The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Atypical involvement of frontostriatal systems during sensorimotor control in autism
Open accessAbstract
Autism is a neurodevelopmental disorder involving dysmaturation of widely distributed brain systems. Accordingly, behaviors that depend on distributed systems, such as higher level cognition and sensorimotor control, are compromised in the disorder. The current study investigated alterations in neural systems underlying sensorimotor disturbances in autism. An fMRI investigation was conducted using saccadic and pursuit eye movement paradigms with 13 high functioning individuals with autism and 14 age- and IQ-matched typically developing individuals. Individuals with autism had reduced activation in cortical eye fields and cerebellar hemispheres during both eye movement tasks. When executing visually guided saccades, individuals with autism had greater activation bilaterally in a frontostriatal circuit including dorsolateral prefrontal cortex, caudate nucleus, medial thalamus, anterior and posterior cingulate cortex, and right dentate nucleus. The increased activation in prefrontal-striatal-thalamocortical circuitry during visually guided saccades indicates that systems typically dedicated to cognitive control may need to compensate for disturbances in lower-level sensorimotor systems. Reduced activation throughout visual sensorimotor systems may contribute to saccadic and pursuit disturbances that have been reported in autism. These findings document that neurodevelopmental disturbances in autism affect widely distributed brain systems beyond those mediating language and social cognition.
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“FMRI studies of saccades and smooth pursuit document reduced activation within the posterior vermis, and increased involvement of association cortices and dentate nuclei in AD [203].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [203]
In the citing paper
“Regardless of the direction of the aberrant striatal activation (hypo- or hyper-), cortical components of striatal circuits, such as dorsolateral prefrontal cortex, dorsal anterior cingulate cortex, and inferior parietal sulcus, exhibited the same type of aberrant activation (39-41).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [40]
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“Individuals with ASD showed striatal hypoactivation relative to healthy controls in studies of facial expression imitation (39) and cognitive flexibility (40).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [40]
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Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., & Turner, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5675 · Cited by 4,212
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202
Just, M. A. (2004) · Brain · doi:10.1093/brain/awh199 · Cited by 1,589
Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study
Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., et al. (2001) · Neurology · doi:10.1212/wnl.57.2.245 · Cited by 1,487
Executive dysfunction in autism☆
Hill, E. L. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2003.11.003 · Cited by 1,468
Picard, N., & Strick, P. L. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(01)00266-5 · Cited by 1,184
A clinicopathological study of autism
Bailey, A. (1998) · Brain · doi:10.1093/brain/121.5.889 · Cited by 1,083
Brain structural abnormalities in young children with autism spectrum disorder
Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., Maravilla, K. R., Giedd, J. N., Munson, J., Dawson, G., et al. (2002) · Neurology · doi:10.1212/wnl.59.2.184 · Cited by 961
Minicolumnar pathology in autism
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Neurology · doi:10.1212/wnl.58.3.428 · Cited by 846
Localization of white matter volume increase in autism and developmental language disorder
Herbert, M. R., Ziegler, D. A., Makris, N., Filipek, P. A., Kemper, T. L., Normandin, J. J., Sanders, H. A., Kennedy, D. N., & Caviness, V. S. (2004) · Annals of Neurology · doi:10.1002/ana.20032 · Cited by 663
Age-related performance of human subjects on saccadic eye movement tasks
Munoz, D. P., Broughton, J. R., Goldring, J. E., & Armstrong, I. T. (1998) · Experimental Brain Research · doi:10.1007/s002210050473 · Cited by 656
Cortical motor reorganization in akinetic patients with Parkinson's disease
Sabatini, U., Boulanouar, K., Fabre, N., Martin, F., Carel, C., Colonnese, C., Bozzao, L., Berry, I., Montastruc, J., Chollet, F., et al. (2000) · Brain · doi:10.1093/brain/123.2.394 · Cited by 592
Neuropathology of Infantile Autism
Kemper, T. L., & Bauman, M. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199807000-00001 · Cited by 585
Neuropsychologic functioning in autism: Profile of a complex information processing disorder.
