The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Amygdala hyperreactivity in restrictive anorexia nervosa
Abstract
Functional imaging studies had often investigated heterogeneous samples of anorexia nervosa (AN) patients with varying paradigms and methodologies that had resulted in divergent results. The present study aimed to examine these issues by studying a well-defined sample of restrictive AN patients with a disorder-specific paradigm which had been used previously. Subjects showed increased blood oxygen level dependent responses of the cingulate, frontal, insular and parietal cortices. Group comparisons demonstrated increased activity of the right amygdala in the sample of restrictive AN patients. Our results are in support of other recently published functional imaging studies and point to a pivotal role of the right amygdala in AN. Signals of the midcingulum were reduced in comparison to healthy controls. The constellation of increased activity of the amygdala and decreased activity of the cingulate cortex likely represents parts of a negative feedback loop of emotional processing. Disgust ratings correlated with the amygdala signal negatively, which points to the complex role of this structure within eating disorders.
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“Several studies have reported reduced reward motivation for food rewards in eating disorders.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [321]
In the citing paper
“Joos and colleagues [321] found reduced activation of the ACC in individuals with concurrent BN during the presentation of visual food cues”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [321]
Citations
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Items 101–123 of 123
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Disgust drivers do not impact on the altered body in action representation in anorexia nervosa
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“So, even though they explicitly describe themselves as more susceptible to disgust triggers, in line with other studies (Aharoni & Hertz, 2012; Haidt et al., 1994; Joos et al., 2011; Troop et al., 2002), this account does not mirror their behaviour in the experimental task.”
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“The affective and addictive aspects of AN pathophysiology are related to the activity of the brain, limbic and amygdala pathways (Burkert et al., 2019; Chowdhury et al., 2003; Joos et al., 2011; Lipsman et al., 2015; Burkert et al., 2019), in which 5-HT2A may also play an important role.”
Appetite Regulation and Motivation to Eat in Eating Disorders
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“In patients with AN, the volume of several amygdala nuclei were reduced [53] and its activity is increased and correlated to the feeling of disgust [54].”
Mundorf, A., Siebert, A., von der Assen, C., Brünahl, C., & Peterburs, J. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2026.1844251
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Loizou, P., Kaimakami, S., Tomazou, A., Panayiotou, G., Zanos, P., Junghöfer, M., & Paraskevopoulos, E. (2026) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2026.1912696
“Food-related motivation in AN is increasingly conceptualized as a multifaceted construct encompassing cognitive, emotional, and reward-related processes (Godier et al., 2016; Joos et al., 2011; Paslakis et al., 2016; Scharner and Stengel, 2019).”
How Diagnostic Terms may Catalyze or Extend the Duration of Anorexia Nervosa
Pyo, L. (2014) · VCU Scholars Compass (Virginia Commonwealth University)
Metadata
- Authors
- Joos, A. A. B., Saum, B., van Elst, L. T., Perlov, E., Glauche, V., Hartmann, A., Freyer, T., Tüscher, O., & Zeeck, A.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Joos, Andreas A.B.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 191
- Issue
- 3
- Pages
- 189-195
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2126841876
- Cited by
- 124
- References
- 57
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 12 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 3 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 12
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Albert-Ludwigs-Universität Freiburg
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- anorexia nervosa, restrictive anorexia nervosa, right amygdala, midcingulate cortex, emotional processing, disgust, eating disorders, brain activity
- MeSH terms
- Adult, Amygdala, Anorexia Nervosa, Brain Mapping, Cerebral Cortex, Emotions, Female, Food, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Oxygen, Photic Stimulation, Young Adult
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