Cited by 237Retinal Development and DisordersRetinal Diseases and TreatmentsGlaucoma and retinal disorders

The DOI matches its Crossref record; 412 of the 416 references it cites were found in a registry or an index.

Neuroprotective strategies for retinal disease

Open access

Pardue, Machelle T., Allen, Rachael S.·2018·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2018.02.002PMC PMC6081194

Open this paper in CoChat — free account Open PDF

Abstract

Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of sight affects patient quality of life and puts an economic burden both on individuals and the greater healthcare system. Despite the urgent need for treatments, few effective options currently exist in the clinic. Here, we review research on promising neuroprotective strategies that promote neuronal survival with the potential to protect against vision loss and retinal cell death. Due to the large number of neuroprotective strategies, we restricted our review to approaches that we had direct experience with in the laboratory. We focus on drugs that target survival pathways, including bile acids like UDCA and TUDCA, steroid hormones like progesterone, therapies that target retinal dopamine, and neurotrophic factors. In addition, we review rehabilitative methods that increase endogenous repair mechanisms, including exercise and electrical stimulation therapies. For each approach, we provide background on the neuroprotective strategy, including history of use in other diseases; describe potential mechanisms of action; review the body of research performed in the retina thus far, both in animals and in humans; and discuss considerations when translating each treatment to the clinic and to the retina, including which therapies show the most promise for each retinal disease. Despite the high incidence of retinal diseases and the complexity of mechanisms involved, several promising neuroprotective treatments provide hope to prevent blindness. We discuss attractive candidates here with the goal of furthering retinal research in critical areas to rapidly translate neuroprotective strategies into the clinic.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.preteyeres.2018.02.002

