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Reduced cerebral glucose metabolism in patients at risk for Alzheimer's disease
Abstract
While significantly reduced glucose metabolism in fronto-temporo-parietal and cingulate cortices has been demonstrated in Alzheimer's disease (AD) compared with controls, cerebral glucose metabolism in patients with mild cognitive impairment who subsequently develop AD is less well-defined. In the present study we measured cerebral glucose metabolism by positron emission tomography (PET) with (18)F-2-fluoro-2-deoxy-D-glucose in 14 patients with aging-associated cognitive decline (AACD), 44 patients with AD, and 14 healthy control subjects at baseline. The AACD patients were clinically followed up, and conversion to AD was determined. Compared with controls, AACD patients had significantly reduced glucose metabolism in the right precuneus, posterior cingulate, right angular gyrus, and bilateral middle temporal cortices, while the respective deficits were more pronounced in AD patients and also involved the frontal cortices. AACD patients who subsequently converted to AD (AACD-converters) showed more extended metabolic changes which also involved the frontal and temporal cortices, right cingulate gyrus, right thalamus, and bilateral precuneus.
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“Individuals with MCI and early AD have diminished regional brain uptake of 2-DG, as measured by FDG-PET, before MCI-AD conversion, brain atrophy, or neurodegenerative changes (268, 345, 424, 425, 517).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [268]
In the citing paper
“late-onset, sporadic AD is characterized with an early loss of BBB transporters including GLUT1 transporter for glucose (268, 424, 425, 345, 517)”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [268]
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Metadata
- Authors
- Hunt, A., Schönknecht, P., Henze, M., Seidl, U., Haberkorn, U., & Schröder, J.
- Affiliations
- Heidelberg University (DE)
- German Cancer Research Center (DE)
- Corresponding author
- Schröder, Johannes
- ORCID
- Schröder, Johannes
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 155
- Issue
- 2
- Pages
- 147-154
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2037603765
- Cited by
- 146
- References
- 41
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 16 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 8
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, brain glucose metabolism, mild cognitive impairment, conversion to Alzheimer's disease, precuneus, posterior cingulate cortex, angular gyrus, middle temporal cortex, frontal cortex, thalamus, FDG-PET
- MeSH terms
- Aged, Alzheimer Disease, Brain, Brain Mapping, Cerebral Cortex, Cognition Disorders, Female, Follow-Up Studies, Frontal Lobe, Glucose, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Severity of Illness Index, Temporal Lobe, Tissue Distribution, Disease Progression, Fluorodeoxyglucose F18, Positron-Emission Tomography
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