Cited by 112Suicide and Self-Harm StudiesNeural and Behavioral Psychology StudiesPsychopathy, Forensic Psychiatry, Sexual Offending

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Structural and functional alterations of the suicidal brain: An updated review of neuroimaging studies

Bani-Fatemi, Ali, Tasmim, Samia, Graff-Guerrero, Ariel, Gerretsen, Philip, Strauss, John, Kolla, Nathan, Spalletta, Gianfranco, De Luca, Vincenzo·2018·Psychiatry Research Neuroimaging

DOI 10.1016/j.pscychresns.2018.05.008

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Abstract

Brain imaging is a non-invasive and in vivo direct estimation of detailed brain structure, regional brain functioning and estimation of molecular processes in the brain. The main objective of this review was to analyze functional and structural neuroimaging studies of individuals at risk for suicide. We reviewed articles published between 2005 and 2018, indexed in PubMed and Medline, assessing structural and functional alterations of the brain of individuals at high risk for suicide and at low risk for suicide. We reviewed functional and structural neuroimaging studies which included individuals with a history of suicidal ideation or attempt in major depressive disorder (MDD), bipolar disorder (BD), psychosis, and borderline personality disorder (BPD). We selected 45 papers that focused on suicidality in MDD, 17 papers on BD, 11 papers on psychosis, and 5 papers on BPD. The suicidal brain across psychiatric diagnoses seems to heavily involve dysfunction of the fronto-temporal network, primarily involving reductions of gray and white matter volumes in the pre-frontal cortex (PFC), anterior cingulate, and superior temporal gyrus. Nonetheless, there are several ways to define suicidal behaviour and ideation. Therefore, it still remains difficult to combine the evidence from imaging studies that used different definitions of suicidality.

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Infusing Hope Into the Treatment of Suicidality: a Review of Ketamine’s Effects on Suicidality
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Authors: Bani-Fatemi, A., Tasmim, S., Graff-Guerrero, A., Gerretsen, P., Strauss, J., Kolla, N., Spalletta, G., & De Luca, V.
Affiliations: Centre for Addiction and Mental Health (CA)
University of Toronto (CA)
Baylor College of Medicine (US)
ORCID: Gerretsen, Philip
Kolla, Nathan
Spalletta, Gianfranco
Venue: Psychiatry Research Neuroimaging
Publisher: Elsevier BV
Published: 2018-08
Volume: 278
Pages: 77-91
ISSN: 0925-4927 (ISSN-L)
DOI: 10.1016/j.pscychresns.2018.05.008
OpenAlex: W2803650243
Cited by: 112
References: 87
Citations by year: 2026: 13 · 2025: 14 · 2024: 7 · 2023: 22 · 2022: 15 · 2021: 15 · 2020: 15 · 2019: 10 · 2018: 1
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research Neuroimaging (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: suicide, suicidal ideation, suicide attempts, brain structure, brain function, major depressive disorder, bipolar disorder, psychosis, borderline personality disorder, fronto-temporal network, prefrontal cortex, anterior cingulate cortex, superior temporal gyrus, gray matter volume, white matter volume
MeSH terms: Bipolar Disorder, Borderline Personality Disorder, Brain, Major Depressive Disorder, Humans, Magnetic Resonance Imaging, Suicidal Ideation, Neuroimaging, White Matter

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Structural and functional alterations of the suicidal brain: An updated review of neuroimaging studies

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