The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The functional neuroanatomy of mental pain in depression
Abstract
This study aimed at determining the functional neuroanatomy of mental pain, a hitherto neglected symptom in the study of depression, which according to DSM-IV is stronglylinked with suicide. Mental pain (measured with the Orbach & Mikulincer Mental Pain Scale), suicidal ideation (measured using the Hamilton Rating Scale for Depression), hopelessness (measured using Beck's Hopelessness Scale), and regional cerebral blood flow as measured with single photon emission computed tomography were assessed in 39 depressed individuals. Levels of mental pain were significantly and positively associated with suicidal ideation and levels of hopelessness. When compared with patients with low levels of mental pain, those with high levels of mental pain showed relatively increased perfusion in the right dorsolateral prefrontal cortex, occipital cortex and inferior frontal gyrus and in the left inferior temporal gyrus, and relatively decreased perfusion at the medulla. The findings indicate that mental pain in depressed patients is associated with an increased risk of suicide and that high levels of mental pain are associated with changes in perfusion in brain areas that are involved in the regulation of emotions. Further study is warranted to understand whether this association reflects increased emotional processing or decreased cognitive control over mental pain in depressed individuals.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It was chosen because psychological pain measured by this instrument is dissociable from the negative emotions related to depressive and anxiety disorders and is specifically associated with suicidality.8,11”
From “Nothing Hurts Less Than Being Dead”: Psychological Pain in Case Descriptions of Psychiatric Euthanasia and Assisted Suicide from the Netherlands: « Rien ne fait moins mal qu’être mort »: La douleur psychologique dans les descriptions de cas d’euthanasie et de suicide assisté psychiatrique aux Pays-Bas (2020) · cites this paper as [11]
In the citing paper
“Psychological pain describes a widely accepted transdiagnostic dimension9 with specific neurobiological bases10,11 and validated measurement tools.8,12”
From “Nothing Hurts Less Than Being Dead”: Psychological Pain in Case Descriptions of Psychiatric Euthanasia and Assisted Suicide from the Netherlands: « Rien ne fait moins mal qu’être mort »: La douleur psychologique dans les descriptions de cas d’euthanasie et de suicide assisté psychiatrique aux Pays-Bas (2020) · cites this paper as [11]
In the citing paper
“In this study, mental pain was associated with change in brain areas involved in emotional processing [18].”
From High depression symptomatology and mental pain characterize suicidal psychiatric patients (2022) · cites this paper as [18]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Does Rejection Hurt? An fMRI Study of Social Exclusion
Eisenberger, N. I., Lieberman, M. D., & Williams, K. D. (2003) · Science · doi:10.1126/science.1089134 · Cited by 3,849
Why Does Social Exclusion Hurt? The Relationship Between Social and Physical Pain.
MacDonald, G., & Leary, M. R. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.2.202 · Cited by 1,712
Why rejection hurts: a common neural alarm system for physical and social pain
Eisenberger, N. I., & Lieberman, M. D. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.05.010 · Cited by 1,246
Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings
Leppänen, J. M. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000191500.46411.00 · Cited by 632
Diagnostic and Statistical Manual of Mental Disorders
Salkind, N. J. (2005) · Encyclopedia of Human Development · doi:10.4135/9781412952484.n193 · Cited by 467
Shneidman, E. S. (1996) · Medical Entomology and Zoology · Cited by 363
Wagner, G., Sinsel, E., Sobanski, T., Köhler, S., Marinou, V., Mentzel, H.-J., Sauer, H., & Schlösser, R. G. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.025 · Cited by 278
Mental Pain: A Multidimensional Operationalization and Definition
Orbach, I., Mikulincer, M., Sirota, P., & Gilboa‐Schechtman, E. (2003) · Suicide and Life-Threatening Behavior · doi:10.1521/suli.33.3.219.23219 · Cited by 257
Fitzgerald, P. B., Oxley, T. J., Laird, A. R., Kulkarni, J., Egan, G. F., & Daskalakis, Z. J. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.04.006 · Cited by 254
Cited by
Sorted by citations
van Heeringen, K., & Mann, J. J. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)70220-2 · Cited by 550
The suicidal mind and brain: A review of neuropsychological and neuroimaging studies
Jollant, F., Lawrence, N. L., Olié, E., Guillaume, S., & Courtet, P. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.556200 · Cited by 363
Mental Pain and Suicide: A Systematic Review of the Literature
Verrocchio, M. C., Carrozzino, D., Marchetti, D., Andreasson, K., Fulcheri, M., & Bech, P. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00108 · Cited by 297
“In other terms, the results indicate that levels of mental pain are associated with an increased risk of suicide, independently from the severity of depressive condition (25).”
BackgroundMeerwijk, E. L., Ford, J. M., & Weiss, S. J. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9179-y · Cited by 238
“Both studies used the Orbach & Mikulincer Mental Pain questionnaire to assess psychological pain, which has been shown to be reliable and have a high degree of validity (Orbach et al. 2003b; Soumani et al. 2011; van Heeringen et al. 2010).”
BackgroundMethodResultInfluentialStructural and functional neuroimaging studies of the suicidal brain
Desmyter, S., Heeringen, C. V., & Audenaert, K. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.026 · Cited by 216
Self-citation
Metadata
- Authors
- van Heeringen, K., Van den Abbeele, D., Vervaet, M., Soenen, L., & Audenaert, K.
- Affiliations
- Ghent University Hospital (BE)
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 181
- Issue
- 2
- Pages
- 141-144
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2151215130
- Cited by
- 113
- References
- 16
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 20 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 6
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- psychological suffering, depression, suicidal ideation, hopelessness, regional cerebral blood flow, dorsolateral prefrontal cortex, inferior frontal gyrus, inferior temporal gyrus, medulla, emotion regulation, suicide risk
- MeSH terms
- Adolescent, Adult, Aged, Brain Mapping, Cysteine, Depression, Female, Humans, Functional Laterality, Male, Middle Aged, Pain, Psychiatric Status Rating Scales, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