Cites

412 of 412 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Optical Coherence Tomography
Huang, D., Swanson, E. A., Lin, C. P., Schuman, J. S., Stinson, W. G., Chang, W., Hee, M. R., Flotte, T., Gregory, K. W., Puliafito, C. A., et al. (1991) · Science · doi:10.1126/science.1957169 · Cited by 14,001
Diabetic Retinopathy
Lang, G. E., Vaiser, A., Snyder, W. B., & Lynn, J. R. (2007) · Developments in ophthalmology · doi:10.1159/isbn.978-3-318-01439-6 · Cited by 5,607
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855
The Pathophysiology and Treatment of Glaucoma: A Review
Weinreb, R. N., Aung, T., & Medeiros, F. A. (2014) · JAMA · doi:10.1001/jama.2014.3192 · Cited by 4,210
Reduction of Intraocular Pressure and Glaucoma Progression
Heijl, A. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.10.1268 · Cited by 3,407
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures
(1998) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(98)00223-2 · Cited by 1,596
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80900-9 · Cited by 1,534
Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein
Lotharius, J., & Brundin, P. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn983 · Cited by 1,319
Gene therapy restores vision in a canine model of childhood blindness
Acland, G. M., Aguirre, G. D., Ray, J., Zhang, Q., Aleman, T. S., Cideciyan, A. V., Pearce-Kelling, S. E., Anand, V., Zeng, Y., Maguire, A. M., et al. (2001) · Nature Genetics · doi:10.1038/ng0501-92 · Cited by 1,202 · cited 13×
“A leading theory is that increased IOP may alter the biomechanical aspects of the posterior globe, leading to increased pressure on the RGC axons as they exit the eye in the optic nerve that then leads to RGC apoptosis (Nguyen and Ethier, 2015).”
Influential
Inflammation in diabetic retinopathy
Tang, J. C. O., & Kern, T. S. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.05.002 · Cited by 1,127
Retinal ischemia: mechanisms of damage and potential therapeutic strategies
Osborne, N. N., Casson, R. J., Wood, J. P. M., Chidlow, G., Graham, M., & Melena, J. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2003.12.001 · Cited by 1,072
Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex
Bhutto, I. A., & Lutty, G. A. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.04.005 · Cited by 1,028
The molecular basis of retinal ganglion cell death in glaucoma
Almasieh, M., Wilson, A. M., Morquette, B., Vargas, J. L. C., & Polo, A. D. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.11.002 · Cited by 990
The arrangement of the three cone classes in the living human eye
Roorda, A., & Williams, D. R. (1999) · Nature · doi:10.1038/17383 · Cited by 986
Diabetic Retinopathy
Frank, R. N. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021678 · Cited by 906
Neural remodeling in retinal degeneration
Marc, R. E., Jones, B. W., Watt, C. B., & Strettoi, E. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(03)00039-9 · Cited by 891
Dopamine and retinal function
Witkovsky, P. (2004) · Documenta Ophthalmologica · doi:10.1023/b:doop.0000019487.88486.0a · Cited by 811
Diabetic Retinopathy
Antonetti, D. A., Barber, A. J., Bronson, S. K., Freeman, W. M., Gardner, T. W., Jefferson, L. S., KESTER, M. A., Kimball, S. R., Krady, J. K., LaNoue, K. F., et al. (2006) · Diabetes · doi:10.2337/db05-1635 · Cited by 758
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light.
LaVail, M. M., Unoki, K., Yasumura, D., Matthes, M. T., Yancopoulos, G. D., & Steinberg, R. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11249 · Cited by 722
Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor
Faktorovich, E. G., Steinberg, R. H., Yasumura, D., Matthes, M. T., & LaVail, M. M. (1990) · Nature · doi:10.1038/347083a0 · Cited by 710
A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children
Chaddock, L., Erickson, K. I., Prakash, R. S., Kim, J. S., Voss, M. W., VanPatter, M., Pontifex, M. B., Raine, L. B., Konkel, A., Hillman, C. H., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.049 · Cited by 687
Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration
Wenzel, A., Grimm, C., Samardzija, M., & Remé, C. E. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.08.002 · Cited by 655
Genes and mutations causing retinitis pigmentosa
Daiger, S. P., Sullivan, L. S., & Bowne, S. J. (2013) · Clinical Genetics · doi:10.1111/cge.12203 · Cited by 653
The effect of physical activity on cognitive function in patients with dementia: a meta-analysis of randomized control trials
Groot, C., Hooghiemstra, A. M., Raijmakers, P. G. H. M., van Berckel, B. N. M., Scheltens, P., Scherder, E. J. A., van der Flier, W. M., & Ossenkoppele, R. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.005 · Cited by 616
ProTECT: A Randomized Clinical Trial of Progesterone for Acute Traumatic Brain Injury
Wright, D. W., Kellermann, A. L., Hertzberg, V., Clark, P. L., Frankel, M., Goldstein, F. C., Salomone, J. P., Dent, L. L., Harris, O. A., Ander, D. S., et al. (2006) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2006.07.932 · Cited by 599
Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants
Sieving, P. A., Caruso, R. C., Tao, W., Coleman, H. R., Thompson, D. J. S., Fullmer, K. R., & Bush, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600236103 · Cited by 591
Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males
Griffin, É. W., Mullally, S. L., Foley, C., Warmington, S. A., O’Mara, S. M., & Kelly, A. M. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.06.005 · Cited by 581
Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease
Bernstein, P. S., Li, B., Vachali, P. P., Gorusupudi, A., Shyam, R., Henriksen, B. S., & Nolan, J. M. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.10.003 · Cited by 570
BDNF mediates adaptive brain and body responses to energetic challenges
Marosi, K., & Mattson, M. P. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.10.006 · Cited by 568
Very Early Administration of Progesterone for Acute Traumatic Brain Injury
Wright, D. W., Yeatts, S. D., Silbergleit, R., Palesch, Y. Y., Hertzberg, V. S., Frankel, M., Goldstein, F. C., Caveney, A. F., Howlett-Smith, H., Bengelink, E. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1404304 · Cited by 567
The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: Results of a one‐year exercise intervention
Voss, M. W., Heo, S., Prakash, R. S., Erickson, K. I., Alves, H., Chaddock, L., Szabo, A. N., Mailey, E. L., Wójcicki, T. R., White, S. M., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22119 · Cited by 553
The Artificial Silicon Retina Microchip for the Treatment of VisionLoss From Retinitis Pigmentosa
Chow, A. Y. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.460 · Cited by 512
A Clinical Trial of Progesterone for Severe Traumatic Brain Injury
Skolnick, B. E., Maas, A. I., Narayan, R. K., van der Hoop, R. G., MacAllister, T., Ward, J. D., Nelson, N. R., & Stocchetti, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1411090 · Cited by 505
Delivery of Neurotrophic Factors to the Central Nervous System: Pharmacokinetic Considerations
Thorne, R. G., & Frey, W. H. (2001) · Clinical Pharmacokinetics · doi:10.2165/00003088-200140120-00003 · Cited by 487
Retinal remodeling triggered by photoreceptor degenerations
Jones, B. W., Watt, C. B., Frederick, J. M., Baehr, W., Chen, C., Levine, E. M., Milam, A. H., Lavail, M. M., & Marc, R. E. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10703 · Cited by 476
Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial
Xiao, G., Wei, J., Yan, W., Wang, W., & Lu, Z. (2008) · Critical Care · doi:10.1186/cc6887 · Cited by 463
