Cited by 237Retinal Development and DisordersRetinal Diseases and TreatmentsGlaucoma and retinal disorders

The DOI matches its Crossref record; 412 of the 416 references it cites were found in a registry or an index.

Neuroprotective strategies for retinal disease

Open access

Pardue, Machelle T., Allen, Rachael S.·2018·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2018.02.002PMC PMC6081194

Open this paper in CoChat — free account Open PDF

Abstract

Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of sight affects patient quality of life and puts an economic burden both on individuals and the greater healthcare system. Despite the urgent need for treatments, few effective options currently exist in the clinic. Here, we review research on promising neuroprotective strategies that promote neuronal survival with the potential to protect against vision loss and retinal cell death. Due to the large number of neuroprotective strategies, we restricted our review to approaches that we had direct experience with in the laboratory. We focus on drugs that target survival pathways, including bile acids like UDCA and TUDCA, steroid hormones like progesterone, therapies that target retinal dopamine, and neurotrophic factors. In addition, we review rehabilitative methods that increase endogenous repair mechanisms, including exercise and electrical stimulation therapies. For each approach, we provide background on the neuroprotective strategy, including history of use in other diseases; describe potential mechanisms of action; review the body of research performed in the retina thus far, both in animals and in humans; and discuss considerations when translating each treatment to the clinic and to the retina, including which therapies show the most promise for each retinal disease. Despite the high incidence of retinal diseases and the complexity of mechanisms involved, several promising neuroprotective treatments provide hope to prevent blindness. We discuss attractive candidates here with the goal of furthering retinal research in critical areas to rapidly translate neuroprotective strategies into the clinic.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.preteyeres.2018.02.002

Cites

412 of 412 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Optical Coherence Tomography
Huang, D., Swanson, E. A., Lin, C. P., Schuman, J. S., Stinson, W. G., Chang, W., Hee, M. R., Flotte, T., Gregory, K. W., Puliafito, C. A., et al. (1991) · Science · doi:10.1126/science.1957169 · Cited by 14,001
Diabetic Retinopathy
Lang, G. E., Vaiser, A., Snyder, W. B., & Lynn, J. R. (2007) · Developments in ophthalmology · doi:10.1159/isbn.978-3-318-01439-6 · Cited by 5,607
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855
The Pathophysiology and Treatment of Glaucoma: A Review
Weinreb, R. N., Aung, T., & Medeiros, F. A. (2014) · JAMA · doi:10.1001/jama.2014.3192 · Cited by 4,210
Reduction of Intraocular Pressure and Glaucoma Progression
Heijl, A. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.10.1268 · Cited by 3,407
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures
(1998) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(98)00223-2 · Cited by 1,596
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80900-9 · Cited by 1,534
Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein
Lotharius, J., & Brundin, P. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn983 · Cited by 1,319

Flagged first, then by citations

Show all 416 references

4 of the 416 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Cidian, 2004, vol. 2
Obal, 1950, Klinische Monatsblatter fur Augenheilkunde und fur augenarztliche Fortbildung, Klin. Monbl. Augenheilkd Augenarztl Fortbild, 117, 201

