Changes in Plasma Cholesterol in Mood Disorder Patients: Does Treatment Make a Difference?
Abstract
Objectives To examine the impact of treatment in patients with acute episodes of major depressive (MD) and manic or hypomanic (M/HM) episodes and co-morbid generalized anxiety symptoms, on the total cholesterol blood levels (TC).Method A consenting series of patients with acute episodes of DSM IV-R confirmed diagnosis of MD or M/H were included. Subjects were treated with antidepressants, mood stabilizers, or both. The Hamilton depression scale (HAM-D21), the modified mania rating scale (MMRS), and the Hamilton anxiety scale (HAM-A) were utilized to evaluate clinical symptoms. Blood samples were drawn for TC estimations after 10 h of fasting on two occasions over time. The first sample was taken before treatment was started, and the second 4 weeks after treatment. The relationship between changes in TC and the severity of psychiatric symptoms, as measured on HAM-D, MMRS, and the HAM-A, were analysed.Results 56 subjects (34 with MD and 22 with M/HM episodes) completed the study. About 4 weeks after treatment there was a statistically significant increase in the TC in patients with MD versus a significant decrease in patients with M/HM episodes.Conclusion Our results replicate earlier reports of significant increase in the cholesterol levels in depressed patients after treatment. We report a significant decrease of TC levels in M/HM episodes with treatment. Although the results in previous reports and in our study are statistically significant, their clinical significance requires further examination in longer-term studies.
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Antidepressants cause changes in blood lipid composition.
“Along with antipsychotic drugs, antidepressants also cause changes in blood lipid composition.”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [142]
Many studies have shown a negative effect of antidepressants on lipid metabolism.
“Many studies have shown the negative effect of antidepressants on lipid metabolism [142,143].”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [142]
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- Authors
- Gabriel, A.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Gabriel, A.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 99
- Issue
- 1-3
- Pages
- 273-278
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2129605044
- Cited by
- 26
- References
- 36
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 2 · 2014: 1
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- serum cholesterol, total cholesterol, major depressive disorder, manic episodes, hypomanic episodes, mood disorders, antidepressant treatment, mood stabilizers, generalized anxiety disorder, treatment response
- MeSH terms
- Acute Disease, Adult, Anticonvulsants, Anxiety Disorders, Bipolar Disorder, Cholesterol, Major Depressive Disorder, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Comorbidity, Body Mass Index, Selective Serotonin Reuptake Inhibitors, Antidepressive Agents, Second-Generation, Antimanic Agents, Risperidone
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