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
Monnet, F. P., Mahé, V, Robel, P., & Baulieu, E. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3774 · Cited by 429
Ursodeoxycholic acid ‘mechanisms of action and clinical use in hepatobiliary disorders’
Lazaridis, K. N., Gores, G. J., & Lindor, K. D. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00092-7 · Cited by 428
Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis
Aït-Ali, N., Fridlich, R., Millet-Puel, G., Clérin, E., Delalande, F., Jaillard, C., Blond, F., Perrocheau, L., Reichman, S., Byrne, L. C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.03.023 · Cited by 423
Neurobiological markers of exercise-related brain plasticity in older adults
Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Kim, J. S., Alves, H., Szabo, A., Phillips, S. M., Wójcicki, T. R., Mailey, E. L., et al. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.021 · Cited by 418
Regulation of hippocampal synaptic plasticity by BDNF
Leal, G., Afonso, P. M., Salazar, I. L., & Duarte, C. B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.019 · Cited by 410
Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases
Cuenca, N., Fernández-Sánchez, L., Campello, L., Maneu, V., De la Villa, P., Lax, P., & Pinilla, I. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.07.001 · Cited by 401
The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor
Basu, S., Nagy, J. A., Pal, S., Vasile, E., Eckelhoefer, I. A., Bliss, V. S., Manseau, E. J., Dasgupta, P., Dvorak, H. F., & Mukhopadhyay, D. (2001) · Nature Medicine · doi:10.1038/87895 · Cited by 396
Identification of androgen, estrogen and progesterone receptor mRNAs in the eye
Wickham, L. A., Gao, J., Toda, I., Rocha, E. M., Ono, M., & Sullivan, D. A. (2000) · Acta Ophthalmologica Scandinavica · doi:10.1034/j.1600-0420.2000.078002146.x · Cited by 393
Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice
Cazorla, M., Prémont, J., Mann, A., Girard, N., Kellendonk, C., & Rognan, D. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43992 · Cited by 392
The Neurosteroids Progesterone and Allopregnanolone Reduce Cell Death, Gliosis, and Functional Deficits after Traumatic Brain Injury in Rats
Djebaı̈li, M., Guo, Q., Pettus, E. H., Hoffman, S. W., & Stein, D. G. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.106 · Cited by 387
Exercise is brain food: The effects of physical activity on cognitive function
Ploughman, M. (2008) · Developmental Neurorehabilitation · doi:10.1080/17518420801997007 · Cited by 383
Promoting Neuroplasticity for Motor Rehabilitation After Stroke: Considering the Effects of Aerobic Exercise and Genetic Variation on Brain-Derived Neurotrophic Factor
Mang, C. S., Campbell, K. L., Ross, C. J., & Boyd, L. A. (2013) · Physical Therapy · doi:10.2522/ptj.20130053 · Cited by 378
Regular exercise improves cognitive function and decreases oxidative damage in rat brain
Radak, Z. O., Kaneko, T., Tahara, S., Nakamoto, H., Pucsok, J. M., Sasvári, M., Nyakas, C. J., & Goto, S. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00063-2 · Cited by 373
Incidence of Nonarteritic and Arteritic Anterior Ischemic Optic Neuropathy: Population-Based Study in the State of Missouri and Los Angeles County, California
Johnson, L. N., & Arnold, A. C. (1994) · Journal of Neuro-Ophthalmology · doi:10.1097/00041327-199403000-00011 · Cited by 359
Defining response to anti-VEGF therapies in neovascular AMD
Amoaku, W. M., Chakravarthy, U., Gale, R., Gavin, M., Ghanchi, F., Gibson, J., Harding, S., Johnston, R. L., Kelly, S., Lotery, A., et al. (2015) · Eye · doi:10.1038/eye.2015.48 · Cited by 355
Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat
Faktorovich, E. G., Steinberg, R. H., Yasumura, D., Matthes, M. T., & LaVail, M. M. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03554.1992 · Cited by 351
Prospective study of hallucinations and delusions in Parkinson's disease
Holroyd, S. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.6.734 · Cited by 346
Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy
Nickells, R. W., Howell, G. R., Soto, I., & John, S. W. M. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135728 · Cited by 344
Retinal remodeling in human retinitis pigmentosa
Jones, B. W., Pfeiffer, R. L., Ferrell, W. D., Watt, C. B., Marmor, M. F., & Marc, R. E. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.03.018 · Cited by 341
Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy
Kowluru, R. A., Kowluru, A., Mishra, M., & Kumar, B. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.05.001 · Cited by 339
Ursodeoxycholic Acid May Inhibit Deoxycholic Acid-Induced Apoptosis by Modulating Mitochondrial Transmembrane Potential and Reactive Oxygen Species Production
Rodrigues, C. M. P., Fan, G., Wong, P. Y., Kren, B. T., & Steer, C. J. (1998) · Molecular Medicine · doi:10.1007/bf03401914 · Cited by 335
Leber congenital amaurosis/early-onset severe retinal dystrophy: clinical features, molecular genetics and therapeutic interventions
Kumaran, N., Moore, A. T., Weleber, R. G., & Michaelides, M. (2017) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2016-309975 · Cited by 334
Impact of Progestins on Estrogen-Induced Neuroprotection: Synergy by Progesterone and 19-Norprogesterone and Antagonism by Medroxyprogesterone Acetate
Nilsen, J., & Brinton, R. D. (2002) · Endocrinology · doi:10.1210/endo.143.1.8582 · Cited by 331
Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa.
Tao, W., Wen, R., Goddard, M. B., Sherman, S., O'Rourke, P., Stabila, P. F., Bell, W. J., Dean, B. J., Kauper, K., Budz, V. A., et al. (2002) · PubMed · Cited by 325
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324
Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina
Wen, R., Song, Y., Cheng, T., Matthes, M. T., Yasumura, D., LaVail, M. M., & Steinberg, R. H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07377.1995 · Cited by 321
The primary vascular dysregulation syndrome: implications for eye diseases
Flammer, J., Konieczka, K., & Flammer, A. J. (2013) · The EPMA Journal · doi:10.1186/1878-5085-4-14 · Cited by 320
Steroid and G Protein Binding Characteristics of the Seatrout and Human Progestin Membrane Receptor α Subtypes and Their Evolutionary Origins
Thomas, P., Pang, Y., Dong, J., Groenen, P. M. A., Kelder, J., de Vlieg, J., Zhu, Y., & Tubbs, C. W. (2006) · Endocrinology · doi:10.1210/en.2006-0974 · Cited by 318
High-intensity compared to moderate-intensity training for exercise initiation, enjoyment, adherence, and intentions: an intervention study
Heinrich, K. M., Patel, P. M., O’Neal, J. L., & Heinrich, B. S. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-789 · Cited by 317
BDNF mediates improvements in executive function following a 1-year exercise intervention.
Leckie, R. L., Oberlin, L. E., Voss, M. W., Prakash, R. S., Szabo-Reed, A., Chaddock-Heyman, L., Phillips, S. M., Gothe, N. P., Mailey, E., Vieira-Potter, V. J., et al. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00985 · Cited by 307
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease
Keene, C. D., Rodrigues, C. M. P., Eich, T., Chhabra, M. S., Steer, C. J., & Low, W. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162362299 · Cited by 306
A community‐based exercise programme to improve functional ability in people with Alzheimer’s disease: a randomized controlled trial
Vreugdenhil, A., Cannell, J., Davies, A., & Razay, G. (2011) · Scandinavian Journal of Caring Sciences · doi:10.1111/j.1471-6712.2011.00895.x · Cited by 301
Dry Age-Related Macular Degeneration: Mechanisms, Therapeutic Targets, and Imaging