Sorted by citations

Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives
Han, H., Li, S., Xu, M., Zhong, Y., Fan, W., Xu, J., Zhou, T., Ji, J., Ye, J., & Yao, K. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114770 · Cited by 341
Lipid nanoparticles for delivery of messenger RNA to the back of the eye
Patel, S., Ryals, R. C., Weller, K. K., Pennesi, M. E., & Sahay, G. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.015 · Cited by 260
Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities
Schneider, N., Sundaresan, Y., Gopalakrishnan, P., Beryozkin, A., Hanany, M., Levanon, E. Y., Banin, E., Ben‐Aroya, S., & Sharon, D. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101029 · Cited by 231
Immune responses to injury and their links to eye disease
Stepp, M. A., & Menko, A. S. (2021) · Translational research · doi:10.1016/j.trsl.2021.05.005 · Cited by 204
Treatments for dry age-related macular degeneration: therapeutic avenues, clinical trials and future directions
de Guimarães, T. A. C., Varela, M. D., Georgiou, M., & Michaelides, M. (2021) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2020-318452 · Cited by 197
Cell types and cell circuits in human and non-human primate retina
Grünert, U., & Martin, P. R. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100844 · Cited by 196
Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering
Friedrich, R. P., Cicha, I., & Alexiou, C. (2021) · Nanomaterials · doi:10.3390/nano11092337 · Cited by 158
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease
Avrutsky, M. I., & Troy, C. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.701301 · Cited by 151
Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions
Drag, S., Dotiwala, F., & Upadhyay, A. K. (2023) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.64.7.39 · Cited by 145
Role of Oxidative Stress in Retinal Disease and the Early Intervention Strategies: A Review
Wang, J., Li, M., Geng, Z., Khattak, S., Ji, X., Wu, D., & Dang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7836828 · Cited by 138
USH2A-retinopathy: From genetics to therapeutics
Toualbi, L., Toms, M., & Moosajee, M. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108330 · Cited by 105
Stem/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials
Wang, Y., Tang, Z., & Gu, P. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02955-3 · Cited by 99
Nanomedicine and drug delivery to the retina: current status and implications for gene therapy
Tawfik, M., Chen, F., Goldberg, J. L., & Sabel, B. A. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02287-3 · Cited by 96
Simultaneous co-delivery of neuroprotective drugs from multi-loaded PLGA microspheres for the treatment of glaucoma
Arranz-Romera, A., Davis, B. M., Bravo‐Osuna, I., Esteban-Pérez, S., Molina-Martínez, I. T., Shamsher, E., Ravindran, N., Guo, L., Cordeiro, M. F., & Herrero‐Vanrell, R. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.012 · Cited by 88
Müller cells as a target for retinal therapy
Devoldere, J., Peynshaert, K., Smedt, S. C. D., & Remaut, K. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.01.023 · Cited by 89
Tetrahedral framework nucleic acids prevent retina ischemia-reperfusion injury from oxidative stress via activating the Akt/Nrf2 pathway
Qin, X., Ni, L., Zhang, M., Lin, S., Zhu, J., Xiao, D., Cui, W., Zhang, T., Lin, Y., & Cai, X. (2019) · Nanoscale · doi:10.1039/c9nr07171g · Cited by 88
Leveraging Zebrafish to Study Retinal Degenerations
Angueyra, J. M., & Kindt, K. S. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00110 · Cited by 85
Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development
Wu, K. Y., Kulbay, M., Toameh, D., Xu, A. Q., Kalevar, A., & Tran, S. D. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020685 · Cited by 83
Review: The bile acids urso- and tauroursodeoxycholic acid as neuroprotective therapies in retinal disease.
Daruich, A., Picard, É., Boatright, J. H., & Béhar‐Cohen, F. (2019) · PubMed Central · Cited by 73
Autophagy and post-ischemic conditioning in retinal ischemia
Mathew, B., Chennakesavalu, M., Sharma, M., Torres, L. A., Stelman, C. R., Tran, S., Patel, R., Burg, N., Salkovski, M., Kadzielawa, K., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1767371 · Cited by 68
Non-viral delivery of chemically modified mRNA to the retina: Subretinal versus intravitreal administration
Devoldere, J., Peynshaert, K., Dewitte, H., Vanhove, C., Groef, L. D., Moons, L., Özcan, S. Y., Dalkara, D., Smedt, S. C. D., & Remaut, K. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.06.042 · Cited by 70
New nanoparticles for topical ocular delivery of erythropoietin
Silva, B., Marto, J. M., Bráz, B. S., Delgado, E., Almeida, A. J., & Gonçalves, L. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119020 · Cited by 66
Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic
Cordeiro, M. F., Hill, D., Patel, R. P., Corazza, P., Maddison, J., & Younis, S. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100976 · Cited by 67
Risk Factors for Retinal Ganglion Cell Distress in Glaucoma and Neuroprotective Potential Intervention
Vernazza, S., Oddone, F., Tirendi, S., & Bassi, A. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157994 · Cited by 68
Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress
Weh, E., Lutrzykowska, Z., Smith, A. J. H., Hager, H. M., Pawar, M. D., Wubben, T. J., & Besirli, C. G. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2638-2 · Cited by 60
Novel Detection and Restorative Levodopa Treatment for Preclinical Diabetic Retinopathy
Motz, C. T., Chesler, K. C., Allen, R. S., Bales, K. L., Mees, L. M., Feola, A., Maa, A. Y., Olson, D. E., Thulé, P. M., Iuvone, P. M., et al. (2020) · Diabetes · doi:10.2337/db19-0869 · Cited by 57
Self-citation
The Neuroprotective Effect of MicroRNA‐22‐3p Modified Tetrahedral Framework Nucleic Acids on Damaged Retinal Neurons Via TrkB/BDNF Signaling Pathway
Li, J., Xiao, L., Yan, N., Li, Y., Wang, Y., Qin, X., Zhao, D., Liu, M., Li, N., & Lin, Y. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202104141 · Cited by 57
Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness – a review
Sabel, B. A., Flammer, J., & Merabet, L. B. (2018) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-180880 · Cited by 58
Stargardt disease and progress in therapeutic strategies
Huang, D., Jeffery, R. C. H., Aung-Htut, M. T., McLenachan, S., Fletcher, S., Wilton, S. D., & Chen, F. K. (2021) · Ophthalmic Genetics · doi:10.1080/13816810.2021.1966053 · Cited by 57
Light-responsive polymeric nanoparticles for retinal drug delivery: design cues, challenges and future perspectives
Guidi, L., Cascone, M., & Rosellini, E. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26616 · Cited by 36
mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases
Wang, Y., Fung, N. S. K., Lam, W., & Lo, A. (2022) · Antioxidants · doi:10.3390/antiox11071304 · Cited by 52
Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina
Roche, S. L., Wyse‐Jackson, A. C., Ruiz‐Lopez, A. M., Byrne, A. M., & Cotter, T. G. (2017) · Scientific Reports · doi:10.1038/srep43067 · Cited by 46
Inherited Retinal Dystrophies: Role of Oxidative Stress and Inflammation in Their Physiopathology and Therapeutic Implications
Pinilla, I., Maneu, V., Campello, L., Fernández‐Sánchez, L., Martínez‐Gil, N., Kutsyr, O., Sánchez‐Sáez, X., Sánchez‐Castillo, C., Lax, P., & Cuenca, N. (2022) · Antioxidants · doi:10.3390/antiox11061086 · Cited by 44
Detection of Multi-Class Retinal Diseases Using Artificial Intelligence: An Expeditious Learning Using Deep CNN with Minimal Data
Karthikeyan, S., Sanjay Kumar, P., Madhusudan, R. J. M., Sundaramoorthy, S., & Namboori, P. K. K. (2019) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/1788 · Cited by 42
Gene Therapy for Inherited Retinal Diseases: From Laboratory Bench to Patient Bedside and Beyond
Brar, A. S., Parameswarappa, D. C., Takkar, B., Narayanan, R., Jalali, S., Mandal, S., Fujinami, K., & Padhy, S. K. (2023) · Ophthalmology and Therapy · doi:10.1007/s40123-023-00862-2 · Cited by 43
Combination therapy and co-delivery strategies to optimize treatment of posterior segment neurodegenerative diseases
Arranz-Romera, A., Esteban-Pérez, S., García-Herranz, D., Aragón-Navas, A., Bravo‐Osuna, I., & Herrero‐Vanrell, R. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.03.022 · Cited by 40
Recent Developments in Diabetic Retinal Neurodegeneration: A Literature Review
Pillar, S., Moisseiev, E., Sokolovska, J., & Grzybowski, A. E. (2020) · Journal of Diabetes Research · doi:10.1155/2020/5728674 · Cited by 42
Emerging Insights and Interventions for Diabetic Retinopathy
Honasoge, A., Nudleman, E., Smith, M. E., & Rajagopal, R. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1218-2 · Cited by 38
The Emerging Role of Topical Ocular Drugs to Target the Posterior Eye
Wang, L., Zhou, M., & Zhang, H. (2021) · Ophthalmology and Therapy · doi:10.1007/s40123-021-00365-y · Cited by 43
VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush
Takeuchi, H., Inagaki, S., Morozumi, W., Nakano, Y., Inoue, Y., Kuse, Y., Mizoguchi, T., Nakamura, S., Funato, M., Kaneko, H., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34585-3 · Cited by 37
Nerve Growth Factor-Based Therapy in Alzheimer’s Disease and Age-Related Macular Degeneration
Amadoro, G., Latina, V., Balzamino, B. O., Squitti, R., Varano, M., Calissano, P., & Micera, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.735928 · Cited by 44
Circular RNA-based therapy provides sustained and robust neuroprotection for retinal ganglion cells
