The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Atypical involvement of frontostriatal systems during sensorimotor control in autism
Open accessAbstract
Autism is a neurodevelopmental disorder involving dysmaturation of widely distributed brain systems. Accordingly, behaviors that depend on distributed systems, such as higher level cognition and sensorimotor control, are compromised in the disorder. The current study investigated alterations in neural systems underlying sensorimotor disturbances in autism. An fMRI investigation was conducted using saccadic and pursuit eye movement paradigms with 13 high functioning individuals with autism and 14 age- and IQ-matched typically developing individuals. Individuals with autism had reduced activation in cortical eye fields and cerebellar hemispheres during both eye movement tasks. When executing visually guided saccades, individuals with autism had greater activation bilaterally in a frontostriatal circuit including dorsolateral prefrontal cortex, caudate nucleus, medial thalamus, anterior and posterior cingulate cortex, and right dentate nucleus. The increased activation in prefrontal-striatal-thalamocortical circuitry during visually guided saccades indicates that systems typically dedicated to cognitive control may need to compensate for disturbances in lower-level sensorimotor systems. Reduced activation throughout visual sensorimotor systems may contribute to saccadic and pursuit disturbances that have been reported in autism. These findings document that neurodevelopmental disturbances in autism affect widely distributed brain systems beyond those mediating language and social cognition.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“FMRI studies of saccades and smooth pursuit document reduced activation within the posterior vermis, and increased involvement of association cortices and dentate nuclei in AD [203].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [203]
In the citing paper
“Regardless of the direction of the aberrant striatal activation (hypo- or hyper-), cortical components of striatal circuits, such as dorsolateral prefrontal cortex, dorsal anterior cingulate cortex, and inferior parietal sulcus, exhibited the same type of aberrant activation (39-41).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [40]
In the citing paper
“Individuals with ASD showed striatal hypoactivation relative to healthy controls in studies of facial expression imitation (39) and cognitive flexibility (40).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., & Turner, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5675 · Cited by 4,212
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202
Just, M. A. (2004) · Brain · doi:10.1093/brain/awh199 · Cited by 1,589
Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study
Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., et al. (2001) · Neurology · doi:10.1212/wnl.57.2.245 · Cited by 1,487
Executive dysfunction in autism☆
Hill, E. L. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2003.11.003 · Cited by 1,468
Research works printed but not linked: 1
- Filipek, 1992, Morphometric analysis of the brain in developmental language disorders and autism, Annals of Neurology, 32, 475
Cited by
Sorted by citations
Tager‐Flusberg, H., & Kasari, C. (2013) · Autism Research · doi:10.1002/aur.1329 · Cited by 985
Consensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723
Self-citationPsychosis and autism as diametrical disorders of the social brain
Crespi, B. J., & Badcock, C. R. (2008) · Behavioral and Brain Sciences · doi:10.1017/s0140525x08004214 · Cited by 635
Resting state EEG abnormalities in autism spectrum disorders
Wang, J., Barstein, J., Ethridge, L. E., Mosconi, M. W., Takarae, Y., & Sweeney, J. A. (2013) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-5-24 · Cited by 550
Self-citationAberrant Striatal Functional Connectivity in Children with Autism
Di Martino, A., Kelly, C., Grzadzinski, R., Zuo, X.-N., Mennes, M., Mairena, M. A., Lord, C., Castellanos, F. X., & Milham, M. P. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.029 · Cited by 483
Metadata
- Authors
- Takarae, Y., Minshew, N. J., Luna, B., & Sweeney, J. A.
- Affiliations
- University of Illinois Chicago (US)
- University of Pittsburgh (US)
- Corresponding author
- Sweeney, John A.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 156
- Issue
- 2
- Pages
- 117-127
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC2180158
- OpenAlex
- W2130594269
- Cited by
- 171
- References
- 52
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 3 · 2021: 15 · 2020: 7 · 2019: 11 · 2018: 3 · 2017: 8 · 2016: 11 · 2015: 10 · 2014: 7 · 2013: 22 · 2012: 9
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NH01433)
- University of Illinois at Chicago
- National Institute of Mental Health (K02MH001433)
- National Institute of Neurological Disorders and Stroke (R01NS033355)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035469, HD35469, U19HD035469)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, sensorimotor control, saccades, smooth pursuit eye movements, frontostriatal circuits, dorsolateral prefrontal cortex, caudate nucleus, thalamus, cingulate cortex, dentate nucleus, cerebellum, cognitive control
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Caudate Nucleus, Cerebellar Nuclei, Corpus Striatum, Dominance, Cerebral, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Oxygen Consumption, Parietal Lobe, Pattern Recognition, Visual, Pursuit, Smooth, Reference Values, Saccades, Thalamus, Prefrontal Cortex, Imaging, Three-Dimensional
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
