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Structural and functional alterations of the suicidal brain: An updated review of neuroimaging studies
Abstract
Brain imaging is a non-invasive and in vivo direct estimation of detailed brain structure, regional brain functioning and estimation of molecular processes in the brain. The main objective of this review was to analyze functional and structural neuroimaging studies of individuals at risk for suicide. We reviewed articles published between 2005 and 2018, indexed in PubMed and Medline, assessing structural and functional alterations of the brain of individuals at high risk for suicide and at low risk for suicide. We reviewed functional and structural neuroimaging studies which included individuals with a history of suicidal ideation or attempt in major depressive disorder (MDD), bipolar disorder (BD), psychosis, and borderline personality disorder (BPD). We selected 45 papers that focused on suicidality in MDD, 17 papers on BD, 11 papers on psychosis, and 5 papers on BPD. The suicidal brain across psychiatric diagnoses seems to heavily involve dysfunction of the fronto-temporal network, primarily involving reductions of gray and white matter volumes in the pre-frontal cortex (PFC), anterior cingulate, and superior temporal gyrus. Nonetheless, there are several ways to define suicidal behaviour and ideation. Therefore, it still remains difficult to combine the evidence from imaging studies that used different definitions of suicidality.
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“Several prior reviews have highlighted brain regions implicated in suicidal (32, 45–49) and non-suicidal behaviors (39, 50).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [46]
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Schmaal, L., Pozzi, E., Ho, T. C., van Velzen, L. S., Veer, I. M., Opel, N., Someren, E. J. W. V., Han, L. K. M., Aftanas, L., Aleman, A., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0842-6 · Cited by 261
Neural correlates associated with suicide and nonsuicidal self-injury in youth
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Neuroimaging the consciousness of self: Review, and conceptual-methodological framework
Frewen, P., Schroeter, M. L., Riva, G., Cipresso, P., Fairfield, B., Padulo, C., Kemp, A. H., Palaniyappan, L. K., Owolabi, M. O., Kusi‐Mensah, K., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.023 · Cited by 186
“Moreover, the authors found altered RSFC in the PCC, PRC, MPFC, and temporoparietal areas to be associated with suicide risk, all ROIs considered herein to primarily underlie V-SRP (Bani-Fatemi et al., 2018).”
Metadata
- Authors
- Bani-Fatemi, A., Tasmim, S., Graff-Guerrero, A., Gerretsen, P., Strauss, J., Kolla, N., Spalletta, G., & De Luca, V.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Baylor College of Medicine (US)
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 278
- Pages
- 77-91
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2803650243
- Cited by
- 112
- References
- 87
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 7 · 2023: 22 · 2022: 15 · 2021: 15 · 2020: 15 · 2019: 10 · 2018: 1
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- suicide, suicidal ideation, suicide attempts, brain structure, brain function, major depressive disorder, bipolar disorder, psychosis, borderline personality disorder, fronto-temporal network, prefrontal cortex, anterior cingulate cortex, superior temporal gyrus, gray matter volume, white matter volume
- MeSH terms
- Bipolar Disorder, Borderline Personality Disorder, Brain, Major Depressive Disorder, Humans, Magnetic Resonance Imaging, Suicidal Ideation, Neuroimaging, White Matter
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