Jiang, W., Xiao, D., Wu, C., Yang, J., Peng, X., Chen, L., Zhang, J., Zha, G.-F., Li, W., Ju, R., et al. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102258 · Cited by 41
Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies
Pavan, B., & Dalpiaz, A. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.06.009 · Cited by 32
Taurocholic acid inhibits features of age-related macular degeneration in vitro
Warden, C., Barnett, J. M., & Brantley, M. A. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.107974 · Cited by 31
KIT ligand protects against both light-induced and genetic photoreceptor degeneration
Li, H., Lian, L., Liu, B., Chen, Y., Yang, J., Jian, S., Zhou, J., Xu, Y., Ma, X., Qu, J., et al. (2020) · eLife · doi:10.7554/elife.51698 · Cited by 31
Neuroprotection in Glaucoma: Basic Aspects and Clinical Relevance
Kuo, C., & Liu, C. J.-L. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12111884 · Cited by 33
Inherited Eye Diseases with Retinal Manifestations through the Eyes of Homeobox Genes
Markitantova, Y. V., & Simirskii, V. N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051602 · Cited by 31
Pharmacological and Metabolic Significance of Bile Acids in Retinal Diseases
Win, A. S., Delgado, A. M., Jadeja, R. N., Martin, P. M., Bartoli, M., & Thounaojam, M. C. (2021) · Biomolecules · doi:10.3390/biom11020292 · Cited by 30
Inside out: Relations between the microbiome, nutrition, and eye health
Grant, M. B., Bernstein, P. S., Boesze‐Battaglia, K., Chew, E. Y., Curcio, C. A., Kenney, M. C., Klaver, C. C. W., Philp, N. J., Rowan, S., Sparrow, J. R., et al. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109216 · Cited by 32
CRISPR/Cas9—A Promising Therapeutic Tool to Cure Blindness: Current Scenario and Future Prospects
Ahmad, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911482 · Cited by 30
Disease mechanisms and neuroprotection by tauroursodeoxycholic acid in Rpgr knockout mice
Zhang, X., Shahani, U., Reilly, J., & Shu, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28519 · Cited by 29
Neuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models
Wu, J., zhang, D., Li, J., Li, J., Li, T., Wu, J., & Zhang, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05260-1 · Cited by 27
Coumestrol mitigates retinal cell inflammation, apoptosis, and oxidative stress in a rat model of diabetic retinopathy via activation of SIRT1
Xu, Y., Zhang, Y., Liang, H., & Liu, X. (2021) · Aging · doi:10.18632/aging.202467 · Cited by 27
The Next Generation of Molecular and Cellular Therapeutics for Inherited Retinal Disease
Velazquez, L. A. M., & Ballios, B. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111542 · Cited by 27
Implications of Neural Plasticity in Retinal Prosthesis
Caravaca-Rodriguez, D., Gaytan, S. P., Suaning, G. J., & Barriga‐Rivera, A. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.11.11 · Cited by 30
Neuroprotective Effect of Tauroursodeoxycholic Acid (TUDCA) on In Vitro and In Vivo Models of Retinal Disorders: A Systematic Review
Li, J., Huang, Z., Yu, J., Liang, L., Li, Y., Xu, K., Zhou, W., & Li, X. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230907152207 · Cited by 26
Aerobic exercise delays retinal ganglion cell death after optic nerve injury
He, Y., Wang, L., Zhang, T., Weng, S.-J., Lü, J., & Zhong, Y. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108240 · Cited by 26
Potential therapeutic strategies for photoreceptor degeneration: the path to restore vision
Karamali, F., Behtaj, S., Abraki, S. B., Hadady, H., Atefi, A., Savoj, S., Soroushzadeh, S., Najafian, S., Nasr‐Esfahani, M. H., & Klassen, H. J. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03738-4 · Cited by 27
Proteomic Study of Aqueous Humor and Its Application in the Treatment of Neovascular Glaucoma
Yu, M., Xie, F., Liu, X., Sun, H., Guo, Z., Liu, X., Li, W., Sun, W., Wang, Y., & He, C. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.587677 · Cited by 26
Protective effect of human umbilical cord mesenchymal stem cell-derived exosomes on rat retinal neurons in hyperglycemia through the brain-derived neurotrophic factor/TrkB pathway
Gao, X., Zhang, X., & Chen, S. (2021) · International Journal of Ophthalmology · doi:10.18240/ijo.2021.11.06 · Cited by 25
Acteoside protects retinal ganglion cells from experimental glaucoma by activating the PI3K/AKT signaling pathway via caveolin 1 upregulation
Xi, X., Chen, Q., Ma, J., Wang, X., Xia, Y., Wen, X., Cai, B., & Li, Y. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-136 · Cited by 24
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Bigini, F., Hyeon, L. S., Sun, Y. J., Sun, Y., & Mahajan, V. B. (2023) · Vision Research · doi:10.1016/j.visres.2023.108317 · Cited by 26
Subcutaneous delivery of tauroursodeoxycholic acid rescues the cone photoreceptors in degenerative retina: A promising therapeutic molecule for retinopathy