Rickman, C. B., Farsiu, S., Toth, C. A., & Klingeborn, M. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12757 · Cited by 293
Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum
Ghoumari, A. M., Ibanez, C., El‐Etr, M., Leclerc, P., Eychenne, B., O’Malley, B. W., Baulieu, E. E., & Schumacher, M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01881.x · Cited by 291
Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism
Maurice, T., Su, T., & Privat, A. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00405-3 · Cited by 291
How does age-related macular degeneration affect real-world visual ability and quality of life? A systematic review
Taylor, D. J., Hobby, A. E., Binns, A. M., & Crabb, D. P. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011504 · Cited by 289
Decreased dopamine in the retinas of patients with Parkinson's disease.
Harnois, C., & Paolo, T. D. (1990) · PubMed · Cited by 281
Dopaminergic neurons in the human retina
Frederick, J. M., Rayborn, M. E., Laties, A. M., Lam, D. M., & Hollyfield, J. G. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902100108 · Cited by 277
Progesterone modulates a neuronal nicotinic acetylcholine receptor.
Valera, S., Ballivet, M., & Bertrand, D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9949 · Cited by 277
Retinal stimulation strategies to restore vision: fundamentals and systems
Yue, L., Weiland, J. D., Roska, B., & Humayun, M. S. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.05.002 · Cited by 272
Long-Term Effects of Vitamins C and E, β-Carotene, and Zinc on Age-related Macular Degeneration
Chew, E. Y., Clemons, T. E., Agrón, E., Sperduto, R. D., SanGiovanni, J. P., Kurinij, N., & Davis, M. D. (2013) · Ophthalmology · doi:10.1016/j.ophtha.2013.01.021 · Cited by 270
Loss of melanin from human RPE with aging: possible role of melanin photooxidation
Sarna, T., Burke, J. M., Korytowski, W., Rôżanowska, M., Skumatz, C. M. B., Zaręba, A., & Zaręba, M. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(02)00247-6 · Cited by 263
Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications
Edelhauser, H. F., Rowe-Rendleman, C. L., Robinson, M. R., Dawson, D. G., Chader, G. J., Grossniklaus, H. E., Rittenhouse, K. D., WILSON, C. G., Weber, D. A., Kuppermann, B. D., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5392 · Cited by 262
Effects of apomorphine, a dopamine receptor agonist, on ocular refraction and axial elongation in a primate model of myopia.
Iuvone, P. M., Tigges, M., Stone, R. A., Lambert, S. R., & Laties, A. M. (1991) · PubMed · Cited by 256
Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy
Cideciyan, A. V. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.04.002 · Cited by 256
Embracing failure: What the Phase III progesterone studies can teach about TBI clinical trials
Stein, D. G. (2015) · Brain Injury · doi:10.3109/02699052.2015.1065344 · Cited by 249
Progesterone: Therapeutic opportunities for neuroprotection and myelin repair
Schumacher, M., Guennoun, R., Stein, D. G., & Nicola, A. F. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.001 · Cited by 247
Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease
Fisher, B. E., Li, Q., Nacca, A., Salem, G. J., Song, J., Yip, J., Hui, J. S., Jakowec, M. W., & Petzinger, G. M. (2013) · Neuroreport · doi:10.1097/wnr.0b013e328361dc13 · Cited by 247
Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye
Patel, S. R., Berezovsky, D. E., McCarey, B. E., Zarnitsyn, V. G., Edelhauser, H. F., & Prausnitz, M. R. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9872 · Cited by 246
Reduced response of retinal vessel diameters to flicker stimulation in patients with diabetes
Garhöfer, G. (2004) · British Journal of Ophthalmology · doi:10.1136/bjo.2003.033548 · Cited by 233
Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection.
Botla, R., Spivey, J. R., Aguilar, H. I., Bronk, S. F., & Gores, G. J. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24517-7 · Cited by 228
Adenovirus-Mediated Gene Transfer of Ciliary Neurotrophic Factor Can Prevent Photoreceptor Degeneration in the Retinal Degeneration ( rd ) Mouse
Cayouette, M., & Gravel, C. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.4-423 · Cited by 223
Loss of Cholinergic and Dopaminergic Amacrine Cells in Streptozotocin-Diabetic Rat and Ins2 Akita -Diabetic Mouse Retinas
Gastinger, M. J., Singh, R. S., & Barber, A. J. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1376 · Cited by 223
Long-Term Protection of Retinal Structure but Not Function Using RAAV.CNTF in Animal Models of Retinitis Pigmentosa
Liang, F.-Q., Alemán, T. S., Dejneka, N. S., Dudus, L., Fisher, K. J., Maguire, A. M., Jacobson, S. G., & Bennett, J. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0473 · Cited by 221
CNTF and retina
Wen, R., Tao, W., Li, Y., & Sieving, P. A. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.11.005 · Cited by 220
Neuroprotection, Growth Factors and BDNF-TrkB Signalling in Retinal Degeneration
Kimura, A. K., Namekata, K., Guo, X., Harada, C., & Harada, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091584 · Cited by 220
Neurotrophins and neurodegeneration
Dawbarn, D., & Allen, S. J. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.00487.x · Cited by 217
Exercise influences spatial learning in the radial arm maze
Anderson, B. J., Rapp, D. N., Baek, D. H., McCloskey, D. P., Coburn-Litvak, P. S., & Robinson, J. K. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00282-1 · Cited by 213
Female sex steroids: effects upon microglial cell activation
Drew, P. D., & Chavis, J. A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00386-6 · Cited by 209
Treatment of Parkinson's disease: levodopa as the first choice
Katzenschlager, R., & Lees, A. J. (2002) · Journal of Neurology · doi:10.1007/s00415-002-1204-4 · Cited by 209
Hybrid Dendrimer Hydrogel/PLGA Nanoparticle Platform Sustains Drug Delivery for One Week and Antiglaucoma Effects for Four Days Following One-Time Topical Administration
Yang, H., Tyagi, P., Kadam, R. S., Holden, C. A., & Kompella, U. B. (2012) · ACS Nano · doi:10.1021/nn301873v · Cited by 209
Neurostimulation Devices for the Treatment of Neurologic Disorders
Edwards, C. A., Kouzani, A. Z., Lee, K. H., & Ross, E. K. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.05.005 · Cited by 208
Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats
Guo, Q., Sayeed, I., Baronne, L. M., Hoffman, S. W., Guennoun, R., & Stein, D. G. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.12.013 · Cited by 207
The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases
Vang, S., Longley, K., Steer, C. J., & Low, W. C. (2014) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2014.017 · Cited by 202
Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior
Svensson, M., Lexell, J. E., & Deierborg, T. (2014) · Neurorehabilitation and neural repair · doi:10.1177/1545968314562108 · Cited by 202
L-DOPA Is an Endogenous Ligand for OA1
López‐Ozuna, V. M., Decatur, C. L., Stamer, W. D., Lynch, R. M., & McKay, B. S. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060236 · Cited by 202
Photoreceptors of mouse retinas possess D4 receptors coupled to adenylate cyclase.
Cohen, A. I., Todd, R. D., Harmon, S. K., & O’Malley, K. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12093 · Cited by 202
Progesterone as a neuroprotective factor in traumatic and ischemic brain injury
Sayeed, I., & Stein, D. G. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17515-5 · Cited by 201
Transcorneal Electrical Stimulation Rescues Axotomized Retinal Ganglion Cells by Activating Endogenous Retinal IGF-1 System
