Cited by 187Retinal Diseases and TreatmentsOcular Diseases and Behçet’s SyndromeRetinal Development and Disorders

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On phagocytes and macular degeneration

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Guillonneau, Xavier, Eandi, Chiara M., Paques, Michel, Sahel, José-Alain, Sapieha, Przemyslaw, Sennlaub, Florian·2017·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2017.06.002

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Abstract

Age related macular degeneration (AMD) is a complex multifactorial disease caused by the interplay of age and genetic and environmental risk factors. A common feature observed in early and both forms of late AMD is the breakdown of the physiologically immunosuppressive subretinal environment and the protracted accumulation of mononuclear phagocytes (MP). We here discuss the origin and nature of subretinal MPs, the mechanisms that lead to their accumulation, the inflammatory mediators they produce as well as the consequences of their chronic presence on photoreceptors, retinal pigment epithelium and choroid. Recent advances highlight how both genetic and environmental risk factors directly promote subretinal inflammation and tip the balance from a beneficial inflammation that helps control debris accumulation to detrimental chronic inflammation and destructive late AMD. Finally, we discuss how changes in life style or pharmacological intervention can help to break the vicious cycle of inflammation and degeneration, restore the immunosuppressive properties of the subretinal space, and reestablish homeostasis.

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Authors: Guillonneau, X., Eandi, C. M., Paques, M., Sahel, J.-A., Sapieha, P., & Sennlaub, F.
Affiliations: Centre National de la Recherche Scientifique (FR)
University of Turin (IT)
Hôpital Maisonneuve-Rosemont (CA)
Corresponding author: Sennlaub, Florian
ORCID: Guillonneau, Xavier
Eandi, Chiara M.
Sahel, José-Alain
Sapieha, Przemyslaw
Sennlaub, Florian
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2017-11
Volume: 61
Pages: 98-128
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2017.06.002
OpenAlex: W2622806731
Cited by: 185
References: 399
Citations by year: 2026: 13 · 2025: 15 · 2024: 31 · 2023: 16 · 2022: 19 · 2021: 33 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 1
FWCI: 2.91
Type: journal article
Language: en
Open access: green
hal.sorbonne-universite.fr
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Retinal and Eye Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders: INSERM
ANR Geno 2009 (R09099DS)
ANR MACLEAR (ANR-15-CE14-0015-01)
LABEX LIFESENSES (ANR-10-LABX-65)
ANR (Investissements d'Avenir programme (ANR-11-IDEX-0004-02)
Carnot
ERC (ERC-2007 St.G. 210345)
Association de Prévoyance Santé de ALLIANZ
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Keywords: age-related macular degeneration, mononuclear phagocytes, chronic inflammation, retinal pigment epithelium, photoreceptors, choroid, genetic risk factors, environmental risk factors, immunosuppression, lifestyle modification
MeSH terms: Choroid, Humans, Life Style, Macular Degeneration, Macular Edema, Phagocytes, Photoreceptor Cells, Retinal Pigment Epithelium

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