michaelides, M. (2021) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2020-318483 · Cited by 74

Self‐Unfolding Flexible Microelectrode Arrays Based on Shape Memory Polymers

Wang, J., Zhao, Q., Wang, Y., Zeng, Q., Wu, T., & Du, X. (2019) · Advanced Materials Technologies · doi:10.1002/admt.201900566 · Cited by 73

Smart Contact Lenses with a Transparent Silver Nanowire Strain Sensor for Continuous Intraocular Pressure Monitoring

Kim, T. Y., Shin, S., Choi, H., Jeong, S. H., Myung, D. J., & Hahn, S. K. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00267 · Cited by 72

Simultaneous Assessment of the Whole Eye Biomechanics Using Ultrasonic Elastography

Li, R., Qian, X., Gong, C., Zhang, J., Liu, Y., Xu, B. Y., Humayun, M. S., & Zhou, Q. (2022) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2022.3215498 · Cited by 68

Gene Therapy in Inherited Retinal Diseases: An Update on Current State of the Art

Amato, A., Arrigo, A., Aragona, E., Manitto, M. P., Saladino, A., Bandello, F. M., & Parodi, M. B. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.750586 · Cited by 68

Optogenetics for visual restoration: From proof of principle to translational challenges

Lindner, M., Gilhooley, M. J., Hughes, S., & Hankins, M. W. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101089 · Cited by 68

Electrodeposited Iridium Oxide on Platinum Nanocones for Improving Neural Stimulation Microelectrodes

Zeng, Q., Xia, K., Sun, B., Yin, Y., Wu, T., & Humayun, M. S. (2017) · Electrochimica Acta · doi:10.1016/j.electacta.2017.03.213 · Cited by 65

A Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis: Interim Clinical Trial Results

Petoe, M. A., Titchener, S. A., Kolic, M., Kentler, W. G., Abbott, C. J., Nayagam, D. A. X., Baglin, E. K., Kvansakul, J., Barnes, N., Walker, J. G., et al. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.10.12 · Cited by 63

Spatiotemporal characteristics of retinal response to network-mediated photovoltaic stimulation

Ho, E., Smith, R., Goetz, G., Lei, X., Galambos, L., Kamins, T. I., Harris, J. S., Mathieson, K., Palanker, D., & Sher, A. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00872.2016 · Cited by 57

Image processing strategies based on saliency segmentation for object recognition under simulated prosthetic vision

Li, H., Su, X., Wang, J., Kan, H., Han, T., Zeng, Y., & Chai, X. (2018) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2017.11.001 · Cited by 59

Tissue‐Like Optoelectronic Neural Interface Enabled by PEDOT:PSS Hydrogel for Cardiac and Neural Stimulation

Han, M., Yıldız, E., Kaleli, H. N., Karaz, S., Eren, G. O., Dogru-Yuksel, I. B., Şenses, E., Şahin, A., & Nizamoğlu, S. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202102160 · Cited by 59

Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement

Chan, H. H., Lam, C. H.-I., Choi, K. Y., Li, S. Z.-C., Lakshmanan, Y., Yu, W. Y., Chang, R. C., Lai, J. S. M., & So, K. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.03.023 · Cited by 59

Reconstruction of natural visual scenes from neural spikes with deep neural networks

Zhang, Y., Jia, S., Zheng, Y., Yu, Z., Tian, Y., Ma, S., Huang, T., & Liu, J. K. (2020) · Neural Networks · doi:10.1016/j.neunet.2020.01.033 · Cited by 61

Restoring visual function to the blind retina with a potent, safe and long-lasting photoswitch

Tochitsky, I., Trautman, J. K., Gallerani, N., Malis, J. G., & Krämer, R. (2017) · Scientific Reports · doi:10.1038/srep45487 · Cited by 58

Bioinspired Underwater Propulsors

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Stargardt disease and progress in therapeutic strategies

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Co-grafts of Human Embryonic Stem Cell Derived Retina Organoids and Retinal Pigment Epithelium for Retinal Reconstruction in Immunodeficient Retinal Degenerate Royal College of Surgeons Rats

Thomas, B. B., Lin, B., Martinez-Camarillo, J. C., Zhu, D., McLelland, B. T., Nistor, G., Keirstead, H. S., Humayun, M. S., & Seiler, M. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.752958 · Cited by 53

Conductive Polymer Enabled Biostable Liquid Metal Electrodes for Bioelectronic Applications

Lim, T., Kim, M., Akbarian, A., Kim, J., Tresco, P. A., & Zhang, H. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102382 · Cited by 53

Lycium Barbarum Polysaccharides Protect Retina in rd1 Mice During Photoreceptor Degeneration

Liu, F., Zhang, J., Xiang, Z., Xu, D., So, K., Vardi, N., & Xu, Y. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22881 · Cited by 53

Stimulation strategies for selective activation of retinal ganglion cell soma and threshold reduction

Chang, Y.-C., Ghaffari, D. H., Chow, R. H.-P., & Weiland, J. D. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aaf92b · Cited by 54