Morimoto, T., Miyoshi, T., Matsuda, S., Tano, Y., Fujikado, T., & Fukuda, Y. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1339 · Cited by 197
BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells
Maes, M. E., Schlamp, C. L., & Nickells, R. W. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.01.002 · Cited by 196
Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration
Byrne, L. C., Dalkara, D., Luna, G., Fisher, S. K., Clérin, E., Sahel, J., Léveillard, T., & Flannery, J. G. (2014) · Journal of Clinical Investigation · doi:10.1172/jci65654 · Cited by 195
Neuronal and Glial Cell Abnormality as Predictors of Progression of Diabetic Retinopathy
Fletcher, E. L., Phipps, J. A., Ward, M. M., Puthussery, T., & Wilkinson‐Berka, J. L. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207781662920 · Cited by 192
Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats
Speisman, R. B., Kumar, A., Rani, A., Foster, T. C., & Ormerod, B. K. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.013 · Cited by 187
Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Müller Cell–Derived Inflammatory Cytokine Production in Diabetes
Zhong, Y., Li, J., Chen, Y.-M., Wang, J., Ratan, R., & Zhang, S. X. (2012) · Diabetes · doi:10.2337/db11-0315 · Cited by 184
Sex steroids and 5-en-3β-hydroxysteroids in specific regions of the human brain and cranial nerves
Lanthier, A., & Patwardhan, V. V. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90259-1 · Cited by 182
Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation
Chan, J. R., Phillips, L. J., & Gläser, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10459 · Cited by 177
From oxygen to erythropoietin: Relevance of hypoxia for retinal development, health and disease
Caprara, C., & Grimm, C. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.11.003 · Cited by 176
Exercise intensity influences the temporal profile of growth factors involved in neuronal plasticity following focal ischemia.
Ploughman, M., Granter-Button, S., Chernenko, G., Attwood, Z., Tucker, B. A., Mearow, K. M., & Corbett, D. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.065 · Cited by 170
Pregnane X receptor (PXR) activation: A mechanism for neuroprotection in a mouse model of Niemann–Pick C disease
Langmade, S. J., Gale, S. E., Frolov, A., Mohri, I., Suzuki, K., Mellon, S. H., Walkley, S. U., Covey, D. F., Schaffer, J. E., & Ory, D. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606218103 · Cited by 168
Diagnosis and pathogenesis of glaucomatous optic neuropathy: morphological aspects1111Supported by Deutsche Forschungsgemeinschaft (SFB 539)
Jonas, J. B., & Budde, W. M. (2000) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(99)00002-6 · Cited by 167
Vision restoration after brain and retina damage: The “residual vision activation theory”
Sabel, B. A., Henrich‐Noack, P., Fedorov, A. B., & Gall, C. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53355-5.00013-0 · Cited by 166
Optical coherence tomography angiography: Technical principles and clinical applications in ophthalmology
Huang, D., Hagag, A. M., Gao, S., & Jia, Y. (2017) · Taiwan Journal of Ophthalmology · doi:10.4103/tjo.tjo_31_17 · Cited by 166
Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling
Sjøberg, K. A., Frøsig, C., Kjøbsted, R., Sylow, L., Kleinert, M., Betik, A. C., Shaw, C. S., Kiens, B., Wojtaszewski, J. F. P., Rattigan, S., et al. (2017) · Diabetes · doi:10.2337/db16-1327 · Cited by 164
Progesterone Improves Acute Recovery after Traumatic Brain Injury in the Aged Rat
Cutler, S. M., Cekic, M. M., Miller, D. M., Wali, B., VanLandingham, J. W., & Stein, D. G. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.0294 · Cited by 164
Visual Function, Social Position, and Health and Life Chances
Cumberland, P. M., & Rahi, J. S. (2016) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2016.1778 · Cited by 164
Complement factor H in AMD: Bridging genetic associations and pathobiology
Toomey, C. B., Johnson, L. V., & Rickman, C. B. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.09.001 · Cited by 162
Rodent Models for Glaucoma Retinopathy and Optic Neuropathy
Pang, I., & Clark, A. F. (2007) · Journal of Glaucoma · doi:10.1097/ijg.0b013e3181405d4f · Cited by 162
Electrical Stimulation as a Means for Improving Vision
Sehic, A., Guo, S., Cho, K., Corraya, R. M., Chen, D. F., & Utheim, T. P. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.07.017 · Cited by 162
Progesterone and allopregnanolone attenuate blood–brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases
Ishrat, T., Sayeed, I., Atif, F., Hua, F., & Stein, D. G. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.08.023 · Cited by 159
Forced treadmill exercise training exacerbates inflammation and causes mortality while voluntary wheel training is protective in a mouse model of colitis
Cook, M. D., Martin, S. A., Williams, C., Whitlock, K., Wallig, M. A., Pence, B. D., & Woods, J. A. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.05.005 · Cited by 153
Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2.
Lau, D., McGee, L. H., Zhou, S., Rendahl, K. G., Manning, W. C., Escobedo, J. A., & Flannery, J. G. (2000) · PubMed · Cited by 150
Anxiolytic activity of progesterone in progesterone receptor knockout mice
Reddy, D. S., O’Malley, B. W., & Rogawski, M. A. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.09.002 · Cited by 148
Progesterone treatment attenuates brain edema following contusion injury in male and female rats
Roof, R. L., Duvdevani, R., & Stein, D. G. (1992) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-1992-4608 · Cited by 147
Dopamine Deficiency Contributes to Early Visual Dysfunction in a Rodent Model of Type 1 Diabetes
Aung, M. H., Park, H. N., Han, M. K., Obertone, T. S., Abey, J., Aseem, F., Thulé, P. M., Iuvone, P. M., & Pardue, M. T. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3483-13.2014 · Cited by 144
Self-citation
Nonarteritic anterior ischemic optic neuropathy (NAION) and its experimental models
Bernstein, S. L., Johnson, M. A., & Miller, N. R. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.02.003 · Cited by 144
Retinopathy in Parkinson disease
Bodis-Wollner, I. G. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0292-z · Cited by 143
Effect of Transcorneal Electrical Stimulation in Patients with Nonarteritic Ischemic Optic Neuropathy or Traumatic Optic Neuropathy
Fujikado, T., Morimoto, T., Matsushita, K., Shimojo, H., Okawa, Y., & Tano, Y. (2006) · Japanese Journal of Ophthalmology · doi:10.1007/s10384-005-0304-y · Cited by 142
Light in retinitis pigmentosa
Kennan, A., Aherne, A., & Humphries, P. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.12.001 · Cited by 140
Immunohistochemical Localization of Dopamine D Receptors in Rat Retina
Veruki, M. L., & Wässle, H. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01192.x · Cited by 140
Hormonal state affects recovery from frontal cortex lesions in adult female rats
Attella, M. J., Nattinville, A., & Stein, D. G. (1987) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(87)90918-6 · Cited by 138
Regulation of TNF-alpha production in activated mouse macrophages by progesterone.
Miller, L., & Hunt, J. S. (1998) · PubMed · Cited by 136
Pregnancy-associated Retinal Diseases and Their Management
Errera, M., Kohly, R. P., & da Cruz, L. (2013) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2012.08.001 · Cited by 136
Electronic retinal implants and artificial vision: journey and present
Mills, J. O., Jalil, A., & Stanga, P. E. (2017) · Eye · doi:10.1038/eye.2017.65 · Cited by 133
