Optimization of medium composition for the production of clavulanic acid by Streptomyces clavuligerus
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The choice of soybean flour or soy protein isolate in fermentation media affects clavulanic acid production by S. clavuligerus.
“The choice of soybean flour or soy protein isolate in fermentation media affects the production of clavulanic acid by S. clavuligerus (Gouveia et al., 1999; Wang et al., 2005; Ortiz et al., 2007).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Wang et al., 2005
Wang et al. (2005) suggested optimal concentrations of soy meal powder (38.102 g/L), FeSO4.7H2O (0.395 g/L), and ornithine (1.177 g/L) for clavulanic acid production.
“By combining factional factorial design and response surface methodology, the study suggested optimal concentration of three of the most important components identified via factional factorial design—soy meal powder (38.102 g/L), FeSO4.7H2O (0.395 g/L), and ornithine (1.177 g/L).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Wang et al. (2005)
Wang et al. (2005) proposed using statistical methods to optimize the fermentation media for clavulanic acid production by S. clavuligerus.
“For instance, Wang et al. (2005) proposed using statistical methods to optimize the fermentation media for clavulanic acid production by S. clavuligerus.”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Wang et al. (2005)
Cites
Naturally-occurring beta-lactamase inhibitors with antibacterial activity
BROWN, A. G., BUTTERWORTH, D., COLE, M., HANSCOMB, G., HOOD, J. D., READING, C., & ROLINSON, G. N. (1976) · The Journal of Antibiotics · doi:10.7164/antibiotics.29.668 · Cited by 399 · see citing works
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Bioprocess optimization using design-of-experiments methodology
Mandenius, C., & Brundin, A. (2008) · Biotechnology Progress · doi:10.1002/btpr.67 · Cited by 422 · see citing works
Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
“The choice of soybean flour or soy protein isolate in fermentation media affects the production of clavulanic acid by S. clavuligerus (Gouveia et al., 1999; Wang et al., 2005; Ortiz et al., 2007).”
BackgroundMethod
- Authors
- Wang, Y.-H., Yang, B., Ren, J., Dong, M.-L., Liang, D., & Xu, A.-L.
- Affiliations
- South China University of Technology (CN)
- Sun Yat-sen University (CN)
- Venue
- Process Biochemistry
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 40
- Issue
- 3-4
- Pages
- 1161-1166
- ISSN
- 0032-9592 (ISSN-L)
- 1359-5113
- OpenAlex
- W2003516788
- Cited by
- 45
- References
- 1
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Process Biochemistry (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- clavulanic acid, Streptomyces clavuligerus, fermentation medium optimization, iron sulfate, ornithine, culture medium composition, antibiotic production
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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