MINSHEW, N. J., GOLDSTEIN, G., & SIEGEL, D. J. (1997) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617797003032 · Cited by 572
Self-citationPositron emission tomography study of voluntary saccadic eye movements and spatial working memory
Sweeney, J. A., Mintun, M. A., Kwee, S. A., Wiseman, M. B., Brown, D. L., Rosenberg, D. R., & Carl, J. R. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.1.454 · Cited by 569
Self-citationRecasting the Smooth Pursuit Eye Movement System
Krauzlis, R. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00801.2003 · Cited by 499
Underdevelopment of the postural control system in autism
Minshew, N. J., Sung, K., Jones, B. L., & Furman, J. M. (2004) · Neurology · doi:10.1212/01.wnl.0000145771.98657.62 · Cited by 440
Self-citationDorsal cortical regions subserving visually guided saccades in humans: an fMRI study
Luna, B. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.1.40 · Cited by 364
Self-citationChanging Brain Networks for Visuomotor Control With Increased Movement Automaticity
Floyer-Lea, A., & Matthews, P. M. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01092.2003 · Cited by 349
Neocortical system abnormalities in autism
Luna, B., Minshew, N. J., Garver, K. E., Lazar, N. A., Thulborn, K. R., Eddy, W. F., & Sweeney, J. A. (2002) · Neurology · doi:10.1212/wnl.59.6.834 · Cited by 344
Self-citationMaturation of executive function in autism
Luna, B., Doll, S. K., Hegedus, S. J., Minshew, N. J., & Sweeney, J. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.030 · Cited by 340
Self-citationOculomotor evidence for neocortical systems but not cerebellar dysfunction in autism
Minshew, N. J., Luna, B., & Sweeney, J. A. (1999) · Neurology · doi:10.1212/wnl.52.5.917 · Cited by 267
Self-citationFunctional anatomy of impaired selective attention and compensatory processing in autism
Belmonte, M. K., & Yurgelun-Todd, D. A. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(03)00189-7 · Cited by 266
DeSouza, J. F. X., Menon, R. S., & Everling, S. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00562.2002 · Cited by 266
Postural Stability in Children with Autism Spectrum Disorder
Molloy, C. A., Dietrich, K. N., & Bhattacharya, A. (2003) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000006001.00667.4c · Cited by 265
Mostofsky, S. H., Goldberg, M. C., Landa, R. J., & DENCKLA, M. B. (2000) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700677020 · Cited by 252
Rinehart, N., Bradshaw, J. L., Brereton, A. V., & Tonge, B. J. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005617831035 · Cited by 249
Proceedings in Computational Statistics
Ziegel, E. R., & Prat, A. (1998) · Technometrics · doi:10.2307/1271203 · Cited by 235
Allen, G., Müller, R., & Courchesne, E. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.005 · Cited by 229
Combining Brains: A Survey of Methods for Statistical Pooling of Information
Lazar, N. A., Luna, B., Sweeney, J. A., & Eddy, W. F. (2002) · NeuroImage · doi:10.1006/nimg.2002.1107 · Cited by 208
Self-citationEffects of Cortical Lesions on Saccadic
Pierrot‐Deseilligny, C., Ploner, C. J., Müri, R. M., Gaymard, B. M., & Rivaud-Péchoux, S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02821.x · Cited by 194
Pursuit eye movement deficits in autism
Takarae, Y. (2004) · Brain · doi:10.1093/brain/awh307 · Cited by 193 · cited 4×
“Smooth pursuit eye movement deficits have been also documented in laboratory studies of individuals with autism (Takarae et al., 2004a).”