A Bile Acid Protects against Motor and Cognitive Deficits and Reduces Striatal Degeneration in the 3-Nitropropionic Acid Model of Huntington's Disease
Keene, C. D., Rodrigues, C. M. P., Eich, T., Linehan-Stieers, C., Abt, A., Kren, B. T., Steer, C. J., & Low, W. C. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7755 · Cited by 132
Transcorneal Electrical Stimulation Promotes the Survival of Photoreceptors and Preserves Retinal Function in Royal College of Surgeons Rats
Morimoto, T., Fujikado, T., Choi, J., Kanda, H., Miyoshi, T., Fukuda, Y., & Tano, Y. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1404 · Cited by 132
Current management of glaucoma and the need for complete therapy.
McKinnon, S. J., Goldberg, L. D., Peeples, P., Walt, J. G., & Bramley, T. J. (2008) · PubMed · Cited by 129
Systemic progesterone administration results in a partial reversal of the age‐associated decline in CNS remyelination following toxin‐induced demyelination in male rats
Ibanez, C., Shields, S. A., El‐Etr, M., Baulieu, E. E., Schumacher, M., & Franklin, R. J. M. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2003.00515.x · Cited by 129
Progesterone up-regulates neuronal brain-derived neurotrophic factor expression in the injured spinal cord
González, S. L., Labombarda, F., Deniselle, M. C. G., Guennoun, R., Schumacher, M., & Nicola, A. F. D. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.02.024 · Cited by 128
Taurine: The comeback of a neutraceutical in the prevention of retinal degenerations
Froger, N., Moutsimilli, L., Cadetti, L., Jammoul, F., Wang, Q., Fan, Y., Gaucher, D., Rosolen, S. G., Neveux, N., Cynober, L., et al. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.03.001 · Cited by 127
Early Visual Deficits in Streptozotocin-Induced Diabetic Long Evans Rats
Aung, M. H., Kim, M., Olson, D. E., Thulé, P. M., & Pardue, M. T. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10927 · Cited by 126
Self-citation
The effect of Tai Chi exercise on gait initiation and gait performance in persons with Parkinson's disease
Amano, J., Nocera, J. R., Vallabhajosula, S., Juncos, J. L., Gregor, R. J., Waddell, D. E., Wolf, S. L., & Hass, C. J. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.06.007 · Cited by 125
Recent advances in treating Parkinson’s disease
Oertel, W. H. (2017) · F1000Research · doi:10.12688/f1000research.10100.1 · Cited by 125
Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein
Yoon, Y. M., Lee, J. H., Yun, S. P., Han, Y., Yun, C. W., Lee, H. J., Noh, H., Lee, S., Han, H. J., & Lee, S. H. (2016) · Scientific Reports · doi:10.1038/srep39838 · Cited by 124
Alternating Current Stimulation for Vision Restoration after Optic Nerve Damage: A Randomized Clinical Trial
Gall, C., Schmidt, S. H., Schittkowski, M., Antal, A., Ambrus, G. G., Paulus, W., Dannhauer, M., Michalik, R., Mante, A., Bola, M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156134 · Cited by 123
Non-invasive alternating current stimulation improves vision in optic neuropathy
Sabel, B. A., Fedorov, A. B., Naue, N., Borrmann, A., Herrmann, C. S., & Gall, C. (2011) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2011-0624 · Cited by 120
Neuroprotective Effect of Subretinal Implants in the RCS Rat
Pardue, M. T., Phillips, M. J., Yin, H., Sippy, B. D., Webb-Wood, S., Chow, A. Y., & Ball, S. L. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0515 · Cited by 119
Self-citation
Trophic factors in the pathogenesis and therapy for retinal degenerative diseases
Kolomeyer, A. M., & Zarbin, M. A. (2014) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2013.09.004 · Cited by 119
Brain functional connectivity network breakdown and restoration in blindness
Bola, M., Gall, C., Moewes, C., Fedorov, A. B., Hinrichs, H., & Sabel, B. A. (2014) · Neurology · doi:10.1212/wnl.0000000000000672 · Cited by 116
Physical activity and the 15-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye study
Knudtson, M. D., Klein, R., & Klein, B. E. K. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2006.103796 · Cited by 115
Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway
Ishrat, T., Sayeed, I., Atif, F., Hua, F., & Stein, D. G. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.008 · Cited by 115
Neuroprotective effect of transcorneal electrical stimulation on light-induced photoreceptor degeneration
Ni, Y., Gan, D., Xu, H., Xu, G., & Da, C. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.06.016 · Cited by 115
Diagnostic Sensitivity and Specificity of Dark Adaptometry for Detection of Age-Related Macular Degeneration
Jackson, G. R., Scott, I. U., Kim, I. K., Quillen, D. A., Iannaccone, A., & Edwards, J. G. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13745 · Cited by 113
Long-term follow-up of patients with retinitis pigmentosa receiving intraocular ciliary neurotrophic factor implants
Birch, D. G., Bennett, L. D., Duncan, J. L., Weleber, R. G., & Pennesi, M. E. (2016) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2016.07.013 · Cited by 112
Progesterone Differentially Regulates Pro- and Anti-Apoptotic Gene Expression in Cerebral Cortex Following Traumatic Brain Injury in Rats
Yao, X.-L., Liu, J., Lee, E., Ling, G. S. F., & McCabe, J. T. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.656 · Cited by 112
Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration
Oveson, B. C., Iwase, T., Hackett, S. F., Lee, S. Y., Usui, S., Sedlak, T. W., Snyder, S. H., Campochiaro, P. A., & Sung, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07092.x · Cited by 111
Relationship Between Foveal Cone Structure and Clinical Measures of Visual Function in Patients With Inherited Retinal Degenerations
Ratnam, K., Carroll, J., Porco, T. C., Duncan, J. L., & Roorda, A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12557 · Cited by 111
Regulation of TNF-α Production in Activated Mouse Macrophages by Progesterone
Miller, L. D., & Hunt, J. S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.5098 · Cited by 111
Tauroursodeoxycholic Acid Prevents Retinal Degeneration in Transgenic P23H Rats
Fernández‐Sánchez, L., Lax, P., Pinilla, I., Martín‐Nieto, J., & Cuenca, N. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7496 · Cited by 110
Neurosteroidogenesis in Rat Retinas
Guarneri, P., Guarneri, R., Cascio, C., Pavasant, P., Piccoli, F., & Papadopoulos, V. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63010086.x · Cited by 110
Assessing Photoreceptor Structure in Retinitis Pigmentosa and Usher Syndrome
Sun, L. W., Johnson, R. D., Langlo, C. S., Cooper, R. F., Razeen, M. M., Russillo, M. C., Dubra, A., Connor, T. B., Han, D. P., Pennesi, M. E., et al. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18246 · Cited by 110
BDNF is Upregulated by Postnatal Development and Visual Experience: Quantitative and Immunohistochemical Analyses of BDNF in the Rat Retina
Seki, M., Nawa, H., Fukuchi, T., Abe, H., & Takei, N. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1089 · Cited by 109
BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson s disease
Real, C. C., Ferreira, A. F. B., Chaves-Kirsten, G. P., Torrão, A. S., Pires, R. S., & Britto, L. R. G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.060 · Cited by 109
Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma‐related mental health
Zhu, M., Lai, J. S. M., Choy, B. N. K., Shum, J. W. H., Lo, A., Ng, A. L. K., Chan, J. C. H., & So, K. (2018) · Acta Ophthalmologica · doi:10.1111/aos.13661 · Cited by 109
Tauroursodeoxycholic Acid Improves the Survival and Function of Nigral Transplants in a Rat Model of Parkinson's Disease
Duan, W., Rodrigures, C. M. P., Zhao, L., Steer, C. J., & Low, W. C. (2002) · Cell Transplantation · doi:10.3727/096020198389960 · Cited by 108
