Cited by 125Ocular Diseases and Behçet’s SyndromeRetinal Diseases and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Innate immune response in retinal homeostasis and inflammatory disorders

Murakami, Yusuke, Ishikawa, Keijiro, Nakao, Shintaro, Sonoda, Koh-Hei·2020·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2019.100778

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Abstract

Innate immune cells such as neutrophils, monocyte-macrophages and microglial cells are pivotal for the health and disease of the retina. For the maintenance of retinal homeostasis, these cells and immunosuppressive molecules in the eye actively regulate the induction and the expression of inflammation in order to prevent excessive activation and subsequent tissue damage. In the disease context, these regulatory mechanisms are modulated genetically and/or by environmental stimuli such as damage-associated molecular patterns (DAMPs), and a chronic innate immune response regulates or contributes to the formation of diverse retinal disorders such as uveitis, retinitis pigmentosa, retinal vascular diseases and retinal fibrosis. Here we summarize the recent knowledge regarding the innate immune response in both ocular immune regulation and inflammatory retinal diseases, and we describe the potential of the innate immune response as a biomarker and therapeutic target.

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Authors: Murakami, Y., Ishikawa, K., Nakao, S., & Sonoda, K.-H.
Affiliations: Kyushu University (JP)
Corresponding author: Sonoda, Koh-Hei
ORCID: Murakami, Yusuke
Ishikawa, Keijiro
Nakao, Shintaro
Sonoda, Koh-Hei
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2020-01
Volume: 74
Pages: 100778
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2019.100778
OpenAlex: W2972023044
Cited by: 125
References: 270
Citations by year: 2026: 12 · 2025: 29 · 2024: 28 · 2023: 14 · 2022: 16 · 2021: 16 · 2020: 10
FWCI: 1.94
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Progress in Retinal and Eye Research (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology (16H06268, 17H05101, 17K11456, 18H02956, 19K09952)
Topics: Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: innate immunity, retinal homeostasis, retinal inflammation, microglia, monocytes/macrophages, neutrophils, damage-associated molecular patterns, uveitis, retinitis pigmentosa, retinal vascular disease, retinal fibrosis, biomarkers, therapeutic target
MeSH terms: Animals, Homeostasis, Humans, Immunity, Innate, Retina, Retinal Diseases

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Innate immune response in retinal homeostasis and inflammatory disorders

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