Cited by 91Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder

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Arnold, Paul Daniel, MacMaster, Frank P., Richter, Margaret A., Hanna, Gregory L., Sicard, Tricia, Burroughs, Eliza, Mirza, Yousha, Easter, Phillip C. +3 more·2009·Psychiatry Research: Neuroimaging

Abstract

In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.

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Crossref · 10.1016/j.pscychresns.2009.02.005

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  1. Arnold PD 2007 Glutamate genes in obsessive-compulsive disorder including childhood onset cases and neuroimaging PhD Dissertation University of Toronto Toronto

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Authors
Arnold, P. D., MacMaster, F. P., Richter, M. A., Hanna, G. L., Sicard, T., Burroughs, E., Mirza, Y., Easter, P. C., Rose, M., Kennedy, J. L., & Rosenberg, D. R.
Affiliations
  • Centre for Addiction and Mental Health (CA)
  • Wayne State University (US)
  • University of Michigan (US)
Corresponding author
Arnold, Paul Daniel
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2009-05
Volume
172
Issue
2
Pages
136-139
ISSN
0925-4927 (ISSN-L)
OpenAlex
W2010479278
Cited by
91
References
29
Citations by year
2026: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 9 · 2014: 3 · 2013: 10 · 2012: 11
FWCI
12.71
Type
journal article
Language
en
Open access
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Yale University
  • Centre for Addiction and Mental Health
  • National Institute of Mental Health (K24MH02037, R01 MH 59299, K24MH002037, R01MH085300, R01MH059299)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
NR2B subunit, NMDA receptor, glutamate receptor genes, obsessive-compulsive disorder, pediatric OCD, anterior cingulate cortex, glutamate, genetic polymorphism, glutamatergic neurotransmission, candidate gene association
MeSH terms
Adolescent, Age Factors, Brain, Child, Female, Genotype, Gyrus Cinguli, Humans, Male, Magnetic Resonance Spectroscopy, Obsessive-Compulsive Disorder, Occipital Lobe, Polymorphism, Genetic, Genetic Variation, Receptors, N-Methyl-D-Aspartate, Glutamic Acid

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