Progesterone in the clinical treatment of acute traumatic brain injury
Stein, D. G., & Wright, D. W. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.489549 · Cited by 108
Visual evoked potentials in parkinsonism and dopamine blockade reveal a stimulus-dependent dopamine function in humans.
ONOFRJ, M. C., Ghilardi, M. F., Basciani, M., & Gambi, D. (1986) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.49.10.1150 · Cited by 108
Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain
Cooper, M. A., Kluding, P. M., & Wright, D. E. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00372 · Cited by 105
Electrophysiological signs of retinal dopamine deficiency in recently diagnosed Parkinson's disease and a follow up study
Ikeda, H., Head, G. M., & Ellis, C. J. (1994) · Vision Research · doi:10.1016/0042-6989(94)90248-8 · Cited by 105
Tauroursodeoxycholic Acid (TUDCA) Protects Photoreceptors from Cell Death after Experimental Retinal Detachment
Mantopoulos, D., Murakami, Y., Comander, J., Thanos, A., Roh, M., Miller, J. W., & Vavvas, D. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024245 · Cited by 103
Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration
Brilliant, M. H., Vaziri, K., Connor, T. B., Schwartz, S. G., Carroll, J. J., McCarty, C. A., Schrodi, S. J., Hebbring, S. J., Kishor, K. S., Flynn, H. W., et al. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.10.015 · Cited by 102
Progesterone Exacerbates Striatal Stroke Injury in Progesterone-Deficient Female Animals
Murphy, S. J., Traystman, R. J., & Hurn, P. D. (2000) · Stroke · doi:10.1161/01.str.31.5.1173 · Cited by 102
TUDCA Slows Retinal Degeneration in Two Different Mouse Models of Retinitis Pigmentosa and Prevents Obesity in Bardet-Biedl Syndrome Type 1 Mice
Drack, A. V., Dumitrescu, A. V., Bhattarai, S., Gratie, D., Stone, E. M., Mullins, R. F., & Sheffield, V. C. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8544 · Cited by 101
Noninvasive transorbital alternating current stimulation improves subjective visual functioning and vision-related quality of life in optic neuropathy
Gall, C., Sgorzaly, S., Schmidt, S. H., Brandt, S. A., Fedorov, A. B., & Sabel, B. A. (2011) · Brain stimulation · doi:10.1016/j.brs.2011.07.003 · Cited by 101
Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects
Noailles, A., Fernández‐Sánchez, L., Lax, P., & Cuenca, N. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0186-3 · Cited by 100
Electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo
Morimoto, T., Miyoshi, T., Fujikado, T., Tano, Y., & Fukuda, Y. (2002) · Neuroreport · doi:10.1097/00001756-200202110-00011 · Cited by 99
Progesterone Attenuates Hemorrhagic Transformation after Delayed tPA Treatment in an Experimental Model of Stroke in Rats: Involvement of the VEGF–MMP Pathway
Won, S., Lee, J. H., Wali, B., Stein, D. G., & Sayeed, I. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.163 · Cited by 99
Neuroprotective Effect of Transcorneal Electrical Stimulation on the Acute Phase of Optic Nerve Injury
Miyake, K.-I., Yoshida, M., Inoue, Y., & Hata, Y. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1329 · Cited by 99
Transcorneal Electrical Stimulation for Patients With Retinitis Pigmentosa: A Prospective, Randomized, Sham-Controlled Follow-up Study Over 1 Year
Schatz, A., Pach, J., Gosheva, M., Naycheva, L., Willmann, G., Wilhelm, B., Peters, T. M., Bartz‐Schmidt, K. U., Zrenner, E., Messias, A. M. V., et al. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19906 · Cited by 99
Activity and localization of 3β‐hydroxysteroid dehydrogenase/ Δ5‐Δ4‐isomerase in the zebrafish central nervous system
Sakamoto, H., Ukena, K., & Tsutsui, K. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1351 · Cited by 94
Electrical stimulation of visual cortex: relevance for the development of visual cortical prosthetics
Bosking, W. H., Beauchamp, M. S., & Yoshor, D. (2017) · Annual Review of Vision Science · doi:10.1146/annurev-vision-111815-114525 · Cited by 93 · cited 1×
“For vision, two types of neurostimulation are being used: prosthetics to activate visual circuits by stimulating retinal neurons directly or by stimulating the visual cortex, thereby restoring visual function (Bosking et al., 2017; Cheng et al., 2017), and low level electrical stimulation M.”
Vascular pathogenesis of normal-tension glaucoma: a possible pathogenetic factor, other than intraocular pressure, of glaucomatous optic neuropathy
Yamamoto, T., & Kitazawa, Y. (1998) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(97)00009-8 · Cited by 92
Tauroursodeoxycholic Acid Preservation of Photoreceptor Structure and Function in the rd10 Mouse through Postnatal Day 30
Phillips, M. J., Walker, T. A., Choi, H., Faulkner, A. E., Kim, M., Sidney, S. S., Boyd, A. P., Nickerson, J. M., Boatright, J. H., & Pardue, M. T. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1012 · Cited by 92
Self-citation
Editorial [Hot Topic: Clinics, Epidemiology and Genetics of Retinitis Pigmentosa (Guest Editor: Francesco Parmeggiani)]
Parmeggiani, F. (2011) · Current Genomics · doi:10.2174/138920211795860080 · Cited by 91
β-Human Chorionic Gonadotropin, Progesterone, and Aqueous Dynamics During Pregnancy
Ziai, N. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090180099043 · Cited by 91
Impaired Visual Acuity as a Risk Factor for Visual Hallucinations in Parkinson’s Disease
Matsui, H., Udaka, F., Tamura, A., Oda, M., Kubori, T., Nishinaka, K., & Kameyama, M. (2006) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988705284739 · Cited by 91
Transcorneal electrical stimulation of retina to treat longstanding retinal artery occlusion
Inomata, K., Shinoda, K., Ohde, H., Tsunoda, K., Hanazono, G., Kimura, I., Yuzawa, M., Tsubota, K., & Miyake, Y. (2007) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-007-0610-9 · Cited by 90
Regulation of Rod Phototransduction Machinery by Ciliary Neurotrophic Factor
Wen, R., Song, Y., Kjellström, S., Tanikawa, A., Liu, Y., Li, Y., Zhao, L., Bush, R. A., Laties, A. M., & Sieving, P. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4021-06.2006 · Cited by 89
Exercise reverses age‐related vulnerability of the retina to injury by preventing complement‐mediated synapse elimination via a BDNF ‐dependent pathway
Chrysostomou, V., Galić, S., van Wijngaarden, P., Trounce, I. A., Steinberg, G. R., & Crowston, J. G. (2016) · Aging Cell · doi:10.1111/acel.12512 · Cited by 89
Tool from ancient pharmacopoeia prevents vision loss.
Boatright, J. H., Moring, A. G., McElroy, C., Phillips, M. J., Do, V. T., Chang, B., Hawes, N. L., Boyd, A. P., Sidney, S. S., Stewart, R. E., et al. (2006) · PubMed · Cited by 88
Self-citation
Progesterone Increases Circulating Endothelial Progenitor Cells and Induces Neural Regeneration after Traumatic Brain Injury in Aged Rats
Li, Z., Wang, B., Kan, Z., Zhang, B., Yang, Z. R., Chen, J., Wang, D., Wei, H., Zhang, J.-N., & Jiang, R. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1807 · Cited by 88
Cone Structure Imaged With Adaptive Optics Scanning Laser Ophthalmoscopy in Eyes With Nonneovascular Age-Related Macular Degeneration
Zayit‐Soudry, S., Duncan, J. L., Syed, R., Menghini, M., & Roorda, A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12433 · Cited by 87
Restoration of vision after optic nerve lesions with noninvasive transorbital alternating current stimulation: a clinical observational study
Fedorov, A. B., Jobke, S., Берснев, В. П., Chibisova, A. N., Chibisova, Y., Gall, C., & Sabel, B. A. (2011) · Brain stimulation · doi:10.1016/j.brs.2011.07.007 · Cited by 86