BackgroundMethodInfluentialSelf-citationGeneration of smooth-pursuit eye movements: neuronal mechanisms and pathways
Keller, E. L., & Heinen, S. J. (1991) · Neuroscience Research · doi:10.1016/0168-0102(91)90048-4 · Cited by 187
Atypical patterns of cerebral motor activation in autism: a functional magnetic resonance study
Müller, R.-A., Pierce, K., Ambrose, J. B., Allen, G., & Courchesne, E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01004-0 · Cited by 186
Rosano, C., Krisky, C. M., Welling, J. S., Eddy, W. F., Luna, B., Thulborn, K. R., & Sweeney, J. A. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.2.107 · Cited by 182
Self-citationGoldberg, M. C., Lasker, A. G., Zee, D. S., Garth, E., Tien, A., & Landa, R. J. (2002) · Neuropsychologia · doi:10.1016/s0028-3932(02)00059-3 · Cited by 157
van der Geest, J. N., Kemner, C., Camfferman, G., Verbaten, M. N., & van Engeland, H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01070-8 · Cited by 144
Comparison of Memory- and Visually Guided Saccades Using Event-Related fMRI
Brown, M., DeSouza, J. F. X., Goltz, H. C., Ford, K., Menon, R. S., Goodale, M. A., & Everling, S. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00382.2003 · Cited by 115
Oculomotor abnormalities parallel cerebellar histopathology in autism
Takarae, Y. (2004) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.022491 · Cited by 110
Self-citationWessel, K., Zeffiro, T. A., Lou, J., Toro, C., & Hallett, M. (1995) · Brain · doi:10.1093/brain/118.2.379 · Cited by 105
Simó, L. S., Krisky, C. M., & Sweeney, J. A. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi073 · Cited by 95
Self-citationThe Functional Neuroanatomy of Spatial Attention in Autism Spectrum Disorder
Haist, F., Adamo, M., Westerfield, M., Courchesne, E., & Townsend, J. (2005) · Developmental Neuropsychology · doi:10.1207/s15326942dn2703_7 · Cited by 92
Keedy, S., Ebens, C. L., Keshavan, M. S., & Sweeney, J. A. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.01.003 · Cited by 84
Self-citationWhite matter abnormalities in autism detected through transverse relaxation time imaging
Hendry, J., DeVito, T. J., Gelman, N., Densmore, M., Rajakumar, N., Pavlosky, W. F., Williamson, P., Thompson, P. M., Drost, D. J., & Nicolson, R. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.039 · Cited by 76
Functional Imaging Analysis Software — Computational Olio
Eddy, W. F., Fitzgerald, M., Genovese, C. R., Mockus, A., & Noll, D. C. (1996) · COMPSTAT · doi:10.1007/978-3-642-46992-3_4 · Cited by 59
Nitschke, M. F., Binkofski, F., Buccino, G., Posse, S., Erdmann, C., Kömpf, D., Seitz, R. J., & Heide, W. (2004) · Human Brain Mapping · doi:10.1002/hbm.20025 · Cited by 46
Proceedings in Computational Statistics
(1976) · Metrika · doi:10.1007/bf01902863 · Cited by 11
Flagged first, then by citations
Research works printed but not linked: 1
- Filipek, 1992, Morphometric analysis of the brain in developmental language disorders and autism, Annals of Neurology, 32, 475
Cited by
Sorted by citations
Tager‐Flusberg, H., & Kasari, C. (2013) · Autism Research · doi:10.1002/aur.1329 · Cited by 985
Consensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723
Self-citationPsychosis and autism as diametrical disorders of the social brain
Crespi, B. J., & Badcock, C. R. (2008) · Behavioral and Brain Sciences · doi:10.1017/s0140525x08004214 · Cited by 635
Resting state EEG abnormalities in autism spectrum disorders
Wang, J., Barstein, J., Ethridge, L. E., Mosconi, M. W., Takarae, Y., & Sweeney, J. A. (2013) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-5-24 · Cited by 550
Self-citationAberrant Striatal Functional Connectivity in Children with Autism
Di Martino, A., Kelly, C., Grzadzinski, R., Zuo, X.-N., Mennes, M., Mairena, M. A., Lord, C., Castellanos, F. X., & Milham, M. P. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.029 · Cited by 483
Metadata
- Authors
- Takarae, Y., Minshew, N. J., Luna, B., & Sweeney, J. A.
- Affiliations
- University of Illinois Chicago (US)
- University of Pittsburgh (US)
- Corresponding author
- Sweeney, John A.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 156
- Issue
- 2
- Pages
- 117-127
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC2180158
- OpenAlex
- W2130594269
- Cited by
- 171
- References
- 52
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 3 · 2021: 15 · 2020: 7 · 2019: 11 · 2018: 3 · 2017: 8 · 2016: 11 · 2015: 10 · 2014: 7 · 2013: 22 · 2012: 9
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NH01433)
- University of Illinois at Chicago
- National Institute of Mental Health (K02MH001433)
- National Institute of Neurological Disorders and Stroke (R01NS033355)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035469, HD35469, U19HD035469)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, sensorimotor control, saccades, smooth pursuit eye movements, frontostriatal circuits, dorsolateral prefrontal cortex, caudate nucleus, thalamus, cingulate cortex, dentate nucleus, cerebellum, cognitive control
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Caudate Nucleus, Cerebellar Nuclei, Corpus Striatum, Dominance, Cerebral, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Oxygen Consumption, Parietal Lobe, Pattern Recognition, Visual, Pursuit, Smooth, Reference Values, Saccades, Thalamus, Prefrontal Cortex, Imaging, Three-Dimensional
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