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Cited by 92Treatment of Major DepressionSuicide and Self-Harm StudiesTryptophan and brain disorders

No Evidence for an Association between Serum Cholesterol and the Course of Depression and Suicidality

Deisenhammer, Eberhard A., Kramer-Reinstadler, Karin, Liensberger, Dietmar, Kemmler, Georg, Hinterhuber, Hartmann, Wolfgang Fleischhacker, W.·2004·Psychiatry Research
DOI 10.1016/j.psychres.2003.09.007
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Abstract

In a number of previous reports, an association of altered, in most cases lower, serum cholesterol levels with depression, suicidal ideation and current or past suicidal behavior has been suggested. In this investigation, the course of serum cholesterol concentrations was measured in depressed patients during treatment. Ninety-two inpatients with a major depressive episode were included. Serum lipid concentrations were assessed at admission, after 1 week and after 4 weeks of antidepressant treatment. Degrees of depression and suicidality were measured with the Hamilton Depression Rating Scale. Although there was a significant reduction in depression and suicidality scores, neither a significant change in serum cholesterol levels nor a correlation between cholesterol levels and clinical improvement was found. Further, there were no significant differences in lipid levels between patients with and without a history of attempted suicide. In patients who had used a violent method, there was a trend for lower total cholesterol levels compared to those who had poisoned themselves. The results of this study do not support the hypothesis of an association of serum cholesterol with the course of depression and suicidal ideation. Cholesterol levels do not appear to be an appropriate biological marker for suicidality during the first 4 weeks of treatment in patients with a major depressive episode.

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Authors
Deisenhammer, E. A., Kramer-Reinstadler, K., Liensberger, D., Kemmler, G., Hinterhuber, H., & Wolfgang Fleischhacker, W.
Affiliations
Innsbruck Medical University (AT)
Corresponding author
Deisenhammer, Eberhard A.
ORCID
Deisenhammer, Eberhard A.
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2004-01
Volume
121
Issue
3
Pages
253-261
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2003.09.007
OpenAlex
W2073440692
Cited by
92
References
65
Citations by year
2025: 5 · 2024: 3 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 7 · 2013: 3 · 2012: 5
FWCI
2.36
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
serum cholesterol, depression, suicidality, suicidal ideation, major depressive episode, antidepressant treatment, serum lipids, suicide attempts, biomarkers, treatment response
MeSH terms
Adult, Cholesterol, Major Depressive Disorder, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Personality Inventory, Psychometrics, Statistics as Topic, Suicide, Attempted, Triglycerides, Risk Assessment

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