Sahel, José-Alain

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., et al. (2016) · Nature Genetics

Retinal Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 1,544

Interim results from the international trial of Second Sight's visual prosthesis

Humayun, M. S., Dorn, J. D., da Cruz, L., Dagnelie, G., Sahel, J.-A., Stanga, P. E., Cideciyan, A. V., Duncan, J. L., Eliott, D., Filley, E., et al. (2012) · Ophthalmology

Neuroscience and Neural EngineeringRetinal Development and Disorders

Cited by 700

Partial recovery of visual function in a blind patient after optogenetic therapy

Sahel, J.-A., Boulanger-Scemama, E., Pagot, C., Arleo, A., Galluppi, F., Martel, J. N., Esposti, S. D., Delaux, A., de Saint Aubert, J.-B., de Montleau, C., et al. (2021) · Nature Medicine

Photoreceptor and optogenetics researchRetinal Development and Disorders

Cited by 700

Five-year safety and performance results from the argus II retinal prosthesis system clinical trial.

da Cruz, L., Dorn, J. D., Humayun, M. S., Dagnelie, G., Handa, J., Barale, P.-O., Sahel, J.-A., Stanga, P. E., Hafezi, F., Safran, A. B., et al. (2016) · Ophthalmology

Neuroscience and Neural EngineeringRetinal Development and Disorders

Cited by 359

Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy

Yu-Wai-Man, P., Newman, N. J., Carelli, V., Moster, M. L., Biousse, V., Sadun, A. A., Klopstock, T., Vignal-Clermont, C., Sergott, R. C., Rudolph, G., et al. (2020) · Science Translational Medicine

Retinal Development and DisordersVirus-based gene therapy research

Cited by 232

Emerging therapies for inherited retinal degeneration

Scholl, H. P. N., Strauss, R. W., Singh, M. S., Dalkara, D., Roska, B., Picaud, S., & Sahel, J.-A. (2016) · Science Translational Medicine

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 219

Early and late stage gene therapy interventions for inherited retinal degenerations

Botto, C., Rucli, M., Tekinsoy, M. D., Pulman, J., Sahel, J.-A., & Dalkara, D. (2022) · Progress in Retinal and Eye Research

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 190

On phagocytes and macular degeneration

Guillonneau, X., Eandi, C. M., Paques, M., Sahel, J.-A., Sapieha, P., & Sennlaub, F. (2017) · Progress in Retinal and Eye Research

Retinal Diseases and TreatmentsOcular Diseases and Behçet’s Syndrome

Cited by 185

Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation

Calippe, B., Augustin, S., Beguier, F., Charles-Messance, H., Poupel, L., Conart, J.-B., Hu, S. J., Lavalette, S., Fauvet, A., Rayes, J., et al. (2017) · Immunity

Phagocytosis and Immune RegulationComplement system in diseases

Cited by 168

Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset

Newman, N. J., Yu-Wai-Man, P., Carelli, V., Moster, M. L., Biousse, V., Vignal-Clermont, C., Sergott, R. C., Klopstock, T., Sadun, A. A., Barboni, P., et al. (2021) · Ophthalmology

Retinal Development and DisordersVirus-based gene therapy research

Cited by 168

Case-control study of the risk factors for age related macular degeneration

Chaine, G., Hullo, A., Sahel, J., Soubrane, G., Espinasse-Berrod, M.-A., Schutz, D., Bourguignon, C., Harpey, C., Brault, Y., Coste, M., et al. (1998) · British Journal of Ophthalmology

Retinal Diseases and TreatmentsRetinal Imaging and Analysis

Cited by 161

Restoring vision

Roska, B., & Sahel, J.-A. (2018) · Nature

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 161

Simultaneous perception of prosthetic and natural vision in AMD patients

Palanker, D., Le Mer, Y., Mohand-Said, S., & Sahel, J. A. (2022) · Nature Communications