Research works printed but not linked: 2

Cidian, 2004, vol. 2
Obal, 1950, Klinische Monatsblatter fur Augenheilkunde und fur augenarztliche Fortbildung, Klin. Monbl. Augenheilkd Augenarztl Fortbild, 117, 201

Sorted by citations

Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives
Han, H., Li, S., Xu, M., Zhong, Y., Fan, W., Xu, J., Zhou, T., Ji, J., Ye, J., & Yao, K. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114770 · Cited by 341
Lipid nanoparticles for delivery of messenger RNA to the back of the eye
Patel, S., Ryals, R. C., Weller, K. K., Pennesi, M. E., & Sahay, G. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.015 · Cited by 260
Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities
Schneider, N., Sundaresan, Y., Gopalakrishnan, P., Beryozkin, A., Hanany, M., Levanon, E. Y., Banin, E., Ben‐Aroya, S., & Sharon, D. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101029 · Cited by 231
Immune responses to injury and their links to eye disease
Stepp, M. A., & Menko, A. S. (2021) · Translational research · doi:10.1016/j.trsl.2021.05.005 · Cited by 204
Treatments for dry age-related macular degeneration: therapeutic avenues, clinical trials and future directions
de Guimarães, T. A. C., Varela, M. D., Georgiou, M., & Michaelides, M. (2021) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2020-318452 · Cited by 197

See all 237

Authors: Pardue, M. T., & Allen, R. S.
Affiliations: Georgia Institute of Technology (US)
Atlanta VA Medical Center (US)
Corresponding author: Pardue, Machelle T.
ORCID: Pardue, Machelle T.
Allen, Rachael S.
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2018-07
Volume: 65
Pages: 50-76
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2018.02.002
PMC: PMC6081194
OpenAlex: W2793623156
Cited by: 237
References: 416
Citations by year: 2026: 21 · 2025: 24 · 2024: 30 · 2023: 31 · 2022: 37 · 2021: 37 · 2020: 32 · 2019: 19 · 2018: 5
FWCI: 2.28
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Progress in Retinal and Eye Research (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: IRB
National Institutes of Health (P30 EY006360)
Rehabilitation R&D Service of the Department of Veterans Affairs (I01RX000951)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Keywords: neuroprotection, retinal disease, photoreceptor degeneration, diabetic retinopathy, glaucoma, vision loss, bile acids, ursodeoxycholic acid, tauroursodeoxycholic acid, progesterone, retinal dopamine, neurotrophic factors, exercise therapy, electrical stimulation, retinal cell death, translational therapy
MeSH terms: Animals, Electric Stimulation Therapy, Exercise Therapy, Humans, Nerve Growth Factors, Neurons, Retina, Retinal Diseases, Taurochenodeoxycholic Acid, Ursodeoxycholic Acid, Vision Disorders, Cell Death, Neuroprotective Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroprotective strategies for retinal disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks