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Cited by 254Transcranial Magnetic Stimulation StudiesTreatment of Major DepressionNeural and Behavioral Psychology Studies

An analysis of functional neuroimaging studies of dorsolateral prefrontal cortical activity in depression

Fitzgerald, Paul B., Oxley, Tom J., Laird, Angela R., Kulkarni, Jayashri, Egan, Gary F., Daskalakis, Zafiris J.·2006·Psychiatry Research Neuroimaging
DOI 10.1016/j.pscychresns.2006.04.006
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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is currently undergoing active investigation for use in the treatment of major depression. Recent research has indicated that current methods used to localize the site of stimulation in dorsolateral prefrontal cortex (DLPFC) are significantly inaccurate. However, little information is available on which to base a choice of stimulation site. The aim of the current study was to systematically examine imaging studies in depression to attempt to identify whether there is a pattern of imaging results that suggests an optimal site of stimulation localization. We analysed all imaging studies published prior to 2005 that examined patients with major depression. Studies reporting activation in DLPFC were identified. The DLPFC regions identified in these studies were analysed using the Talairach and Rajkowska-Goldman-Rakic coordinate systems. In addition, we conducted a quantitative meta-analysis of resting studies and studies of serotonin reuptake inhibitor antidepressant treatment. There was considerable heterogeneity in the results between studies. Changes in Brodmann area 9 were relatively consistently identified in resting, cognitive activation and treatment studies included in the meta-analysis. However, there was little consistency in the direction of these changes or the hemisphere in which they were identified. At this stage, the results of imaging studies published to date have limited capacity to inform the choice of optimal prefrontal cortical region for the use in rTMS treatment studies.

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  • Involvement of the PFC in affective disorders may be complex and not attributable to a single region.

    “which suggests involvement of the PFC in affective disorders may be complex and not attributable to a single region (Fitzgerald et al., 2006; Thomas and Elliott, 2009).”

    From Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety (2018) · cites this paper as Fitzgerald et al., 2006

  • The regional changes correlate well with abnormal fMRI responses (hypoactivation of the dorsolateral prefrontal cortex during working memory updating and during conscious negative emotion processing) seen in the authors' previous analysis of fMRI data from this sample and in other studies.

    “The regional changes correlate well with the abnormal fMRI responses (hypoactivation of the dorsolateral prefrontal cortex during working memory updating and during conscious negative emotion processing) seen in our previous analysis of fMRI data from this sample (Korgaonkar et al., 2013) and also seen in other studies (Fitzgerald et al., 2006).”

    From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Fitzgerald et al., 2006

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Authors
Fitzgerald, P. B., Oxley, T. J., Laird, A. R., Kulkarni, J., Egan, G. F., & Daskalakis, Z. J.
Affiliations
  • The Alfred Hospital (AU)
  • The University of Texas at San Antonio Health Science Center (US)
  • The University of Melbourne (AU)
  • Centre for Addiction and Mental Health (CA)
Corresponding author
Fitzgerald, Paul B.
ORCID
Venue
Psychiatry Research Neuroimaging
Publisher
Elsevier BV
Published
2006-11
Volume
148
Issue
1
Pages
33-45
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2006.04.006
OpenAlex
W2047425155
Cited by
254
References
68
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 15 · 2021: 14 · 2020: 6 · 2019: 12 · 2018: 9 · 2017: 16 · 2016: 15 · 2015: 15 · 2014: 20 · 2013: 22 · 2012: 15
FWCI
7.71
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institutes of Health Research
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
major depressive disorder, dorsolateral prefrontal cortex, repetitive transcranial magnetic stimulation, Brodmann area 9, resting-state brain activity, serotonin reuptake inhibitors, antidepressant response
MeSH terms
Antidepressive Agents, Brain Mapping, Major Depressive Disorder, Humans, Magnetic Resonance Imaging, Tomography, Emission-Computed, Single-Photon, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Prefrontal Cortex, Positron-Emission Tomography, Transcranial Magnetic Stimulation

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