Assessment of the Biocompatibility of the PLLA-PLCL Scaffold Obtained by Electrospinning
Open accessAbstract
Electrospun membranes of poly (L-Lactide) / poly (L-lactide-co-caprolactone) blend were produced and evaluated by physical and mechanical tests to use as a scaffold for cell growth. The membranes were seeded with endothelial cells (HUVEC) and after culturing time it was visualized by confocal laser scanning microscopy and scanning electron microscopy. The results indicate that the process parameters were capable of producing PLLA-PLCL membranes presenting fibers with diameters in the nanometer range. The scaffolds supported cell attachment and growth, indicating the feasibility of producing scaffolds by electrospinning technique, which could be used in tissue engineering applications.
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Compared with other biomaterials, PLCL exhibits core advantages including excellent biocompatibility and flexible tunability of degradation rate and mechanical properties, enabling adaptability to diverse tissue engineering scenarios.
“Compared with other biomaterials, PLCL exhibits core advantages including excellent biocompatibility and flexible tunability of degradation rate and mechanical properties, thereby enabling adaptability to diverse tissue engineering scenarios [66, 67].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [67]
The Proliferation Assay section (page unavailable) reports that a PLLA–PLCL blend scaffold supported cell attachment, adhesion and proliferation. The Mechanical Properties section (page unavailable) says scaffold strength depends on fiber composition, but the paper does not establish tunable degradation rates or comparative advantages over other biomaterials, nor does it demonstrate suitability across diverse tissue-engineering scenarios. (LLM, conf=0.86)
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- Authors
- Oyama, H. T. T., Cortella, L. R. X., Rosa, I. N. S., Filho, L. E. R., Hui, W. S., Cestari, I. N., & Cestari, I. A.
- Affiliations
- Instituto do Coração - HCFMUSP (BR)
- Universidade de São Paulo (BR)
- Corresponding author
- Oyama, Helena T.T.
- Venue
- Procedia Engineering
- Publisher
- Elsevier BV
- Published
- 2015
- Volume
- 110
- Pages
- 135-142
- ISSN
- 1877-7058 (ISSN-L)
- OpenAlex
- W1026993528
- Cited by
- 9
- References
- 22
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2015: 1
- FWCI
- 6.08
- Type
- conference paper
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Procedia Engineering (publishedVersion, cc-by-nc-nd)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (12/50283-6)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- biocompatibility, electrospinning, poly(L-lactic acid), poly(L-lactide-co-ε-caprolactone), scaffolds, endothelial cells, human umbilical vein endothelial cells, cell attachment, nanofibers, tissue engineering
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