[123I] β-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa
Abstract
Background Impaired serotonin transmission has been implicated in the pathophysiology of eating disorders. We investigated the in vivo availability of brain serotonin transporters and dopamine transporters in bulimia nervosa patients.Methods Approximately 24 hours after injection of [123I]-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([123I] beta-CIT), single photon emission computed tomography scans were performed in 10 medication-free, female bulimic patients and 10 age-matched, healthy females. For quantification of brain serotonin transporter and dopamine transporter availability, a ratio of specific to nonspecific [123I] beta-CIT brain binding was used (V(3)" = target region - cerebellum/cerebellum).Results Drug-free bulimia nervosa patients showed a 17% reduced brain serotonin transporter availability in the hypothalamus and thalamus, as compared with healthy control subjects (2.4 +/- 0.4 vs. 2.9 +/- 0.4, p =.026), and a similar reduction in striatal dopamine transporter availability. There was a negative correlation of illness duration and serotonin transporter availability (r = -.65; p =.042) and a strong positive correlation between hypothalamic/thalamic and striatal V(3)" (r =.80, p <.001).Conclusions This first report of reduced [123I] beta-CIT binding in a relatively small group of patients with bulimia nervosa suggests a reduced hypothalamic and thalamic serotonin transporter availability in bulimia, which is more pronounced with longer duration of illness.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tauscher and colleagues reported a 15% reduction in striatal DAT availability in BN, although the study included only sub-threshold cases and an unmatched control group.
“In the only preliminary study to be published, Tauscher and colleagues [331] reported a 15% reduction in striatal DAT availability in BN, although the study included only sub-threshold cases and an unmatched control group.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [331]
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Structured Clinical Interview for DSM-III-R Personality Disorders
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2012) · PsycTESTS Dataset · doi:10.1037/t07827-000 · Cited by 1,403 · see citing works
Mintun, M. A., Raichle, M. E., Kilbourn, M. R., Wooten, G. F., & Welch, M. J. (1984) · Annals of Neurology · doi:10.1002/ana.410150302 · Cited by 956 · see citing works
Hypothalamic serotonin in control of eating behavior, meal size, and body weight
LEIBOWITZ, S. F., & Alexander, J. T. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00186-3 · Cited by 507 · see citing works
Malison, R. T., Price, L. H., Berman, R., van Dyck, C. H., Pelton, G. H., Carpenter, L., Sanacora, G., Owens, M. J., Nemeroff, C. B., Rajeevan, N., et al. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00272-8 · Cited by 496 · see citing works
Lasa, L., Ayuso‐Mateos, J. L., Vázquez‐Barquero, J. L., Diez-Manrique, F., & Dowrick, C. F. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00088-9 · Cited by 373 · see citing works
Laruelle, M., Baldwin, R. M., Malison, R. T., Zea‐Ponce, Y., Zoghbi, S. S., Al‐Tikeriti, M. S., Sybirska, E. H., Zimmermann, R. C., Wisniewski, G., Neumeyer, J. L., et al. (1993) · Synapse · doi:10.1002/syn.890130402 · Cited by 351 · see citing works
Reduced Central Serotonin Transporters in Alcoholism
Heinz, A., Ragan, P. W., Jones, D. W., Hommer, D. W., Williams, W. A., Knable, M. B., Gorey, J. G., Doty, L., Geyer, C., Lee, K. S., et al. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.11.1544 · Cited by 308 · see citing works
Laruelle, M. A., Wallace, E. A., Seibyl, J. P., Baldwin, R. M., Zea‐Ponce, Y., Zoghbi, S. S., Neumeyer, J. L., Charney, D. S., Hoffer, P. B., & Innis, R. B. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.131 · Cited by 268 · see citing works
