Cited by 134Eating Disorders and BehaviorsNeurotransmitter Receptor Influence on BehaviorRegulation of Appetite and Obesity

[123I] β-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa

Tauscher, Johannes, Pirker, Walter, Willeit, Matthäus, de Zwaan, Martina, Bailer, Ursula, Neumeister, Alexander, Asenbaum, Susanne, Lennkh, Claudia +3 more·2001·Biological Psychiatry

Abstract

Background Impaired serotonin transmission has been implicated in the pathophysiology of eating disorders. We investigated the in vivo availability of brain serotonin transporters and dopamine transporters in bulimia nervosa patients.Methods Approximately 24 hours after injection of [123I]-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([123I] beta-CIT), single photon emission computed tomography scans were performed in 10 medication-free, female bulimic patients and 10 age-matched, healthy females. For quantification of brain serotonin transporter and dopamine transporter availability, a ratio of specific to nonspecific [123I] beta-CIT brain binding was used (V(3)" = target region - cerebellum/cerebellum).Results Drug-free bulimia nervosa patients showed a 17% reduced brain serotonin transporter availability in the hypothalamus and thalamus, as compared with healthy control subjects (2.4 +/- 0.4 vs. 2.9 +/- 0.4, p =.026), and a similar reduction in striatal dopamine transporter availability. There was a negative correlation of illness duration and serotonin transporter availability (r = -.65; p =.042) and a strong positive correlation between hypothalamic/thalamic and striatal V(3)" (r =.80, p <.001).Conclusions This first report of reduced [123I] beta-CIT binding in a relatively small group of patients with bulimia nervosa suggests a reduced hypothalamic and thalamic serotonin transporter availability in bulimia, which is more pronounced with longer duration of illness.

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Crossref · 10.1016/s0006-3223(00)00951-3

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Authors
Tauscher, J., Pirker, W., Willeit, M., de Zwaan, M., Bailer, U., Neumeister, A., Asenbaum, S., Lennkh, C., Praschak-Rieder, N., Brücke, T., & Kasper, S.
Affiliations
  • University of Vienna (AT)
  • Wilhelminen Hospital (AT)
Corresponding author
Tauscher, Johannes
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2001-02
Volume
49
Issue
4
Pages
326-332
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2078043779
Cited by
134
References
28
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 8 · 2013: 4 · 2012: 11
FWCI
11.56
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
bulimia nervosa, serotonin transporter, dopamine transporter, [123I]beta-CIT, SPECT imaging, hypothalamus, thalamus, striatum, disease duration, eating disorders, serotonin transmission
MeSH terms
Adolescent, Adult, Binding, Competitive, Biological Transport, Active, Brain, Bulimia, Carrier Proteins, Cerebellum, Depression, Female, Humans, Serotonin, Tomography, Emission-Computed, Single-Photon, Cognitive Behavioral Therapy, Radiopharmaceuticals

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