The DOI matches its Crossref record; 394 of the 399 references it cites were found in a registry or an index.
On phagocytes and macular degeneration
Open accessAbstract
Age related macular degeneration (AMD) is a complex multifactorial disease caused by the interplay of age and genetic and environmental risk factors. A common feature observed in early and both forms of late AMD is the breakdown of the physiologically immunosuppressive subretinal environment and the protracted accumulation of mononuclear phagocytes (MP). We here discuss the origin and nature of subretinal MPs, the mechanisms that lead to their accumulation, the inflammatory mediators they produce as well as the consequences of their chronic presence on photoreceptors, retinal pigment epithelium and choroid. Recent advances highlight how both genetic and environmental risk factors directly promote subretinal inflammation and tip the balance from a beneficial inflammation that helps control debris accumulation to detrimental chronic inflammation and destructive late AMD. Finally, we discuss how changes in life style or pharmacological intervention can help to break the vicious cycle of inflammation and degeneration, restore the immunosuppressive properties of the subretinal space, and reestablish homeostasis.
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Microglia in Retinal Degeneration
Rashid, K., Akhtar‐Schäfer, I., & Langmann, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01975 · Cited by 365
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Self-citation
Metadata
- Authors
- Guillonneau, X., Eandi, C. M., Paques, M., Sahel, J.-A., Sapieha, P., & Sennlaub, F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Turin (IT)
- Hôpital Maisonneuve-Rosemont (CA)
- Corresponding author
- Sennlaub, Florian
- Venue
- Progress in Retinal and Eye Research
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 61
- Pages
- 98-128
- ISSN
- 1350-9462 (ISSN-L)
- OpenAlex
- W2622806731
- Cited by
- 185
- References
- 399
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 31 · 2023: 16 · 2022: 19 · 2021: 33 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 1
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Progress in Retinal and Eye Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- INSERM
- ANR Geno 2009 (R09099DS)
- ANR MACLEAR (ANR-15-CE14-0015-01)
- LABEX LIFESENSES (ANR-10-LABX-65)
- ANR (Investissements d'Avenir programme (ANR-11-IDEX-0004-02)
- Carnot
- ERC (ERC-2007 St.G. 210345)
- Association de Prévoyance Santé de ALLIANZ
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Keywords
- age-related macular degeneration, mononuclear phagocytes, chronic inflammation, retinal pigment epithelium, photoreceptors, choroid, genetic risk factors, environmental risk factors, immunosuppression, lifestyle modification
- MeSH terms
- Choroid, Humans, Life Style, Macular Degeneration, Macular Edema, Phagocytes, Photoreceptor Cells, Retinal Pigment Epithelium
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