Javitch, J. A., Strittmatter, S. M., & Snyder, S. H. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-06-01513.1985 · Cited by 244 · see citing works
Tejani‐Butt, S. M. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11249-4 · Cited by 240 · see citing works
Br�cke, T., Kornhuber, J., Angelberger, P., Asenbaum, S., Frassine, H., & Podreka, I. (1993) · Journal of Neural Transmission · doi:10.1007/bf01245007 · Cited by 199 · see citing works
Self-citationPet study of [11C] β‐CIT binding to monoamine transporters in the monkey and human brain
Farde, L., Halldin, C., Müller, L., Suhara, T., Karlsson, P., & Hall, H. (1994) · Synapse · doi:10.1002/syn.890160203 · Cited by 180 · see citing works
Pirker, W., Asenbaum, S., Hauk, M., Kandlhofer, S., Tauscher, J. T., Willeit, M., Neumeister, A., Praschak-Rieder, N., Angelberger, P., & Brücke, T. (2000) · PubMed · Cited by 180 · see citing works
Self-citationWilleit, M., Praschak-Rieder, N., Neumeister, A., Pirker, W., Asenbaum, S., Vitouch, O., Tauscher, J. T., Hilger, E., Stastny, J., Brücke, T., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00293-0 · Cited by 178 · see citing works
Self-citationHigh affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue
̈m, I. T. B. ̈., ̈m, M. B., & Marcusson, J. O. (1989) · Brain Research · doi:10.1016/0006-8993(89)90511-8 · Cited by 164 · see citing works
Innis, R. B., Baldwin, R. M., Sybirska, E. H., Zea‐Ponce, Y., Laruelle, M., Al‐Tikriti, M. S., Charney, D. S., Zoghbi, S. S., Smith, E. O., Wisniewski, G., et al. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90599-l · Cited by 150 · see citing works
Laruelle, M., Abi-Dargham, A., van Dyck, C., Gil, R. B., D'Souza, D., Krystal, J., Seibyl, J., Baldwin, R., & Innis, R. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00257-7 · Cited by 147 · see citing works
?-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo
Pirker, W., Asenbaum, S., Kasper, S. F., Walter, H., Angelberger, P., Koch, G., Pozzera, A., Deecke, L., Podreka, I., & Br�cke, T. (1995) · Journal of Neural Transmission · doi:10.1007/bf01276462 · Cited by 127 · see citing works
Self-citationStaley, J. K., Basile, M. J., Flynn, D. D., & Mash, D. C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62020549.x · Cited by 114 · see citing works
Decreased Serotonin Function in Bulimia Nervosa
Jimerson, D. C. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830180043005 · Cited by 90 · see citing works
Neumeyer, J. L., Tamagnan, G. D., Wang, S., Gao, Y., Milius, R. A., Kula, N. S., & Baldessarini, R. J. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm9505324 · Cited by 87 · see citing works
Kuikka, J. T., Bergstr�m, K. A., Vanninen, E. J., et al. (1993) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00180909 · Cited by 77 · see citing works
Effects of acute tryptophan depletion on mood in bulimia nervosa
Kaye, W. H., Gendall, K. A., Fernstrom, M. H., Fernstrom, J. D., McConaha, C. W., & Weltzin, T. E. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00108-0 · Cited by 61 · see citing works
In vivo visualization of serotonin transporters in the human brain during fluoxetine treatment
Tauscher, J. T., Pirker, W., de Zwaan, M., Asenbaum, S., Brücke, T., & Kasper, S. F. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(98)00013-3 · Cited by 56 · see citing works
Self-citationPlatelet serotonin uptake in bulimia nervosa
Goldbloom, D. S., Hicks, L. K., & Garfinkel, P. E. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90404-p · Cited by 38 · see citing works
Pharmacotherapy of bulimia nervosa-experience with fluoxetine
Wood, A. (1993) · International Clinical Psychopharmacology · doi:10.1097/00004850-199300840-00014 · Cited by 24 · see citing works
