Cited by 272Neuroscience and Neural EngineeringRetinal Development and DisordersTactile and Sensory Interactions

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Retinal stimulation strategies to restore vision: Fundamentals and systems

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Yue, Lan, Weiland, James D., Roska, Botond, Humayun, Mark S.·2016·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2016.05.002

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Abstract

Retinal degeneration, a leading cause of blindness worldwide, is primarily characterized by the dysfunctional/degenerated photoreceptors that impair the ability of the retina to detect light. Our group and others have shown that bioelectronic retinal implants restore useful visual input to those who have been blind for decades. This unprecedented approach of restoring sight demonstrates that patients can adapt to new visual input, and thereby opens up opportunities to not only improve this technology but also develop alternative retinal stimulation approaches. These future improvements or new technologies could have the potential of selectively stimulating specific cell classes in the inner retina, leading to improved visual resolution and color vision. In this review we will detail the progress of bioelectronic retinal implants and future devices in this genre as well as discuss other technologies such as optogenetics, chemical photoswitches, and ultrasound stimulation. We will discuss the principles, biological aspects, technology development, current status, clinical outcomes/prospects, and challenges for each approach. The review will cover functional imaging documented cortical responses to retinal stimulation in blind patients.

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Authors: Yue, L., Weiland, J. D., Roska, B., & Humayun, M. S.
Affiliations: University of Southern California (US)
University of Basel (CH)
Corresponding author: Humayun, Mark S.
ORCID: Weiland, James D.
Roska, Botond
Humayun, Mark S.
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2016-07
Volume: 53
Pages: 21-47
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2016.05.002
OpenAlex: W2401981424
Cited by: 272
References: 232
Citations by year: 2026: 12 · 2025: 22 · 2024: 28 · 2023: 19 · 2022: 30 · 2021: 35 · 2020: 43 · 2019: 31 · 2018: 22 · 2017: 26 · 2016: 4
FWCI: 3.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 352 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Progress in Retinal and Eye Research (acceptedVersion)
PubMed (publishedVersion)
Funders: W. M. Keck Foundation
National Science Foundation (NSF) (CBET-1404089)
Juliette RP Vision Foundation
Guangdong Innovative and Entrepreneurial and Research Team Program (2013S046)
Shenzhen Peacock Plan of China
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords: retinal stimulation, retinal degeneration, blindness, photoreceptor degeneration, optogenetics, ultrasound stimulation, vision restoration, color vision, visual resolution
MeSH terms: Animals, Energy Metabolism, Humans, Retina, Retinal Degeneration, Vision, Ocular, Recovery of Function, Visual Prosthesis, Optogenetics

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Retinal stimulation strategies to restore vision: Fundamentals and systems

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