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Atypical involvement of frontostriatal systems during sensorimotor control in autism
Open accessAbstract
Autism is a neurodevelopmental disorder involving dysmaturation of widely distributed brain systems. Accordingly, behaviors that depend on distributed systems, such as higher level cognition and sensorimotor control, are compromised in the disorder. The current study investigated alterations in neural systems underlying sensorimotor disturbances in autism. An fMRI investigation was conducted using saccadic and pursuit eye movement paradigms with 13 high functioning individuals with autism and 14 age- and IQ-matched typically developing individuals. Individuals with autism had reduced activation in cortical eye fields and cerebellar hemispheres during both eye movement tasks. When executing visually guided saccades, individuals with autism had greater activation bilaterally in a frontostriatal circuit including dorsolateral prefrontal cortex, caudate nucleus, medial thalamus, anterior and posterior cingulate cortex, and right dentate nucleus. The increased activation in prefrontal-striatal-thalamocortical circuitry during visually guided saccades indicates that systems typically dedicated to cognitive control may need to compensate for disturbances in lower-level sensorimotor systems. Reduced activation throughout visual sensorimotor systems may contribute to saccadic and pursuit disturbances that have been reported in autism. These findings document that neurodevelopmental disturbances in autism affect widely distributed brain systems beyond those mediating language and social cognition.
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“FMRI studies of saccades and smooth pursuit document reduced activation within the posterior vermis, and increased involvement of association cortices and dentate nuclei in AD [203].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [203]
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“Regardless of the direction of the aberrant striatal activation (hypo- or hyper-), cortical components of striatal circuits, such as dorsolateral prefrontal cortex, dorsal anterior cingulate cortex, and inferior parietal sulcus, exhibited the same type of aberrant activation (39-41).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [40]
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“Individuals with ASD showed striatal hypoactivation relative to healthy controls in studies of facial expression imitation (39) and cognitive flexibility (40).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [40]
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Metadata
- Authors
- Takarae, Y., Minshew, N. J., Luna, B., & Sweeney, J. A.
- Affiliations
- University of Illinois Chicago (US)
- University of Pittsburgh (US)
- Corresponding author
- Sweeney, John A.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 156
- Issue
- 2
- Pages
- 117-127
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC2180158
- OpenAlex
- W2130594269
- Cited by
- 171
- References
- 52
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 3 · 2021: 15 · 2020: 7 · 2019: 11 · 2018: 3 · 2017: 8 · 2016: 11 · 2015: 10 · 2014: 7 · 2013: 22 · 2012: 9
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NH01433)
- University of Illinois at Chicago
- National Institute of Mental Health (K02MH001433)
- National Institute of Neurological Disorders and Stroke (R01NS033355)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035469, HD35469, U19HD035469)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, sensorimotor control, saccades, smooth pursuit eye movements, frontostriatal circuits, dorsolateral prefrontal cortex, caudate nucleus, thalamus, cingulate cortex, dentate nucleus, cerebellum, cognitive control
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Caudate Nucleus, Cerebellar Nuclei, Corpus Striatum, Dominance, Cerebral, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Oxygen Consumption, Parietal Lobe, Pattern Recognition, Visual, Pursuit, Smooth, Reference Values, Saccades, Thalamus, Prefrontal Cortex, Imaging, Three-Dimensional
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