Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder
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In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.
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A magnetic resonance spectroscopy study showed an association between GRIN2B polymorphisms and glutamatergic concentrations in anterior cingulate cortex of OCD patients.
“a magnetic resonance spectroscopy study showing an association between GRIN2B polymorphisms and glutamatergic concentrations in anterior cingulate cortex (ACC) of OCD patients 30”
From DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS: Review: Dissecting OCD Circuits: Animals to Treatments (2015) · cites this paper as [30]
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- Authors
- Arnold, P. D., MacMaster, F. P., Richter, M. A., Hanna, G. L., Sicard, T., Burroughs, E., Mirza, Y., Easter, P. C., Rose, M., Kennedy, J. L., & Rosenberg, D. R.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Wayne State University (US)
- University of Michigan (US)
- Corresponding author
- Arnold, Paul Daniel
- ORCID
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 172
- Issue
- 2
- Pages
- 136-139
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC2670773
- OpenAlex
- W2010479278
- Cited by
- 91
- References
- 29
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 9 · 2014: 3 · 2013: 10 · 2012: 11
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Yale University
- Centre for Addiction and Mental Health
- National Institute of Mental Health (K24MH02037, R01 MH 59299, K24MH002037, R01MH085300, R01MH059299)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- NR2B subunit, NMDA receptor, glutamate receptor genes, obsessive-compulsive disorder, pediatric OCD, anterior cingulate cortex, glutamate, genetic polymorphism, glutamatergic neurotransmission, candidate gene association
- MeSH terms
- Adolescent, Age Factors, Brain, Child, Female, Genotype, Gyrus Cinguli, Humans, Male, Magnetic Resonance Spectroscopy, Obsessive-Compulsive Disorder, Occipital Lobe, Polymorphism, Genetic, Genetic Variation, Receptors, N-Methyl-D-Aspartate, Glutamic Acid
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