Shape-adaptable biodevices for wearable and implantable applications

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Molecular Mechanisms Mediating Diabetic Retinal Neurodegeneration: Potential Research Avenues and Therapeutic Targets

Chakravarthy, H., & Devanathan, V. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1188-x · Cited by 46

Advances in visual prostheses: engineering and biological challenges

Borda, E., & Ghezzi, D. (2022) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ac812c · Cited by 44

Oxygen vacancy healing boosts the piezoelectricity of bone scaffolds

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Nature inspired nanomaterials, advancements in green synthesis for biological sustainability

Rasool, A., Sri, S., Zulfajri, M., & Krismastuti, F. S. H. (2024) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2024.112954 · Cited by 44

2D Semiconductor Based Flexible Photoresponsive Ring Oscillators for Artificial Vision Pixels

Li, N., Wang, Q., He, C., Li, J., Li, X., Shen, C., Huang, B., Tang, J., Yu, H., Wang, S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c06921 · Cited by 43

Laboratory and clinical reliability of conformally coated subretinal implants

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Reconciling Color Vision Models With Midget Ganglion Cell Receptive Fields

Patterson, S. S., Neitz, M., & Neitz, J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00865 · Cited by 45

Toward the Next Generation of Retinal Neuroprosthesis: Visual Computation with Spikes

Yu, Z., Liu, J. K., Jia, S., Zhang, Y., Zheng, Y., Tian, Y., & Huang, T. (2020) · Engineering · doi:10.1016/j.eng.2020.02.004 · Cited by 43

Neuromorphic computing for modeling neurological and psychiatric disorders: implications for drug development

Raikar, A. S., Andrew, J., Dessai, P. P., Prabhu, S. M., Jathar, S., Prabhu, A., Naik, M. B., & Raikar, G. V. S. (2024) · Artificial Intelligence Review · doi:10.1007/s10462-024-10948-3 · Cited by 40

Eye Movement Compensation and Spatial Updating in Visual Prosthetics: Mechanisms, Limitations and Future Directions

Paraskevoudi, N., & Pezaris, J. S. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00073 · Cited by 39

Organic Photovoltaic Sensors for Photocapacitive Stimulation of Voltage‐Gated Ion Channels in Neuroblastoma Cells

Abdullaeva, O. S., Balzer, F., Schulz, M., Parisi, J., Lützen, A., Dedek, K., & Schiek, M. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201805177 · Cited by 39

Restoring Color Perception to the Blind

Lan, Y., Castillo, J., Gonzalez-Calle, A., Neitz, J., & Humayun, M. S. (2020) · Ophthalmology · doi:10.1016/j.ophtha.2020.08.019 · Cited by 39

Nanocone-Array-Based Platinum-Iridium Oxide Neural Microelectrodes: Structure, Electrochemistry, Durability and Biocompatibility Study

Zeng, Q., Yu, S., Fan, Z., Huang, Y., Song, B., & Zhou, T. (2022) · Nanomaterials · doi:10.3390/nano12193445 · Cited by 35

Retinal cadherins and the retinal cadherinopathies: Current concepts and future directions

Yusuf, I. H., Garrett, A. M., MacLaren, R. E., & Issa, P. C. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101038 · Cited by 37

Impact of Photoreceptor Loss on Retinal Circuitry

Lee, J. Y., Care, R. A., Santina, L. D., & Dunn, F. A. (2021) · Annual Review of Vision Science · doi:10.1146/annurev-vision-100119-124713 · Cited by 43

Research progress of photo-crosslink hydrogels in ophthalmology: A comprehensive review focus on the applications

Zhang, Q., Yan, K., Zheng, X., Liu, Q., Han, Y., & Liu, Z. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101082 · Cited by 35

Tissue engineering of the retina: from organoids to microfluidic chips

Marcos, L. F., Wilson, S. L., & Roach, P. (2021) · Journal of Tissue Engineering · doi:10.1177/20417314211059876 · Cited by 33

Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients

Shim, S., Eom, K., Jeong, J., & Kim, S. J. (2020) · Micromachines · doi:10.3390/mi11050535 · Cited by 35

Implantation, removal and replacement of subretinal electronic implants for restoration of vision in patients with retinitis pigmentosa

Gekeler, K., Bartz‐Schmidt, K. U., Sachs, H. G., MacLaren, R. E., Štingl, K., Zrenner, E., & Gekeler, F. (2018) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000467 · Cited by 31

Micro/Nano Technologies for High-Density Retinal Implant

Zeng, Q., Zhao, S., Yang, H., Zhang, Y., & Wu, T. (2019) · Micromachines · doi:10.3390/mi10060419 · Cited by 32

Computational Modeling of Spatially Selective Retinal Stimulation With Temporally Interfering Electric Fields

Su, X., Guo, J., Zhou, M., Chen, J., Li, L., Chen, Y., Sui, X., Li, H., & Chai, X. (2021) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2021.3055203 · Cited by 29

