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Cited by 125Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 70 of the 73 references it cites were found in a registry or an index.

Abnormal recruitment of working memory updating networks during maintenance of trauma-neutral information in post-traumatic stress disorder

Moores, Kathryn A., Clark, C. Richard, McFarlane, Alexander C., Brown, Greg C., Puce, Aina, Taylor, D. James·2008·Psychiatry Research: Neuroimaging
DOI 10.1016/j.pscychresns.2007.08.011
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Abstract

Post-traumatic stress disorder (PTSD) is characterised by disturbances in concentration and memory, symptoms which are a source of further distress for patients. Related to this, abnormalities in underlying working memory (WM) systems have been identified [Clark, C.R., McFarlane, A.C., Morris, P., Weber, D.L., Sonkkilla, C., Shaw, M.E., Marcina, J., Tochon-Danguy, H.J., Egan, G.F., 2003. Cerebral function in posttraumatic stress disorder during verbal working memory updating: a positron emission tomography study. Biological Psychiatry 53, 474-481.], indicating dysfunction in left hemisphere brain regions. In this study, we performed functional magnetic resonance imaging (fMRI) in 13 patients with severe PTSD and matched non-traumatized Controls, during performance of visuo-verbal tasks that involved either maintenance or continual updating of word stimuli in WM. The PTSD group failed to show differential activation during WM updating, and instead appeared to show abnormal recruitment of WM updating network regions during WM maintenance. These regions included the bilateral dorsolateral prefrontal cortex (DLPFC) and the inferior parietal lobe (IPL). Several other regions were significantly more activated in Controls than in PTSD during WM updating, including the hippocampus, the anterior cingulate (AC), and the brainstem pons, key regions that are consistently implicated in the neurobiology of PTSD. These findings suggest compensatory recruitment of networks in PTSD normally only deployed during updating of WM and may reflect PTSD patients' difficulty engaging with their day-to-day environment.

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Metadata

Authors
Moores, K. A., Clark, C. R., McFarlane, A. C., Brown, G. C., Puce, A., & Taylor, D. J.
Affiliations
  • Flinders University (AU)
  • The University of Adelaide (AU)
  • West Virginia University (US)
  • Royal Adelaide Hospital (AU)
Corresponding author
Clark, C. Richard
ORCID
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2008-07
Volume
163
Issue
2
Pages
156-170
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2007.08.011
OpenAlex
W1968696218
Cited by
125
References
73
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 10 · 2015: 5 · 2014: 13 · 2013: 10 · 2012: 10
FWCI
11.50
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • Flinders Academic Commons (Flinders University) (submittedVersion)
Funders
  • Medical Research Council
  • Australian Research Council
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
post-traumatic stress disorder, working memory, memory updating, memory maintenance, dorsolateral prefrontal cortex, inferior parietal lobule, hippocampus, anterior cingulate cortex, compensatory neural recruitment
MeSH terms
Adult, Attention, Brain, Brain Mapping, Dominance, Cerebral, Female, Gyrus Cinguli, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Nerve Net, Parietal Lobe, Pons, Psychomotor Performance, Recruitment, Neurophysiological, Semantics, Stress Disorders, Post-Traumatic, Verbal Learning, Prefrontal Cortex, Imaging, Three-Dimensional, Positron-Emission Tomography

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