The DOI matches its Crossref record; 268 of the 270 references it cites were found in a registry or an index.
Innate immune response in retinal homeostasis and inflammatory disorders
Abstract
Innate immune cells such as neutrophils, monocyte-macrophages and microglial cells are pivotal for the health and disease of the retina. For the maintenance of retinal homeostasis, these cells and immunosuppressive molecules in the eye actively regulate the induction and the expression of inflammation in order to prevent excessive activation and subsequent tissue damage. In the disease context, these regulatory mechanisms are modulated genetically and/or by environmental stimuli such as damage-associated molecular patterns (DAMPs), and a chronic innate immune response regulates or contributes to the formation of diverse retinal disorders such as uveitis, retinitis pigmentosa, retinal vascular diseases and retinal fibrosis. Here we summarize the recent knowledge regarding the innate immune response in both ocular immune regulation and inflammatory retinal diseases, and we describe the potential of the innate immune response as a biomarker and therapeutic target.
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“During stronger challenges, disruption of the immune privilege may occur.Recruitment and activation of circulating or resident immune cells in the retina, potentially including T cells, usually result in a full-fledged immune response and inflammation, causing permanent tissue damage [30,31].”
From Risk mitigation of immunogenicity: a key to personalized retinal gene therapy (2021) · cites this paper as [30]
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Metadata
- Authors
- Murakami, Y., Ishikawa, K., Nakao, S., & Sonoda, K.-H.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Sonoda, Koh-Hei
- Venue
- Progress in Retinal and Eye Research
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 74
- Pages
- 100778
- ISSN
- 1350-9462 (ISSN-L)
- OpenAlex
- W2972023044
- Cited by
- 125
- References
- 270
- Citations by year
- 2026: 12 · 2025: 29 · 2024: 28 · 2023: 14 · 2022: 16 · 2021: 16 · 2020: 10
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Retinal and Eye Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (16H06268, 17H05101, 17K11456, 18H02956, 19K09952)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- innate immunity, retinal homeostasis, retinal inflammation, microglia, monocytes/macrophages, neutrophils, damage-associated molecular patterns, uveitis, retinitis pigmentosa, retinal vascular disease, retinal fibrosis, biomarkers, therapeutic target
- MeSH terms
- Animals, Homeostasis, Humans, Immunity, Innate, Retina, Retinal Diseases
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