Tao, Y., Dong, X., Lu, X., Qu, Y., Wang, C., Peng, G.-H., & Zhang, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109021 · Cited by 25
Can Gene Therapy Transform the Treatment Landscape of Posterior Segment Eye Diseases? A Comprehensive Review of Recent Advancements
Chen, K.-S., Chan, H.-C., & Chan, C.-M. (2025) · Drugs · doi:10.1007/s40265-025-02237-2 · Cited by 22
CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10
Bucher, F., Aguilar, E., Marra, K. V., Rapp, J., Arnold, J., Diaz‐Aguilar, M. S., Lange, C., Agostini, H. T., Schlunck, G., Stahl, A., et al. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.10.20 · Cited by 22
Treatment with GDF15, a TGFβ superfamily protein, induces protective effect on retinal ganglion cells
Iwata, Y., Inagaki, S., Morozumi, W., Nakamura, S., Hara, H., & Shimazawa, M. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108338 · Cited by 22
Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres
Aragón-Navas, A., Rodrigo, M. J., García-Herranz, D., Martínez, T., Subías, M., Méndez-Martínez, S., Ruberte, J., Pampalona, J., Bravo‐Osuna, I., Garcia-Feijoo, J., et al. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2096712 · Cited by 22
Targeting molecular pathways for the treatment of inherited retinal degeneration
Kutluer, M., Huang, L., & Marigo, V. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.280303 · Cited by 21
Tauroursodeoxycholic Acid Protects Retinal and Visual Function in a Mouse Model of Type 1 Diabetes
Fu, J., Aung, M. H., Prunty, M. C., Hanif, A. M., Hutson, L. M., Boatright, J. H., & Pardue, M. T. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081154 · Cited by 22
Self-citation
Visual Dysfunction in Diabetes
Eggers, E. D. (2023) · Annual Review of Vision Science · doi:10.1146/annurev-vision-111022-123810 · Cited by 20
Hybrid Robot-Assisted Frameworks for Endomicroscopy Scanning in Retinal Surgeries
Li, Z., Shahbazi, M., Patel, N. A., O'Sullivan, E., Zhang, H., Vyas, K., Chalasani, P., Deguet, A., Gehlbach, P. L., Iordachita, I. I., et al. (2020) · IEEE Transactions on Medical Robotics and Bionics · doi:10.1109/tmrb.2020.2988312 · Cited by 20
Myosin 1f-mediated activation of microglia contributes to the photoreceptor degeneration in a mouse model of retinal detachment
Wang, Y., Zhao, X., Gao, M., Wan, X., Guo, Y., Qu, Y., Chen, Y., Li, T., Liu, H., Jiang, M., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03983-3 · Cited by 19
Current perspective on retinal remodeling: Implications for therapeutics
Pfeiffer, R. L., & Jones, B. W. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.1099348 · Cited by 19
Exploring Epigenetic Modifications as Potential Biomarkers and Therapeutic Targets in Glaucoma
Tonti, E., dell’Omo, R., Filippelli, M., Spadea, L., Salati, C., Gagliano, C., Musa, M., & Zeppieri, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052822 · Cited by 20
A sterilizable platform based on crosslinked xanthan gum for controlled-release of polymeric micelles: Ocular application for the delivery of neuroprotective compounds to the posterior eye segment
Signorini, S., Delledonne, A., Pescina, S., Bianchera, A., Sissa, C., Vivero-Lopez, M., Alvarez‐Lorenzo, C., Santi, P., Padula, C., & Nicoli, S. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124141 · Cited by 20
Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia–Reperfusion Injury by Activating Nrf2 Pathway
Sheng, L., Lu, B., Chen, H., Yun, D., Chen, C., Cai, W., Yang, Y., Tian, X., Huang, Z., Chi, W., et al. (2019) · Marine Drugs · doi:10.3390/md17050267 · Cited by 19
Functional Availability of ON-Bipolar Cells in the Degenerated Retina: Timing and Longevity of an Optogenetic Gene Therapy
Kralik, J., & Kleinlogel, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111515 · Cited by 18
Thioredoxin upregulation delays diabetes-induced photoreceptor cell degeneration via AMPK-mediated autophagy and exosome secretion
Ren, X. S., Lv, J., Wang, N., Liu, J., Gao, C., Wu, X., Yu, Y., Teng, Q., Dong, W., Kong, H., et al. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2022.109788 · Cited by 19
Immunology of Retinitis Pigmentosa and Gene Therapy–Associated UveitisPreprint
Yang, P. G., Mustafi, D., & Pepple, K. L. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041305 · Cited by 20
Potential in exosome-based targeted nano-drugs and delivery vehicles for posterior ocular disease treatment: from barriers to therapeutic application
Peng, X., Zhang, T., Liu, R., & Jin, X. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04798-w · Cited by 18
Noninvasive electrical stimulation as a neuroprotective strategy in retinal diseases: a systematic review of preclinical studies
Li, J., Zhou, W., Liang, L., Li, Y., Xu, K., Li, X., Huang, Z., & Yu, J. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04766-4 · Cited by 18
Müller Glial Cell–Dependent Regeneration of the Retina in Zebrafish and Mice
Jui, J., & Goldman, D. J. (2024) · Annual Review of Genetics · doi:10.1146/annurev-genet-111523-102000 · Cited by 19
Trans-ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration
Song, H., Bush, R. A., Zeng, Y., Qian, H., Wu, Z., & Sieving, P. A. (2019) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2018.12.006 · Cited by 17
Potential neuroprotective effect of stem cells from apical papilla derived extracellular vesicles enriched by lab-on-chip approach during retinal degeneration
Hadady, H., Karamali, F., Ejeian, F., Soroushzadeh, S., & Nasr‐Esfahani, M. H. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04375-2 · Cited by 17
Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
Gudapati, K., Singh, A., Clarkson-Townsend, D. A., Phillips, S. Q., Douglass, A., Feola, A., & Allen, R. S. (2020) · Journal of Visualized Experiments · doi:10.3791/61806 · Cited by 17
Self-citation
A Ketogenic & Low-Protein Diet Slows Retinal Degeneration in rd10 Mice
Ryals, R. C., Huang, S. J., Wafai, D., Bernert, C., Steele, W., Six, M., Bonthala, S., Titus, H. E., Yang, P. G., Gillingham, M. B., et al. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.11.18 · Cited by 16
Autophagy, lysosome dysfunction and mTOR inhibition in MNU-induced photoreceptor cell damage
Li, Y., Wang, C., Liu, Y., You, J., & Su, G. (2019) · Tissue and Cell · doi:10.1016/j.tice.2019.09.008 · Cited by 16
Advancing precision medicines for ocular disorders: Diagnostic genomics to tailored therapies
Panikker, P., Roy, S., Ghosh, A., Poornachandra, B., & Ghosh, A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.906482 · Cited by 17
Electrical, Electromagnetic, Ultrasound Wave Therapies, and Electronic Implants for Neuronal Rejuvenation, Neuroprotection, Axonal Regeneration, and IOP Reduction
Sharif, N. A. (2022) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2022.0046 · Cited by 18
Application of Programmable Tetrahedral Framework Nucleic Acid-Based Nanomaterials in Neurological Disorders: Progress and Prospects
Chen, X., Xie, Y., Liu, Z., & Lin, Y. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.782237 · Cited by 15
Aqueous Humor Biomarkers of Retinal Glial Cell Activation in Patients With or Without Age-Related Cataracts and With Different Stages of Diabetic Retinopathy
Zhao, M., Zhao, S., Tang, M. M., Sun, T., Zheng, Z. J., & Ma, M. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.3.8 · Cited by 15
The effect of taurine supplementation on delirium post liver transplantation: A randomized controlled trial
Mottaghi, S., Nikoupour, H., Firoozifar, M., Jalali, S. S., Jamshidzadeh, A., Vazin, A., & Shafiekhani, M. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.07.042 · Cited by 15
Gene Therapy for Inherited Retinal Disorders: Update on Clinical Trials
Michalakis, S., Gerhardt, M. J., Rudolph, G., Priglinger, S. G., & Priglinger, C. (2021) · Klinische Monatsblätter für Augenheilkunde · doi:10.1055/a-1384-0818 · Cited by 15
Mutation-independent therapies for retinal diseases: focus on gene-based approaches
Carrella, S., Indrieri, A., Franco, B., & Banfi, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.588234 · Cited by 14
Total cholesterol, high-density lipoprotein, and glucose (CHG) index and diabetic retinopathy in middle-aged and elderly Chinese adults with diabetes: a cross-sectional study
Cao, Y., He, Y., Zhu, J., & Han, Y. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1682279 · Cited by 14
Effects of Cord Blood Serum (CBS) on viability of retinal Müller glial cells under in vitro injury
Ciavarella, C., Buzzi, M., Bergantin, E., Marco, S. D., Giannaccare, G., Campos, E. C., Bisti, S., & Versura, P. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234145 · Cited by 14
Transcorneal Electrical Stimulation Dose-Dependently Slows the Visual Field Loss in Retinitis Pigmentosa
Stett, A., Schatz, A., Gekeler, F., & Franklin, J. G. (2023) · Translational Vision Science & Technology · doi:10.1167/tvst.12.2.29 · Cited by 14
Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and Degeneration
Weh, E., Goswami, M. T., Chaudhury, S., Fernando, R., Miller, N., Hager, H. M., Sheskey, S., Sharma, V., Wubben, T. J., & Besirli, C. G. (2023) · Cells · doi:10.3390/cells12162043 · Cited by 14
Hyperoside protects against oxidative stress-mediated photoreceptor degeneration: therapeutic potentials for photoreceptor degenerative diseases
Li, D., Xu, J., Chang, J., Wang, Y., Du, X., Wu, H., Cui, J., Wang, P., Zhang, T., & Chen, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04459-y · Cited by 14
Adult stem cells in the eye: Identification, characterisation, and therapeutic application in ocular regeneration – A review
Xiao, Y.-T., McGhee, C. N. J., & Zhang, J. (2024) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.14309 · Cited by 14