Neumeyer, J. L., Tamagnan, G. D., Wang, S., GAO, Y., Milius, R. A., Kula, N., & Baldessarini, R. J. (1996) · ChemInform · doi:10.1002/chin.199619250 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Deficient Activity in the Neural Systems That Mediate Self-regulatory Control in Bulimia Nervosa
Marsh, R., Steinglass, J. E., Gerber, A. J., Graziano O’Leary, K., Wang, Z., Murphy, D., Walsh, B. T., & Peterson, B. S. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.504 · Cited by 190 · see citing works
Serotonin alterations in anorexia and bulimia nervosa: New insights from imaging studies
KAYE, W., FRANK, G., BAILER, U., HENRY, S., MELTZER, C., PRICE, J., MATHIS, C., & WAGNER, A. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.04.013 · Cited by 181 · see citing works
Self-citationThe serotonin transporter in psychiatric disorders: insights from PET imaging
Spies, M., Knudsen, G. M., Lanzenberger, R., & Kasper, S. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00232-1 · Cited by 177 · see citing works
Self-citationBailer, U. F., Frank, G. K., Henry, S. E., Price, J. C., Meltzer, C. C., Weissfeld, L., Mathis, C. A., Drevets, W. C., Wagner, A., Hoge, J., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.9.1032 · Cited by 182 · see citing works
Self-citationAdvances from neuroimaging studies in eating disorders
Frank, G. K. W. (2015) · CNS Spectrums · doi:10.1017/s1092852915000012 · Cited by 144 · see citing works
Neuroimaging Studies in Eating Disorders
Frank, G. K., Bailer, U. F., Henry, S., Wagner, A., & Kaye, W. H. (2004) · CNS Spectrums · doi:10.1017/s1092852900009639 · Cited by 94 · see citing works
Self-citationHerold, N., Uebelhack, K., Franke, L., Amthauer, H., Luedemann, L., Bruhn, H., Felix, R., Uebelhack, R., & Plotkin, M. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-005-0429-7 · Cited by 61 · see citing works
Lundgren, J. D., Newberg, A. B., Allison, K. C., Wintering, N. A., Ploessl, K., & Stunkard, A. J. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.07.006 · Cited by 55 · see citing works
From Disordered Eating to Addiction: The “Food Drug” in Bulimia Nervosa
Umberg, E. N., Shader, R. I., Hsu, L. K. G., & Greenblatt, D. J. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318252464f · Cited by 52 · see citing works
Bulimia nervosa and evidence for striatal dopamine dysregulation: A conceptual review
Broft, A. I., Berner, L. A., Martinez, D., & Walsh, B. T. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.028 · Cited by 34 · see citing works
Self-Regulatory Control and Habit Learning in the Development of Eating Disorders
Marsh, R., Steinglass, J., Graziano, K., Peterson, B., & Walsh, B. T. (2007) · Current Psychiatry Reviews · doi:10.2174/157340007779815691 · Cited by 8 · see citing works
- Authors
- Tauscher, J., Pirker, W., Willeit, M., de Zwaan, M., Bailer, U., Neumeister, A., Asenbaum, S., Lennkh, C., Praschak-Rieder, N., Brücke, T., & Kasper, S.
- Affiliations
- University of Vienna (AT)
- Wilhelminen Hospital (AT)
- Corresponding author
- Tauscher, Johannes
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 49
- Issue
- 4
- Pages
- 326-332
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2078043779
- Cited by
- 134
- References
- 28
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 8 · 2013: 4 · 2012: 11
- FWCI
- 11.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- bulimia nervosa, serotonin transporter, dopamine transporter, [123I]beta-CIT, SPECT imaging, hypothalamus, thalamus, striatum, disease duration, eating disorders, serotonin transmission
- MeSH terms
- Adolescent, Adult, Binding, Competitive, Biological Transport, Active, Brain, Bulimia, Carrier Proteins, Cerebellum, Depression, Female, Humans, Serotonin, Tomography, Emission-Computed, Single-Photon, Cognitive Behavioral Therapy, Radiopharmaceuticals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review