Neuroscience and Neural EngineeringRetinal Diseases and Treatments

Cited by 140

The optimized allotopic expression of ND1 or ND4 genes restores respiratory chain complex I activity in fibroblasts harboring mutations in these genes

Bonnet, C., Augustin, S., Ellouze, S., Bénit, P., Bouaita, A., Rustin, P., Sahel, J.-A., & Corral-Debrinski, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 130

Noninvasive gene delivery to foveal cones for vision restoration

Khabou, H., Garita-Hernandez, M., Chaffiol, A., Reichman, S., Jaillard, C., Brazhnikova, E., Bertin, S., Forster, V., Desrosiers, M., Winckler, C., et al. (2018) · JCI Insight

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 124

Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene: A Secondary Analysis of a Phase 1/2 Clinical Trial

Bouquet, C., Vignal Clermont, C., Galy, A., Fitoussi, S., Blouin, L., Munk, M. R., Valero, S., Meunier, S., Katz, B., Sahel, J. A., et al. (2019) · JAMA Ophthalmology

Virus-based gene therapy researchOcular Diseases and Behçet’s Syndrome

Cited by 104

Safety of rAAV2/2-ND4 gene therapy for leber hereditary optic neuropathy

Vignal, C., Uretsky, S., Fitoussi, S., Galy, A., Blouin, L., Girmens, J.-F., Bidot, S., Thomasson, N., Bouquet, C., Valero, S., et al. (2018) · Ophthalmology

Virus-based gene therapy researchGlaucoma and retinal disorders

Cited by 99

Allotopic mRNA localization to the mitochondrial surface rescues respiratory chain defects in fibroblasts harboring mitochondrial DNA mutations affecting complex I or v subunits

Bonnet, C., Kaltimbacher, V., Ellouze, S., Augustin, S., Bénit, P., Forster, V., Rustin, P., Sahel, J.-A., & Corral-Debrinski, M. (2007) · Rejuvenation Research

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 98

The aging of the retina

Bonnel, S., Mohand-Said, S., & Sahel, J.-A. (2003) · Experimental Gerontology

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 89

The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination

Beguier, F., Housset, M., Roubeix, C., Augustin, S., Zagar, Y., Nous, C., Mathis, T., Eandi, C., Benchaboune, M., Drame-Maigné, A., et al. (2020) · Immunity

Retinal Diseases and TreatmentsPhagocytosis and Immune Regulation

Cited by 87

Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss

Cwerman-Thibault, H., Augustin, S., Lechauve, C., Ayache, J., Ellouze, S., Sahel, J.-A., & Corral-Debrinski, M. (2015) · Molecular Therapy - Methods & Clinical Development

Mitochondrial Function and PathologyRetinal Development and Disorders

Cited by 86

An analysis of observer-rated functional vision in patients implanted with the Argus II retinal prosthesis system at three years

Geruschat, D. R., Richards, T. P., Arditi, A., Cruz, L., Dagnelie, G., Dorn, J. D., Duncan, J. L., Ho, A. C., Olmos de koo, L. C., Sahel, J., et al. (2016) · Clinical and Experimental Optometry

Neuroscience and Neural EngineeringAssistive Technology in Communication and Mobility

Cited by 77

Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8

Khabou, H., Desrosiers, M., Winckler, C., Fouquet, S., Auregan, G., Bemelmans, A., Sahel, J., & Dalkara, D. (2016) · Biotechnology and Bioengineering

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 71

Synthetic 3D diamond-based electrodes for flexible retinal neuroprostheses: model, production and in vivo biocompatibility

Bendali, A., Rousseau, L., Lissorgues, G., Scorsone, E., Djilas, M., Dégardin, J., Dubus, E., Fouquet, S., Benosman, R., Bergonzo, P., et al. (2015) · Biomaterials

Neuroscience and Neural EngineeringDiamond and Carbon-based Materials Research

Cited by 66