Authors: Pardue, M. T., & Allen, R. S.
Affiliations: Georgia Institute of Technology (US)
Atlanta VA Medical Center (US)
Corresponding author: Pardue, Machelle T.
ORCID: Pardue, Machelle T.
Allen, Rachael S.
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2018-07
Volume: 65
Pages: 50-76
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2018.02.002
PMC: PMC6081194
OpenAlex: W2793623156
Cited by: 237
References: 416
Citations by year: 2026: 21 · 2025: 24 · 2024: 30 · 2023: 31 · 2022: 37 · 2021: 37 · 2020: 32 · 2019: 19 · 2018: 5
FWCI: 2.28
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Progress in Retinal and Eye Research (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: IRB
National Institutes of Health (P30 EY006360)
Rehabilitation R&D Service of the Department of Veterans Affairs (I01RX000951)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Keywords: neuroprotection, retinal disease, photoreceptor degeneration, diabetic retinopathy, glaucoma, vision loss, bile acids, ursodeoxycholic acid, tauroursodeoxycholic acid, progesterone, retinal dopamine, neurotrophic factors, exercise therapy, electrical stimulation, retinal cell death, translational therapy
MeSH terms: Animals, Electric Stimulation Therapy, Exercise Therapy, Humans, Nerve Growth Factors, Neurons, Retina, Retinal Diseases, Taurochenodeoxycholic Acid, Ursodeoxycholic Acid, Vision Disorders, Cell Death, Neuroprotective Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroprotective strategies for retinal disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks