Cerebral function in posttraumatic stress disorder during verbal working memory updating: a positron emission tomography study
Abstract
Background This study examined cerebral function in posttraumatic stress disorder (PTSD) during the updating of working memory to trauma-neutral, verbal information. Methods Ten PTSD and matched control subjects completed a visuoverbal target detection task involving continuous updating (Variable target condition) or no updating (Fixed target condition) of target identity, with updating activity estimated by condition comparison. Results Normal updating activity using this paradigm involved bilateral activation of the dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobe. The PTSD group lacked this activation in the left hemisphere and was significantly different from control subjects in this regard, but showed additional activation in the superior parietal lobe, bilaterally. Conclusions The pattern of parietal activation suggests a dependence on visuospatial coding for working memory representation of trauma-neutral, verbal information. Group differences in the relative involvement of the DLPFC indicate less dependence in PTSD on the executive role normally attributed to the left DLPFC for monitoring and manipulation of working memory content in posterior regions of the brain.
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Other studies have observed no difference in amygdala activity between subjects with PTSD and control groups without the disorder.
“However, others have observed no difference between a group of subjects with PTSD and control groups consisting of subjects without the disorder (Clark et al., 2002;Ganzel et al., 2008;Shin et al., 2001).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Clark et al., 2002
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- Authors
- Clark, C. R., McFarlane, A. C., Morris, P., Weber, D. L., Sonkkilla, C., Shaw, M., Marcina, J., Tochon-Danguy, H. J., & Egan, G. F.
- Affiliations
- Flinders University (AU)
- The University of Adelaide (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- The University of Melbourne (AU)
- Corresponding author
- Clark, C.Richard
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 53
- Issue
- 6
- Pages
- 474-481
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2142184494
- Cited by
- 162
- References
- 3
- Citations by year
- 2026: 2 · 2025: 37 · 2024: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 2 · 2012: 6
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, verbal working memory, working memory updating, dorsolateral prefrontal cortex, inferior parietal lobule, superior parietal lobule, hemispheric lateralization, executive function, brain activation
- MeSH terms
- Female, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Parietal Lobe, Severity of Illness Index, Stress Disorders, Post-Traumatic, Tomography, Emission-Computed, Visual Perception, Prefrontal Cortex
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