Breaking genetic shackles: The advance of base editing in genetic disorder treatment

Xu, F., Zheng, C., Xu, W., Zhang, S., Liu, S., Chen, X., & Yao, K. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1364135 · Cited by 32

Photochemistry of Organic Retinal Prostheses

Manfredi, G., Colombo, E., Barsotti, J., Benfenati, F., & Lanzani, G. (2019) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-042018-052445 · Cited by 29

Gene therapy for inherited retinal degenerations: initial successes and future challenges

Gupta, P. R., & Huckfeldt, R. M. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa7a27 · Cited by 32

Capacitive-like photovoltaic epiretinal stimulation enhances and narrows the network-mediated activity of retinal ganglion cells by recruiting the lateral inhibitory network

Chenais, N. A. L., Leccardi, M. J. I. A., & Ghezzi, D. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab3913 · Cited by 24

The very large electrode array for retinal stimulation (VLARS)—A concept study

Lohmann, T., Haiss, F., Schaffrath, K., Schnitzler, A. C., Waschkowski, F., Barz, C. S., van der Meer, A.-M., Werner, C., Johnen, S., Laube, T., et al. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab4113 · Cited by 30

CRISPR/Cas9—A Promising Therapeutic Tool to Cure Blindness: Current Scenario and Future Prospects

Ahmad, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911482 · Cited by 30

A real-time image optimization strategy based on global saliency detection for artificial retinal prostheses

Li, H., Han, T., Wang, J., Lu, Z., Cao, X., Chen, Y., Li, L., Zhou, C., & Chai, X. (2017) · Information Sciences · doi:10.1016/j.ins.2017.06.014 · Cited by 27

A Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis: A Single-Arm Clinical Trial of Feasibility

Petoe, M. A., Abbott, C. J., Titchener, S. A., Kolic, M., Kentler, W. G., Nayagam, D. A. X., Baglin, E. K., Kvansakul, J. G. S., Barnes, N. M., Walker, J. G., et al. (2024) · Ophthalmology Science · doi:10.1016/j.xops.2024.100525 · Cited by 27

Stereochemical study of mouse muscone receptor MOR215-1 and vibrational theory based on statistical physics formalism

Khemis, I. B., Mechi, N., & Lamine, A. B. (2018) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2018.02.004 · Cited by 25

Fabrication and Evaluation of Cyclic Olefin Copolymer Based Implantable Neural Electrode

Baek, C., Kim, J. J., Lee, Y., & Seo, J.-M. (2020) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2020.2963992 · Cited by 25

Multi‐Factor Modulated Organic Bulk Heterojunction Synaptic Transistor Enabled by Ligand Engineering for Centrosymmetric In‐Sensor Computing

Li, E., Wang, X., Yu, X., Yu, R., Li, W., Guo, T., Chu, J., & Chen, H. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202314980 · Cited by 24

Fast Photoswitchable Molecular Prosthetics Control Neuronal Activity in the Cochlea

Garrido‐Charles, A., Huet, A. T., Matera, C., Thirumalai, A., Hernando, J. C., Llebaria, A., Moser, T., & Gorostiza, P. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.1c12314 · Cited by 24

Improved mobility performance with an artificial vision therapy system using a thermal sensor

He, Y., Sun, S. Y., Roy, A., Caspi, A., & Montezuma, S. R. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/aba4fb · Cited by 23

Enhanced electrochemical performance of neural electrodes based on PEDOT : PSS hydrogel

Zeng, Q., & Wu, T. (2021) · Journal of Applied Polymer Science · doi:10.1002/app.51804 · Cited by 23

Irregularly timed electrical pulses reduce adaptation of retinal ganglion cells

Soto-Breceda, A., Kameneva, T., Hamish Meffin, A., Maturana, M. I., & Ibbotson, M. R. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aad46e · Cited by 25

Emerging Trends of Biomedical Circuits and Systems

Sawan, M., Yang, J., Tarkhan, M., Chen, J., Wang, M., Wang, C., Xia, F., & Chen, Y.-H. (2021) · Foundations and Trends® in Integrated Circuits and Systems · doi:10.1561/3500000005 · Cited by 23

A Three-Dimensional Microelectrode Array to Generate Virtual Electrodes for Epiretinal Prosthesis Based on a Modeling Study

Lyu, Q., Lu, Z., Li, H., Qiu, S., Guo, J., Sui, X., Sun, P., Li, L., Chai, X., & Lovell, N. H. (2019) · International Journal of Neural Systems · doi:10.1142/s0129065720500069 · Cited by 22

Robust Decoding of Rich Dynamical Visual Scenes With Retinal Spikes

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Inhibition of non-NMDA ionotropic glutamate receptors delays the retinal degeneration in rd10 mouse

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Electrical stimulation of degenerate retina

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The Retina Implant New Approach to a Visual Prosthesis / Das Retina-Implant Ein neuer Ansatz für eine Sehprothese

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