The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The functional neuroanatomy of mental pain in depression
Abstract
This study aimed at determining the functional neuroanatomy of mental pain, a hitherto neglected symptom in the study of depression, which according to DSM-IV is stronglylinked with suicide. Mental pain (measured with the Orbach & Mikulincer Mental Pain Scale), suicidal ideation (measured using the Hamilton Rating Scale for Depression), hopelessness (measured using Beck's Hopelessness Scale), and regional cerebral blood flow as measured with single photon emission computed tomography were assessed in 39 depressed individuals. Levels of mental pain were significantly and positively associated with suicidal ideation and levels of hopelessness. When compared with patients with low levels of mental pain, those with high levels of mental pain showed relatively increased perfusion in the right dorsolateral prefrontal cortex, occipital cortex and inferior frontal gyrus and in the left inferior temporal gyrus, and relatively decreased perfusion at the medulla. The findings indicate that mental pain in depressed patients is associated with an increased risk of suicide and that high levels of mental pain are associated with changes in perfusion in brain areas that are involved in the regulation of emotions. Further study is warranted to understand whether this association reflects increased emotional processing or decreased cognitive control over mental pain in depressed individuals.
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In the citing paper
“It was chosen because psychological pain measured by this instrument is dissociable from the negative emotions related to depressive and anxiety disorders and is specifically associated with suicidality.8,11”
From “Nothing Hurts Less Than Being Dead”: Psychological Pain in Case Descriptions of Psychiatric Euthanasia and Assisted Suicide from the Netherlands: « Rien ne fait moins mal qu’être mort »: La douleur psychologique dans les descriptions de cas d’euthanasie et de suicide assisté psychiatrique aux Pays-Bas (2020) · cites this paper as [11]
In the citing paper
“Psychological pain describes a widely accepted transdiagnostic dimension9 with specific neurobiological bases10,11 and validated measurement tools.8,12”
From “Nothing Hurts Less Than Being Dead”: Psychological Pain in Case Descriptions of Psychiatric Euthanasia and Assisted Suicide from the Netherlands: « Rien ne fait moins mal qu’être mort »: La douleur psychologique dans les descriptions de cas d’euthanasie et de suicide assisté psychiatrique aux Pays-Bas (2020) · cites this paper as [11]
In the citing paper
“In this study, mental pain was associated with change in brain areas involved in emotional processing [18].”
From High depression symptomatology and mental pain characterize suicidal psychiatric patients (2022) · cites this paper as [18]
Citations
Cites
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Mental Pain: A Multidimensional Operationalization and Definition
Orbach, I., Mikulincer, M., Sirota, P., & Gilboa‐Schechtman, E. (2003) · Suicide and Life-Threatening Behavior · doi:10.1521/suli.33.3.219.23219 · Cited by 257
Fitzgerald, P. B., Oxley, T. J., Laird, A. R., Kulkarni, J., Egan, G. F., & Daskalakis, Z. J. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.04.006 · Cited by 254
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Olié, É., Clain, G., Malestroit, M., Fiedos, D., Cognasse, F., Deverdun, J., Bars, E. L., & Courtet, P. (2023) · Research Square · doi:10.21203/rs.3.rs-2669073/v1
Bahat-Yaacoby, A., & Hamdan, S. (2024) · Death Studies · doi:10.1080/07481187.2024.2400372 · Cited by 1
“However, current literature suggests that while they overlap, these emotional states are distinct and separable (DeLisle & Holden, 2009; Meerwijk & Weiss, 2011; Van Heeringen et al., 2010).”
Gimelfarb, Y., & Cojocaru, D. (2024) · Educatia 21 · doi:10.24193/ed21.2024.28.34 · Cited by 1
fMRI features in recent suicide attempters performing the future imagination task
Esmaeil-Zadeh, M., Fattahi, M., Rasouli, N., Hamid Soltanian-zadeh, A., Sisara, M. A., Rajab, E., Jafari-Mehdiabad, A., & Malakouti, S. K. (2025) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2025.112049
Liu, Q., Ma, H., Li, J., Chen, M., Zhang, Y., Tang, Z., Du, X., & Ye, G. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07674-7
“Kees van Heeringen et al. [53] identified that a greater risk of suicide was linked to alterations in brain regions responsible for the cognitive regulation of emotions in adults with depression.”
Douleur psychologique et exclusion sociale dans les conduites suicidaires
Olié, É. (2014) · theses.fr (ABES) · doi:10.70675/657d26f9zdfd9z495ez8d2az0095d5ba2816
Conejero, I. (2020) · theses.fr (ABES) · doi:10.70675/e0cb59ecz80a8z4338za3ddz2ea8e8d0334d
Boissard, É. (2023) · theses.fr (ABES) · doi:10.70675/95d775e5z6b0ez44c6z8f63z6473f8f6f430
Shahine, M., Malestroit, M., Courtet, P., & Olié, É. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08068-z
Functional Brain Imaging of Suicidal Behavior
Desmyter, S., Bijttebier, S., & Heeringen, C. V. (2014) · Springer eBooks · doi:10.1007/978-3-642-40384-2_6
Metadata
- Authors
- van Heeringen, K., Van den Abbeele, D., Vervaet, M., Soenen, L., & Audenaert, K.
- Affiliations
- Ghent University Hospital (BE)
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 181
- Issue
- 2
- Pages
- 141-144
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2151215130
- Cited by
- 113
- References
- 16
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 20 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 6
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- psychological suffering, depression, suicidal ideation, hopelessness, regional cerebral blood flow, dorsolateral prefrontal cortex, inferior frontal gyrus, inferior temporal gyrus, medulla, emotion regulation, suicide risk
- MeSH terms
- Adolescent, Adult, Aged, Brain Mapping, Cysteine, Depression, Female, Humans, Functional Laterality, Male, Middle Aged, Pain, Psychiatric Status Rating Scales, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Young Adult
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